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World’s largest catalogue of ocean DNA could boost drug discovery

Drug Discovery World

Scientists at the King Abdullah University of Science and Technology (KAUST) in Thuwal, Saudi Arabia used the KAUST Metagenomic Analysis Platform (KMAP) to analyse massive amounts of sequencing data to release Global Ocean Gene Catalog 1.0.

DNA 103
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CRISPR pioneers Doudna and Charpentier claim Nobel chemistry prize

pharmaphorum

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. What started as a curiosity?driven,

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Global advances in synthetic biology

Drug Discovery World

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

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Could Fluoride be the Solution to Antibiotic Resistance? A New Study Weighs In

The Pharma Data

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. The UC Santa Barbara research uses a method that addresses not only antibiotic overuse, but also the containment of genetically modified organisms (GMOs). “If

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New CRISPR-Based Tool Called PASTE Gene Editing Inserts Large DNA Sequences at Desired Sites

XTalks

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

million data points from ALS patient tissue and genetics datasets to discover loss of endolysosomal function as a new causative mechanism in ALS, and uncovered PIKfyve as a promising new therapeutic target. In June 2023, lab automation company Opentrons launched its Flex robots for scientists using generative AI. Obulytix is not alone.

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Women in Science Who Have Paved the Way Forward in Genetics

XTalks

This has ushered in a new era of genomics that is fostering rapid, detailed and personalized insights into human genetics. Xtalks is celebrating the International Day of Women and Girls in Science with a special overview of notable female scientists who have made revolutionary contributions to the field of genetics.

Genetics 119