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World’s largest catalogue of ocean DNA could boost drug discovery

Drug Discovery World

For example, enzymes sourced from bacteria living around hydrothermal vents have been used to support the polymerase chain reaction, the test used for Covid-19 detection. ” The ability to collect and analyse such a new wealth of ocean data comes from major developments in DNA sequencing technology and computational power. .

DNA 103
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New CRISPR-Based Tool Called PASTE Gene Editing Inserts Large DNA Sequences at Desired Sites

XTalks

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

Verge Genomics’ potential amyotrophic lateral sclerosis (ALS) treatment VRG50635 is one of the first drugs to enter clinical trials that was entirely discovered and developed using an AI-enabled platform 6. Automation is also being applied to genomics sample preparation, an area that requires particular robustness and scalability.

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Women in Science Who Have Paved the Way Forward in Genetics

XTalks

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two. Rosalind Franklin.

Genetics 119
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The future of genomic medicine: can it fulfil its promises?

pharmaphorum

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential.

Genome 106
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Winship Cancer Institute of Emory University Joins Caris’ Precision Oncology Alliance

The Pharma Data

By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through the Caris Molecular Intelligence® platform, physicians from Winship will be able to further prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients. Brille , Vice Chairman of Caris Life Sciences.

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The microbiome in precision medicine

Drug Discovery World

With 100-fold the number of genes in the human genome 1 , this microbial collection is a rich genetic signature of clinical significance that we have only recently gained the tools to explore. Genome editing tools such as CRISPR may be employed to create “live biotherapeutics” (drugs composed of living bacteria).