Drug Discovery World

JULY 3, 2023

The OXEGENE dataset contains anonymised genotype data including disease stage and infertility status, from 1,000 surgically confirmed patients. We hope that the analysis of our data will lead to the development of precision medicines to improve the lives of patients.”

Genetics 52

Genetics Genotype Medicine Licensing 52

Scienmag

JANUARY 13, 2021

To discover these associations, researchers need to compare the genomes of many individuals at millions of genetic locations or markers, and therefore require cost-effective genotyping technologies. A new statistical method, developed […].

Genome 57

Genome Genomics Genotype Genetics 57

Scienmag

MAY 16, 2021

The fully human monoclonal antibody produced sustained reductions in triglyceride levels of up to 82 percent, depending on the patient’s genotype, while also lowering the […].

Antibody 45

Antibody Genotype Drugs Clinical Trials 45

Delveinsight

DECEMBER 13, 2020

This discovery led to the development of diagnostic tests and an effective vaccine, and Blumberg was awarded the Nobel Prize in Physiology or Medicine in 1976 for this discovery. Hepatitis C treatment options, without a doubt, have improved significantly, including pan-genotypic medications that are used to treat all genotypes and subtypes.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Drug Discovery World

NOVEMBER 23, 2023

In anticipation of the long-awaited personalised medicine revolution, many different types of biobanks have emerged to catalogue samples. Towards personalised medicine for populations From my vantage point, we are still in the early days of understanding the value of biobanked samples and AI-models in designing new drugs.

Biobanking 59

Biobanking Drugs Medicine Genome 59

pharmaphorum

JANUARY 29, 2023

The EMA’s human medicines committee has started a review of Novartis’ sickle cell disease (SCD) therapy Adakveo, shortly after the company reported that it failed to show efficacy in a phase 3 trial. That study showed that Adakveo lowered the median annual rate of VOCs to 1.63 compared to 2.98

Genotype 52

Genotype Trials Antibody Regulation 52

Drug Discovery World

FEBRUARY 27, 2024

From these data, we can discover new medicines with a higher probability for success. In oncology and other areas of medicine, significant progress has been made by advances in genomics to better define patient biology to enable targeted precision therapeutics. Is AI / machine learning (ML) the best way to utilise this data at scale?

Genome 52

Genome Genomics Genotype Medicine 52

The Pharma Data

OCTOBER 9, 2021

Food and Drug Administration (FDA) Antimicrobial Drugs Advisory Committee (AMDAC) voted unanimously to recommend use of maribavir (TAK-620) for the treatment of refractory cytomegalovirus (CMV) infection and disease with genotypic resistance to ganciclovir, valganciclovir, foscarnet or cidofovir in transplant recipients.

Drugs 52

Drugs Genotype Bioavailability Medicine 52

pharmaphorum

NOVEMBER 10, 2021

That’s according to a newly published report from the US National Academies of Sciences, Engineering, and Medicine, which calls for a One Health approach that recognises the scale of the challenge, and the interconnectivity of its potential solutions. Growing threat of AMR. million human infections and 35,900 deaths every year in the US.

Medicine 105

Medicine Genome Genomics Genotype 105

pharmaphorum

JANUARY 24, 2023

The decision makes sense for all parties – the pharma companies receive analysis that could help them develop their next medicine, while the researchers behind the project have the funding and additional expertise to pursue their aims. Certain genetic variants influence the way the body responds to specific medicine.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

The Pharma Data

SEPTEMBER 8, 2021

As manufacturer of custom oligonucleotides the company partnered in the development of molecular diagnostics and built a broad portfolio of diagnostic assays, in particular for inherited genetic as well as somatic mutation testing, quantitative assays for haematology and transplantation medicine.

Genotype 52

Genotype Reagent Genetics Research 52

XTalks

SEPTEMBER 28, 2020

The liquid biopsy will therefore help personalize medicines for patients based on the molecular features of their disease. Liquid biopsies are an exciting way forward in the future of cancer diagnostics, cancer therapy and personalized medicine.

Gene 105

Gene DNA Life Science Genotype 105

Roots Analysis

APRIL 28, 2024

Absence of Biomarkers for Diagnosis: Due to the absence of genotype-phenotype correlations and prognostic markers, there have been challenges in the diagnosis and treatment of rare kidney diseases. Insufficient Model Organisms: Limitations of these model organisms includelong generation time and strain effects.

Genetics 40

Genetics Genotype Development FDA Approval 40

XTalks

JANUARY 22, 2021

It identifies bacteria using both genotypic and phenotypic assessments within 1.5 The test is geared towards precision medicine for antibiotics in order to target the emergence of antimicrobial resistance. “We The tool can select different combinations of multiple antibiotics deemed suitable for treating specific bacterial infections.

Bacteria 52

Bacteria In-Vitro Genotype Marketing 52

pharmaphorum

AUGUST 11, 2022

The best way to do that is to target specific sub-populations, which will serve as a natural lead into personalised medicine becoming more mainstream. The program is aiming to genotype roughly 150,000 participants over the next few years to demonstrate the impact personalised testing can have on a large scale.

Genome 98

Genome Genomics Genetics Drugs 98

The Pharma Data

MARCH 16, 2022

As a manufacturer of custom oligonucleotides the company partnered in the development of molecular diagnostics and built a broad portfolio of diagnostic assays, in particular for inherited genetic as well as somatic mutation testing, quantitative assays for haematology and transplantation medicine.

In-Vitro 52

In-Vitro Genotype Reagent Protein 52

The Pharma Data

NOVEMBER 18, 2020

An increased use of HIV medicines has been accompanied by the emergence of HIV drug resistance, which has also steadily increased in recent years. . The recommended specimen types for HIV drug resistance genotyping are plasma or dried blood spots. As of December 2019, 25.4 were receiving ART globally. Source link.

Drugs 52

Drugs Genotype Medicine Development 52

The Pharma Data

MARCH 7, 2022

The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. director of the FDA’s Center for Veterinary Medicine. “It This is the FDA’s first low-risk determination for enforcement discretion for an IGA in an animal for food use.

Genome 52

Genome Genomics Production Marketing 52

The Pharma Data

DECEMBER 9, 2020

5 and attracted participants from around the world, including radiologists, radiation oncologists, physicists in medicine, radiologic technologists, and other health care professionals. The annual meeting of the Radiological Society of North America was held virtually this year from Nov. 29 to Dec. ” Press Release. WEDNESDAY, Dec.

Radiology 52

Radiology Biobanking Genotype Medicine 52

The Pharma Data

NOVEMBER 10, 2020

Biomarkers will be critical to developing precision medicine for Alzheimer’s disease. professor of neuropathology, School of Medicine, University of Tokyo, underscored, “Alzheimer’s disease is a relentless, fatal disease, creating a health crisis for patients, families, and nations. Michael Vi/Shutterstock. As Takeshi Iwatsubo, M.D.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Antibody 52

XTalks

MARCH 3, 2021

Joffe, MD, director of the Office of Rare Diseases, Pediatrics, Urologic and Reproductive Medicine in the FDA’s Center for Drug Evaluation and Research, in a press announcement from the FDA. “Today’s action marks the first FDA approval for a therapy to treat this devastating disease,” said Hylton V.

FDA Approval 64

FDA Approval Genotype Clinical Trials Clinical Trials 64

XTalks

NOVEMBER 10, 2020

HS: Well, a definitive diagnosis opens the door to personalized medicine, potentially leading to reduced morbidity and mortality. It also slows the progress of identifying new disease gene associations in very rare conditions. What are the benefits of having a definitive diagnosis for patients with genetic disorders?

Genome 98

Genome Genomics Medicine Genetic Disease 98

Delveinsight

AUGUST 25, 2021

The pharmaceutical industry finds, develops, manufactures, and promotes medicines or pharmaceutical drugs for usage as medications that are administered (or self-administered) to patients in order to cure, vaccinate, or relieve symptoms. Pharmaceutical companies play a vital part in our lives and in helping us to live healthier lives.

Vaccination 98

Vaccination Vaccine Sales Drugs 98

The Pharma Data

DECEMBER 9, 2020

Vigil’s pipeline strategy is to target these diseases by combining a high-level understanding of microglia physiology, disease genotyping, and patient phenotyping to identify specific genetic variations associated with microglial dysfunction. Li is a prominent neuroscientist and former professor at Johns Hopkins Medicine.

Marketing 52

Marketing In-Vivo Protein In-Vitro 52

XTalks

APRIL 24, 2023

According to Dr. Melanie Blank, clinical team leader for General Medicine Branch 1 at the US Food and Drug Administration’s (FDA) Division of Clinical Evaluation and Pharmacology/Toxicology (DCEPT), the agency is seeing one or two new applications coming in every week for new gene therapies for different diseases.

Gene Therapy 95

Gene Therapy Gene Trials Clinical Trials 95

The Pharma Data

MARCH 25, 2021

Canada, Switzerland and Australia, as well as in Singapore through our partner Everest Medicines. Medicines targeting these receptors therefore are not typically effective in treating TNBC. Gilead Sciences, Inc. In addition to the European Union, regulatory reviews of SG in metastatic TNBC are currently underway in the U.K.,

Genotoxicity 52

Genotoxicity Genotype Containment Protein 52

The Pharma Data

DECEMBER 9, 2020

The new company, created by Hillhouse Capital Venture Partners, launched this week with a mission to pursue the most promising advances in medicine for underserved patients in Asia and around the world. A solution could be at hand with Overland Pharmaceuticals. osteolabs – Germany’s osteolabs GmbH raised €1.6

In-Vivo 52

In-Vivo In-Vitro Antibody Development 52

Drug Discovery World

OCTOBER 30, 2023

RA: You’ve recently announced a collaboration with the University of Oxford to access genotype data on women with endometriosis. We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients.

Genome 72

Genome Genomics Genotype Clinical Trials 72

pharmaphorum

DECEMBER 9, 2020

The European Medicines Agency (EMA) has granted a conditional marketing authorisation for the drug that will be marketed as Zinteglo (betibeglogene autotemcel), meaning its licence must be renewed each year until confirmatory data is available. In Europe bluebird has set a price of up to $1.58 million euros for a single shot.

Gene Therapy 59

Gene Therapy Gene Genotype Marketing 59

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. This includes precision medicine strategies which can be effectively guided through high-level translational research led by clinical data.

Research 98

Research Biobanking Drugs Genome 98

Drug Discovery World

DECEMBER 12, 2023

Context and treatment potential AATD is an inherited, autosomal recessive genetic disorder that is most frequently caused by a single nucleotide variant (SNV) mutation in the SERPINA1 gene, the most common of which is the ‘PiZ’ mutation.

RNA 52

RNA In-Vivo Genotype Genetics 52

Drug Discovery World

APRIL 4, 2024

To date, the samples for the Biobank have been genotyped using microarray-based methods. However, data generated via this method are lower resolution, had limited scope for detecting complex or unknown variants, and rely on reference genomes, meaning results may be biased towards participants from well-represented demographics.

Biobanking 52

Biobanking Genome Genomics Genome Project 52

The Pharma Data

SEPTEMBER 2, 2021

AstraZeneca will present new data across its diverse portfolio of cancer medicines at the International Association for the Study of Lung Cancer (IASLC) 2021 World Conference on Lung Cancer (WCLC) and the European Society for Medical Oncology (ESMO) Congress 2021. Lead author. Abstract title. Presentation details. Immuno-Oncology.

Trials 52

Trials Medicine Antibody Clinical Trials 52

The Pharma Data

APRIL 7, 2021

“Women with triple-negative breast cancer have historically had very few effective treatment options and faced a poor prognosis,” said Aditya Bardia, MD, MPH, Director of Breast Cancer Research Program, Mass General Cancer Center and Assistant Professor of Medicine at Harvard Medical School, and global principal investigator of the ASCENT study.

HR 52

HR Genotype FDA Approval Genotoxicity 52

Roots Analysis

SEPTEMBER 20, 2023

Cannabis as a Medicinal Plant: Key Component of Safety Assessment Medical cannabis is a rising star in the healthcare domain. Cannabis testing is also done to identify the plant genotype used to develop the product, providing transparency to the consumers.

Laboratory Information Management System 40

Laboratory Information Management System Production Contamination Containment 40

The Pharma Data

APRIL 14, 2021

Tagawa, MD, MS, FACP, Professor of Medicine and Urology at Weill Cornell Medicine, an oncologist at New York-Presbyterian/Weill Cornell Medical Center and principal investigator of the TROPHY study. Canada, Switzerland and Australia, as well as in Singapore through our partner Everest Medicines.

Genotype 52

Genotype Containment FDA Approval Genotoxicity 52

Drug Discovery World

JULY 15, 2022

This technical tour de force will have far reaching implications for our understanding of the human genome and for practical use of this knowledge in clinical medicine. Future challenges for translating genomics into genomic medicine. However, the work was not done and about 8% of the genome remained in the dark until recently.

Genome 52

Genome Genomics DNA Containment 52