Drug Discovery World

SEPTEMBER 7, 2022

Conventional bioassays rely on enzyme or fluorescent labels to detect biomolecular interactions. The latest Creoptix eBook reveals the challenges presented by conventional label-based bioassays and explores how label-free interaction analysis can deliver a world of insight. Access the ebook here.

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Pharmaceutical Technology

FEBRUARY 15, 2023

“At the small scale, manufacturing between 1 ml and 10 ml is typically not problematic , but it’s not straightforward to replicate processes and technologies once you want to produce tens of litres of formulations,” says Dr Crowe, who manages a team that develop novel analytical assays related to LNPs and nanomaterials for drug delivery.

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Drug Discovery World

APRIL 10, 2024

It will take place on 2 May at 3pm BST, 10am EDT, 4pm CEST and will be presented by Ron Morena, Manager in Analytical Bioassay at Tanvex Biopharma CDMO, along with and Dr Neha Mishra, Senior Scientist in the BioProduction R&D team, Revvity. Characterizing binding properties of complex biomolecules is a critical step.

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Pharmaceutical Technology

OCTOBER 12, 2022

As part of the collaboration, Toregem will use WuXi Biologics’ integrated CMC services in cell culture development, cell line development, bioassay development, biologics GMP manufacturing, cell banking and testing services, as well as other related services. TRG035’s Phase I clinical study is scheduled to begin in early 2024.

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Drug Discovery World

AUGUST 1, 2023

Using multiple bioassays to gain insights on the effects of the CATCH regimen on different types of immune cells, the researchers showed that their strategy not only reactivated the cycle but also removed obstacles at other stages. The post RNA-based immunotherapy eradicates melanoma tumours appeared first on Drug Discovery World (DDW).

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RNA Bioassay Genome Genomics 52

Drug Discovery World

MARCH 8, 2023

New projects will sit alongside the Alliance’s current portfolio of projects, now overseen by Dr Hall, which includes the IDMP Ontology Project, DataFAIRy Bioassay Annotation Project and Diversity & Inclusion in STEM Leadership program. A global initiative The inaugural meeting of the Council took place in January 2023.

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pharmaphorum

AUGUST 5, 2021

Understanding the mechanism of PPIs and developing methods to target aberrant ones has been a key strategy in drug development. In comparison with the classic, small molecule drug discovery approach, the modulation of PPIs is more challenging. Current challenges and conventional approaches in targeting PPIs. Charlotte Di Salvo.

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Drug Discovery World

FEBRUARY 23, 2023

For decades, drug discovery and development have been constrained by limits in our knowledge of the relationship between protein sequence, structure and function, and the methods available to explore novel drug targets. Proteins are the basic building blocks and engines of biology.

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Protein Life Science Bioassay Development 52

Drug Discovery World

AUGUST 12, 2022

millimolar solution for a bioassay or a milligram amount of a reactant for a synthesizer could have detrimental skewing effects on a derived dose response curve or could lead to an unbalanced reaction. The post Addressing the challenge of salt forms in drug discovery appeared first on Drug Discovery World (DDW). References.

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Drugs Bioassay Development Research 52

Drug Discovery World

MAY 4, 2023

Professor Sonika Bhatnagar explores how artificial intelligence is enabling drug discovery at rates never seen before. Here started the story of drug discovery. The magic bullet was the drug, while the specific mark it would reach in the syphilis causing bacteria to eliminate the disease was the drug target.

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Medicine Protein Drugs Bioassay 52

Drug Discovery World

JANUARY 19, 2023

However, standard technologies used to ensure the highest value cells are progressed require multistep operations and instruments, extensive hands-on time, and lengthy liquid handling processes, as well as complex, low throughput bioassays for functional validation and verification.

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Drug Discovery World

MAY 10, 2023

Dr Megan MacBride and Dr Caroline Horizny Mitchell , Taconic, examine recent changes to animal testing in drug design. Drug discovery and development is an arduous process that can cost upwards of $2.6 In August 2022, the ICH issued an addendum to its S1B guidelines that allows certain drugs to forego two-year rat studies 1.

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Drug Discovery World

NOVEMBER 9, 2023

The first three include: Sungjin Park, PhD, CEO, Onegene Biotechnology, on: ‘UniStac: Enzyme-mediated conjugation technology for accelerated development of tetraspecific NASH drug’. Ioanna Stamati, PhD, Team Leader, Bioconjugation, Antikor Biopharma, on: ‘Antibody fragment drug-conjugates (FDCs): Analysing novel formats with high DAR’.

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Engineer Antibody Protein In-Vivo 52

Drug Discovery World

NOVEMBER 30, 2023

This conditional activation is intended to focus immune attack more specifically against tumour cells and minimise damage to healthy cells, a major challenge for current oncology drugs and development efforts. The post Reflecting on PEGS Europe 2023 appeared first on Drug Discovery World (DDW).

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Antibody Protein Engineer In-Vivo 59

The Pharma Data

MAY 13, 2021

Nat Rev Drug Discov. The obesity epidemic and food addiction: clinical similarities to drug dependence. J Psychoactive Drugs. Curr Drug Abuse Rev. Addicted to Palatable Foods: Comparing the Neurobiology of Bulimia Nervosa to that of Drug Addiction. Aspartame bioassay findings portend human cancer hazards.

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Insulin Production Hormones Medicine 52

Pharmaceutical Technology

JANUARY 6, 2023

Cambrex performs validated IVRT on product development batches and also offers a range of bioassays to demonstrate product potency when applicable. Microbial bioassay – measures the potency of a biological active substance (e.g., Fixed dose combination drugs: Case study. In vitro release testing to demonstrate bioequivalence.

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