Remove tag metabolism
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First gene therapy trial for Hunter syndrome opens in Manchester, UK

Drug Discovery World

The clinical trial will be led by Professor Rob Wynn, Consultant Paediatric Haematologist at Royal Manchester Children’s Hospital (RMCH), together with Professor Simon Jones, Consultant in Paediatric Inherited Metabolic Disease at Saint Mary’s Hospital, and Professor Bigger.

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Grand Rounds December 2, 2022: A Randomized Controlled Trial of Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned (G. Michael Felker, MD, MHS)

Rethinking Clinical Trials

Director, Cardiovascular and Metabolism Research, DCRI.                                           . Speakers. Michael Felker, MD, MHS. Professor of Medicine. Pragmatic Clinical Trials, Heart Failure, Diabetes. Key Points. Sites have a lot of trials that are competing. One pays more than another.

Trials 130
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Gene Silencing Porphyria Treatment, Givlaari, Finally Wins Over England’s NICE Amid Stellar Long-Term Data

XTalks

After initial rejection from the National Institute for Health and Care Excellence (NICE) last year, the non-departmental public body of the Department of Health in England has now given the green light to the gene silencing treatment Givlaari (givosiran) for the treatment of the rare metabolic disorder, acute intermittent porphyria (AIP).

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2021 Hansen Family Award goes to Professor Kai Johnsson

The Pharma Data

using SNAP-tag) involves labeling cell proteins with a fluorescent dye, thereby enabling researchers to observe how proteins interact in the living cell and where in the cell they are located. With Spirochrome, he commercialized fluorescent probes for cell biology, while with Covalys, he marketed SNAP-tag and other protein labeling methods.

Protein 52
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Perfusion MRI and Other Perfusion Imaging Techniques for Clinical Trials

XTalks

For ASL MR perfusion, water molecules in arterial blood from a feeder artery are magnetically tagged and tracked until they reach the region of interest. Then, the signal difference in the region of interest between the tagged images and control images can be computed to obtain cerebral blood flow (CBF) values ( Figure 3 ).

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Tirzepatide Obesity Drug Shown to Reduce Body Weight by 20 Percent in Eli Lilly Trial

XTalks

These bind to their respective receptors to increase glucose metabolism by increasing insulin secretion. Wegovy had a price tag of $1,297 a month when it was first launched. A year ago, Eli Lilly’s SURPASS-2 study found tirzepatide to be superior to semaglutide in reducing blood sugar and body weight.

Trials 98
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Conjugation and Labeling of Molecules: A Burgeoning Approach in Therapeutics Development and Molecular Imaging

Roots Analysis

These molecules can be conjugated with various modalities, such as haptens, enzymes, isotopes, fluorescent tags, carrier proteins, polymers, particle conjugates and photoreactive molecules. Bioconjugation is a subset of conjugation where one of the entity is a biomolecule, such as protein or an antibody.