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US researchers decipher how one gut bacterium influences immunity

Drug Discovery World

A team led by researchers at HMS and the Broad has just accomplished the rare feat of connecting those dots for one important gut bacterium. The researchers show in a report published July 27 in Nature that the links begin with a lipid—a fat—in A. The work introduces new possibilities for developing drugs that piggyback on A.

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Bacterial infection may be a “key event” in triggering endometriosis development

Pharmaceutical Technology

In a study published in Science Translational Medicine , researchers from Japan’s Nagoya University documented how Fusobacterium may play a key role in spurring the development of endometriosis. In the above-mentioned study, researchers documented how Fusobacterium might stimulate the development of endometriosis.

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Solving a mystery: How the TB bacterium develops rapid resistance to antibiotics

Scienmag

Credit: SDSU For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.

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Researchers develop a new technique to treat middle ear infections

Scienmag

In a new study, researchers have designed a miniaturized 3D-printed device to inactivate Pseudomonas aeruginosa, a common bacterium that causes the infection. Credit: Jungeun Won Middle ear infections, also known as otitis media, affect more than 80% of the children in the U.S.

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Researcher receives grant to develop improved Lyme disease diagnostics and therapeutics

Scienmag

Lyme disease is carried by black-legged ticks and infects people when they are bitten and transmit the bacterium Borrelia burgdorferi. Black-legged ticks are especially common in the northeastern United States, and people are exposed to the ticks usually during outdoor activities.

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Human infection model drives forward TB vaccine development

Drug Discovery World

For the first time, a controlled human infection model for tuberculosis (TB) has been developed and could help with the future development of TB vaccines. Human challenge models have contributed significantly to the development of vaccines for diseases such as malaria or typhoid, especially in early phase trials.

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Scientists make critical progress toward preventing C. diff infections

Medical Xpress

diff infection caused by multiple strains of the bacterium, including those that cause serious illness. Researchers are now using this compound to develop new drug candidates that might eventually offer a way to prevent serious C. A new study performed in mice has identified a compound that prevented C.