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Evotec Achieves Key Milestones in Its Collaboration with Bristol Myers Squibb On Targeted Protein Degradation

The Pharma Data

Evotec and Bristol Myers Squibb (the successor in interest to Celgene ) initiated their long-term strategic drug discovery and development partnership in the field of targeted protein degradation in 2018 with the goal to identify novel drug targets.

Protein 40
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News from AACR 2024: Sunday’s highlights

Drug Discovery World

Aviv Regev, Head and Executive Vice President of Research and Early Development at Genentech, opened the session with a discussion of how advances in genomic sequencing are fostering the development of data-rich cell atlases and what that data could mean for new insights into cancer biology and novel therapeutics.

In-Vivo 52
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Meet the industry: Who’s at Drug Discovery 2023?

Drug Discovery World

When it comes to the technologies driving drug discovery, she thinks that the ability to specifically edit regions of the genome using CRISPR/Cas9 is particularly revolutionary. For example, to identify protein structures and even binding pockets from sequence data and modelling potential hits in silico.

Drugs 59
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Boehringer to investigate ‘dark antigens’ with UK cancer specialist Enara

pharmaphorum

Dark Antigens represent a new class of cancer-associated antigens that derive from the genomic “dark matter” – the portion of the human genome that is normally not expressed as protein. These sequences are usually silenced in healthy cells but are activated and presented on tumour cells.

Genome 58
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IN FOCUS: Solvias

Pharmaceutical Technology

In regards to the latter, notable examples include the acquisition of Cergentis, a genomics-focused biotechnology company based in the Netherlands. The deal allows the company to provide proprietary technology and knowledge steeped in fast-evolving genomic techniques that support effective decision-making and R&D program design.

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Enara Bio, Boehringer Ingelheim Agree to Collab on Immunotherapy Discovery Research

The Pharma Data

Dark Antigens are in reference to a newer class of cancer antigens derived from a portion of the human genome not normally expressed as a protein. This portion of the genome is dubbed the “genomic dark matter.” Additional royalties on future product sales will also be directed toward Enara. “We

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GSK ends 2020 with multi-million dollar deal frenzy to boost R&D

pharmaphorum

million on the table if certain development, regulatory and sales goals are achieved. Surface could receive up to $730 million in future milestone payments as well as tiered royalties on global net sales. The antibody targets PVRIG, an inhibitory protein expressed on natural killer cells (NK cells) and T-cells.