Pharmaceutical Technology

SEPTEMBER 14, 2022

API peptides and proteins-based drugs have gained much attention in the past decade. Discover the top API protein and peptide companies in contract marketing. Technologies in the delivery of peptides and proteins. They are promising therapeutics for the treatment of a variety of metabolic and oncological disorders.

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Protein Marketing Manufacturing Reagent 130

Pharmaceutical Technology

DECEMBER 7, 2022

BioPIPS plans to utilise research and innovation to enhance the biologics manufacturing expertise of Singapore, which comprises recombinant therapeutic proteins and vaccines. The post GSK, Sanofi, Takeda and scientists in Singapore partner for biologics appeared first on Pharmaceutical Technology.

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Scientist Manufacturing Vaccination Vaccine 130

Scienmag

DECEMBER 23, 2021

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

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Protein Scientist Research Medicine 92

Scienmag

SEPTEMBER 22, 2021

CHAPEL HILL, NC – Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways. One of them, called MUC5B, is crucial for the innate defense against the various things we inhale.

Protein 77

Protein Scientist Medicine 77

Pharmaceutical Technology

JULY 7, 2022

But scientists have struggled to find effective treatments for many of these diseases since the dawn of modern medicine. Often referred to as a type of gene-modified cell therapy, CAR-T cell therapies involve genetically modifying a patient’s own T cells to produce a protein that enables them to identify and kill cancer cells.

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Gene Therapy Gene Medicine Genetics 245

Scienmag

JULY 4, 2022

Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) […].

Scientist 71

Scientist Protein Drugs Medicine 71

Medical Xpress

NOVEMBER 10, 2022

Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The research, led by scientists from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, U.K.,

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Protein Scientist Medicine Research 75

Scienmag

MARCH 1, 2022

March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […]. AUGUSTA, Ga.

Protein 77

Protein Scientist Medicine 77

Drug Discovery World

MAY 18, 2023

Scientists in Japan have used a novel technique to identify a protein complex degraded by autophagy that has a possible role in liver cancer. p62 protein forms a membrane-less cytosolic organelle called p62 body and helps in the selective removal of toxic cellular waste through autophagy.

Protein 52

Protein Scientist Medicine Regulation 52

Scienmag

JULY 6, 2022

Now, a team of scientists from the Salk Institute and Rutgers University have for the first time determined the molecular structure of HIV Pol, a protein that plays […].

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Protein Scientist Development Medicine 88

Scienmag

JULY 20, 2021

New research published in the Journal of Leukocyte Biology reveals that certain protein markers may indicate which patients have stable forms of CLL and which have more aggressive types. Identifying these proteins may not only help determine patients’ prognoses but also point […].

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Protein Scientist Research Medicine 75

Scienmag

JUNE 16, 2022

Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.

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Scientist Gene Development Protein 77

Scienmag

MARCH 29, 2021

Findings from Johns Hopkins Medicine study have potential implications for understanding cancer cell spread Credit: Deborah Andrew and JiHoon Kim, Johns Hopkins Medicine. Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions.

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Scientist Medicine Protein 98

Scienmag

OCTOBER 12, 2020

Potential new antibiotics work by disrupting bacterial membrane and summoning immune cells in animal models PHILADELPHIA–A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

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Bacteria Engineer Scientist Medicine 40

Scienmag

APRIL 30, 2021

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease Credit: Salk Institute LA JOLLA–(April 30, 2021) Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells.

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Protein Scientist Research Medicine 97

Medical Xpress

JANUARY 31, 2023

Now, scientists based at the University of California Los Angeles have found that compounds which target the circadian clock and affect the synthesis of collagen—a protein which is important for skin repair—could improve scar healing. It may even require further surgical treatment.

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Medicine Protein Scientist Research 98

Scienmag

APRIL 27, 2021

Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke. Scientists from the departments of […].

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Protein Research Scientist Medicine 96

Scienmag

NOVEMBER 11, 2020

Yale researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection, they report Nov. 11 in the journal PLOS Pathogens.

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Protein Scientist Research Medicine 63

Scienmag

MARCH 29, 2021

– New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the […].

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Protein Scientist Research Allergies 88

Scienmag

MAY 11, 2021

The researchers have demonstrated that silencing or inhibiting the activity of these proteins completely reverses the aortic disease in a mouse model of Marfan Syndrome Credit: CNIC Scientists at the Centro Nacional de Investigaciones Cardiovasculares Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) (..)

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Protein Scientist Research Cardiology 96

Scienmag

JULY 22, 2021

New UCLA research identifies TAF12 as a potential cancer drug target FINDINGS Scientists from the UCLA Jonsson Comprehensive Cancer Center have identified a key protein, transcription factor TAF12, that plays a critical role in the formation of a preinitiation complex, which consists of over one hundred proteins that are necessary for the transcription (..)

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Scientist Protein Drugs Research 75

Scienmag

MAY 27, 2021

A digital tool that will make it cheaper, safer and faster to develop new medicines is being rolled out by scientists from the University of Bath in the UK.

Protein 52

Protein Scientist Medicine Development 52

Scienmag

APRIL 27, 2022

CHAPEL HILL, NC – Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Those specific “regulatory” proteins are called transcription factors, and they do their thing by binding to […].

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Scientist Gene RNA Protein 83

Scienmag

MARCH 12, 2021

Findings provide clues to how toxic proteins clump and spread CLEVELAND–Scientists at the Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders–findings that provide clues to how toxic proteins clump and (..)

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Protein Scientist Medicine 44

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

Protein 52

Protein Gene Genome Genomics 52

Drug Discovery World

MARCH 21, 2023

The work promises to reduce the threats of viral contamination when harnessing bacteria to produce medicines such as insulin as well as other useful substances, such as biofuels. coli to make all their life-sustaining proteins from 61 sets of genetic building blocks, or codons, instead of the naturally occurring 64.

Engineer 52

Engineer Genetic Engineering Scientist Bacteria 52

Scienmag

MARCH 18, 2021

— Scientists at the University of Wisconsin-Madison have developed a way to use a cell’s own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. Some cancers, for instance, are associated with abnormal proteins or an excess of normally harmless proteins.

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Protein Scientist Development Drugs 49

Pharma Times

DECEMBER 18, 2023

MCI patients had 25% lower levels of serotonin compared to healthy patients Researchers from Johns Hopkins Medicine have suggested that serotonin loss in parts of the brain may play a role in cognitive decline in the early stages of Alzheimer’s disease (AD). MCI describes the diagnostic stage between normal brain function in ageing and AD.

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Medicine Scientist Protein Research 107

Scienmag

NOVEMBER 17, 2020

Scientists have established a new method to image proteins that could lead to new discoveries in disease through biological tissue and cell analysis and the development of new biomaterials that can be used for the next generation of drug delivery systems and medical devices.

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Protein Drug Delivery Systems Drug Delivery Scientist 67

Scienmag

DECEMBER 24, 2020

Credit: Tohoku University Tohoku University scientists have, for the first time, provided experimental evidence that cell stickiness helps them stay sorted within correct compartments during development. How tightly cells clump together, known as cell adhesion, appears to be enabled by a protein better known for its role in the immune system.

Protein 52

Protein Development Scientist Medicine 52

Scienmag

APRIL 22, 2021

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Researchers have identified another potential target for neutralizing antibodies on the SARS-CoV-2 Spike protein that is masked by metabolites in the blood.

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Antibody Protein Scientist Research 46

Scienmag

JUNE 29, 2022

In ACS Infectious Diseases, scientists now report that apratoxin S4, an anticancer drug candidate that targets a […]. More than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2.

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Protein Scientist Drugs Research 87

Scienmag

JANUARY 11, 2021

Fralin Biomedical Research Institute at VTC scientists say brain protein deficit boosts susceptibility to seizures Credit: Virginia Tech For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals.

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Protein Scientist Research Medicine 58

Scienmag

FEBRUARY 3, 2021

Scientists illuminate the protein’s role in rare genetic diseases often diagnosed during infancy or childhood Scientists at Scripps Research have clarified the workings of a mysterious protein called G?o, o, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.

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Protein Genetic Disease Genetics Scientist 42

Scienmag

AUGUST 11, 2020

An international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain.

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Scientist Gene Protein Research 62

The Pharma Data

SEPTEMBER 30, 2021

Scientists from the German Cancer research facility (DKFZ) and therefore the Medical Faculty Mannheim, Heidelberg University, have now identified a replacement protein produced by blood vessels that permits tumor cells to metastatically colonize organs. Science Translational Medicine, 2021. doi: 10.1126/scitranslmed.abe6805.

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Protein Scientist Antibody Research 52

Scienmag

JUNE 25, 2021

research published in Neuron shows how the loss of the protein hepaCAM drives brain development dysfunction and plays an important role in neurological disorders Credit: Baldwin Lab, UNC School of Medicine CHAPEL HILL, NC – When we think of the brain, we think of neurons. Led by Katie Baldwin, Ph.D.,

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Development Scientist Protein Medicine 55