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Epigenetics discovery could lead to new class of cancer drugs

Drug Discovery World

The study shows that H3K4me3 ensures genes are transcribed and activated at the right time in a controlled manner, like a set of traffic lights regulating the flow of cars on a busy road. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

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Grand Rounds November 18, 2022: The FIRST-ABC Pragmatic Trials of Non-Invasive Respiratory Support In Children (Padmanabhan Ramnarayan, MBBS, MD, FRCPCH, FFICM)

Rethinking Clinical Trials

Sick children, when they are acutely ill, start with standard oxygen therapy, which escalates to noninvasive respiratory support (CPAP/BIPAP or high flow nasal cannula) before invasive ventilation support in the ICU. Many other trials in the country were behind and everyone else had to stop. pctGR, @Collaboratory1.

Trials 130
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Perfusion MRI and Other Perfusion Imaging Techniques for Clinical Trials

XTalks

Perfusion imaging techniques evaluate the rate of flow and the permeability (the ability of contrast material to move from intravascular to extravascular space) that occur in the microvasculature within different tissues. An overview of the ASL MR perfusion technique to obtain cerebral blood flow (CBF) values. Figure from Ricart et al.,

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Orphan drugs and where to launch them: The keys to Europe’s forgotten territories

Pharmaceutical Technology

Due to the high price tags associated with these speciality medicines, innovators have naturally favoured big markets with high GDP such as the US and EU-5 (Germany, France, Spain, Italy, and the UK). “The Go-to-market strategies. The choice of where to launch an orphan drug is an important and difficult decision.

Drugs 147
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Further insight into breakthroughs in mRNA drug discovery 

Drug Discovery World

We have shown that the excipient does not only work for our SNAP-tag lipid (SNaP) LNP, but also for the commercialised vaccines. The excipient is listed in the pharmacopoeia as an inactive ingredient and therefore can easily added to an existing formulation.

Drugs 52
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Lyfgenia and Casgevy Become First FDA-Approved Gene Therapies for Sickle Cell Disease

XTalks

The sickled red blood cells obstruct flow in blood vessels, limiting oxygen delivery to tissues in the body, which leads to severe pain and organ damage called vaso-occlusive events (VOEs) or vaso-occlusive crises (VOCs). The mutation causes red blood cells to develop a crescent or “sickle” shape.

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Sponsored content: Why choose Bethyl antibodies for your R&D

Drug Discovery World

Our catalog of over 6,500+ primary antibodies, 1,200+ secondary antibodies, and 50+ ELISA kits includes reagents for multiplex IF, flow cytometry, and more in fields including immunology, oncology, and neuroscience. Pillar 5: Protein OE/Epitope Tags. Pillar 4: Biological Characteristics.