Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. The vaccine also contains other inactive ingredients such as cholesterol.

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Vaccination Vaccine Containment Immune Response 130

Drug Discovery World

NOVEMBER 17, 2022

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

Bacteria 52

Bacteria Engineer Gene Genetics 52

pharmaphorum

MAY 7, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of the gene editing technology and has refined it to the point where it can be used to accurately edit DNA to correct genetic conditions or modify cells to fight disease.

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Gene Editing Gene Genetic Engineering DNA 52

pharmaphorum

JANUARY 20, 2021

Ella, 28, was diagnosed with cystic fibrosis – a rare genetic disease which causes a build-up of thick, sticky mucus in the lungs, digestive tract, and sinuses – at 18 months old. This sticky mucus gets trapped and breeds infections from bacteria I inhale,” says Ella, who adds she was “terrified” of doctors as a child.

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Bacteria Bacterium DNA Doctors 92

The Pharma Data

JANUARY 4, 2021

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. The UC Santa Barbara research uses a method that addresses not only antibiotic overuse, but also the containment of genetically modified organisms (GMOs). “If

Bacteria 52

Bacteria Engineer Genetics Genetic Engineering 52

pharmaphorum

APRIL 23, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of gene editing technology and has refined its technology to the point where it can be used to accurately edit someone’s DNA to correct genetic conditions.

Gene Editing 62

Gene Editing Gene DNA Bacteria 62

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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Gene Editing DNA Gene Gene Sequencing 98

Roots Analysis

JANUARY 14, 2024

Different types of expression system for the production of biologics have been mentioned in the following sections: Insect Expression Systems: Baculovirus is a double stranded DNA (dsDNA) lytic virus that can be effectively amplified in insect cells belonging to the Lepidoptera family.

Contract Manufacturing 40

Contract Manufacturing Manufacturing Protein Bacteria 40

Roots Analysis

OCTOBER 16, 2023

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.

DNA 40

DNA Gene Protein In-Vitro 40

XTalks

FEBRUARY 11, 2021

This has ushered in a new era of genomics that is fostering rapid, detailed and personalized insights into human genetics. Xtalks is celebrating the International Day of Women and Girls in Science with a special overview of notable female scientists who have made revolutionary contributions to the field of genetics. Rosalind Franklin.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

FEBRUARY 6, 2024

million data points from ALS patient tissue and genetics datasets to discover loss of endolysosomal function as a new causative mechanism in ALS, and uncovered PIKfyve as a promising new therapeutic target. The company’s platform evaluated more than 11.4 Obulytix is not alone.

Marketing 69

Marketing Medicine Genome Genomics 69

The Pharma Data

OCTOBER 19, 2020

“Molecular profiling is a powerful tool that Winship’s physicians can utilize to optimize cancer treatments by accessing relevant genetic information that can have a meaningful impact on patient care at a personalized level.” Brille , Vice Chairman of Caris Life Sciences.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

Roots Analysis

MARCH 1, 2023

Genotoxicity testing refers to the evaluation of detrimental effects of chemical or physical agents on the genetic processes and related hereditary material of living cells. Mechanism of Genotoxicity / Mutagenicity The interaction of genotoxins / mutagens with the structure of DNA causes damage to the genetic material.

Genotoxicity 52

Genotoxicity DNA Genetics Bacteria 52

Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. Gene switches can be regulatory proteins or specific DNA sequences that act to either switch on or off the expression of a gene. These genetic switches assist transcription factors in binding to the promoter region.

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Gene Gene Therapy Gene Expression Regulation 40

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. Their functions such as carrying oxygen, providing structural support to cells, transmitting biological processes to cells, and fighting viruses and bacteria, are essential to human health.

RNA 52

RNA Protein Vaccination Vaccine 52

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g., Herpesviridae, Polyomaviridae, and Papillomaviridae), bacteria (e.g.,

DNA 98

DNA Genome Genomics RNA 98

pharmaphorum

SEPTEMBER 14, 2020

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. While it is a very rare form of epilepsy, it is such a cheap and harmless medication that it is often used as a first-line therapy for infants in intensive care who have no genetic diagnosis.

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Genome Genomics Medicine Gene 108

Drug Discovery World

JULY 26, 2023

With 100-fold the number of genes in the human genome 1 , this microbial collection is a rich genetic signature of clinical significance that we have only recently gained the tools to explore. Genome editing tools such as CRISPR may be employed to create “live biotherapeutics” (drugs composed of living bacteria).

Medicine 52

Medicine Genome Genomics Bioinformatics 52

The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens.

Marketing 52

Marketing In-Vitro DNA Bacteria 52

The Pharma Data

JANUARY 21, 2021

The test valuates mitochondrial DNA levels. When mitochondrial DNA, normally found inside cells, in the mitochondria, spills into the bloodstream, it signals that a particular type of violent cell death is occurring. They measured the patients’ mitochondrial DNA levels on the first day of their hospital stays.

Research 52

Research DNA Hormones Vaccination 52

Drug Discovery World

AUGUST 10, 2022

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. Cells from solid tumours are genetically heterogeneous both between and within tumours, making it challenging to identify a single, selective antigen target for treatment.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

XTalks

DECEMBER 22, 2021

RNA therapeutics hold promise as powerful treatments for diseases, including those that are genetic-based. The gene-editing tool CRISPR edits DNA using specialized strands of guide RNA and endogenous cellular mechanisms of RNA interference. RNA Therapeutics. The deal is worth $1.5 Prior to this, Lilly struck an agreement worth $1.25

Life Science 98

Life Science RNA Vaccination Vaccine 98

XTalks

DECEMBER 24, 2020

However, for virologists like Lori Frappier, PhD, professor in the department of molecular genetics at the University of Toronto, the outbreak of SARS-CoV-2 was less of a surprise and more of an inevitability. The system can be used to precisely edit out portions of DNA flanked by CRISPR sequences.

Life Science 111

Life Science Vaccination Vaccine Gene 111