Pharmaceutical Technology

AUGUST 10, 2022

The takeover of Metrics will bolster the expertise of Catalent in the development of integrated oral solid formulation, production and packaging to aid customers in streamlining and expediting their programmes. It will also aid in expanding the capacity of Catalent to manage highly potent compounds.

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Packaging Packaging Bioavailability Manufacturing 147

Pharmaceutical Technology

JUNE 13, 2023

Windtree Therapeutics noted that these product candidates are intended to be both oral and IV therapies. Dual mechanism SERCA2a activators work by inhibiting the Na+/K+ pump [an enzyme found in the membrane of all animal cells] and activating SERCA2a.

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Bioavailability Protein Drugs Development 130

XTalks

DECEMBER 5, 2022

Clinical-stage biotech company PureTech Health has announced it has developed a new oral CBD therapeutic candidate with improved bioavailability and tolerability, which could expand use of the CBD prodrug in a wide range of indications and age groups. Meanwhile, net product sales of Epidiolex grew by 22 percent to $196.2

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Bioavailability FDA Approval Trials Drugs 97

Pharmaceutical Technology

MAY 8, 2023

The China National Medical Products Administration (NMPA) has granted approval for BeiGene’s four applications for Brukinsa (zanubrutinib). The small molecule Bruton’s tyrosine kinase (BTK) inhibitor Brukinsa has been specially designed for delivering sustained BTK protein inhibition by optimising bioavailability, half-life, and selectivity.

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Pharmaceutical Technology

JANUARY 20, 2023

BeiGene has received marketing authorisations for Brukinsa (zanubrutinib) in Great Britain from the Medicines and Healthcare products Regulatory Agency (MHRA) to treat chronic lymphocytic leukemia (CLL) and marginal zone lymphoma (MZL).

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Pharmaceutical Technology

APRIL 20, 2023

It also aims to contribute to the pharmaceutical sector by facilitating cross-industry partnerships and research-based product development. The facility complements the company’s current pharma innovation centres in France and Singapore, and intends to improve the patient experience with modern oral dosage forms.

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Bioavailability Manufacturing Scientist Development 130

Camargo

DECEMBER 22, 2021

One of Camargo’s differentiating offerings is the portfolio analysis, a high-level, integrated evaluation of the scientific, medical, regulatory, and commercial viability of each product within a sponsor’s portfolio. Each product is unique, and so is the associated development strategy. Why Conduct a Portfolio Analysis?

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Bioequivalency Production Genotoxicity In-Vivo 169

Pharmaceutical Technology

SEPTEMBER 23, 2022

Current treatment options for DES are dominated by a mix of prescription and over-the-counter (OTC) products. GlobalData anticipates CyclASol to be positioned as the superior cyclosporine due to its favorable tolerability profile and better bioavailability, with the potential to capture market share from other cyclosporine-based therapies.

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Development Drugs Clinical Trials Clinical Trials 147

The Pharma Data

JANUARY 7, 2021

The pharmaceutical product landscape is rapidly and fundamentally changing with profound impact on research and development strategy and technology needs. The number of biopharmaceutical products show a considerable growth accounting for nearly a quarter of the new molecular entities approved in 2017.

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Bioavailability Production Manufacturing Drugs 52

Roots Analysis

FEBRUARY 20, 2022

In fact, it has been observed that around 40% of the pharmaceutical products approved by regulatory organizations exhibit poor bioavailability / solubility. Further, every year, poor bioavailability is one of the prime reasons that leads to failure in obtaining approval authorization. Nanoparticles Contract Manufacturing.

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Contract Manufacturing Bioavailability Manufacturing Drug Delivery Systems 52

Drug Discovery World

NOVEMBER 27, 2023

The Chinese National Medical Products Administration (NMPA) has granted conditional approval to Apollomics’ partner Avistone Biotechnology to commercialise vebreltinib (APL-101) in China for MET exon 14 skipping non-small cell lung cancer (NSCLC).

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Bioavailability Clinical Trials Clinical Trials Trials 52

Drug Discovery World

DECEMBER 16, 2022

The proceeds from the financing will support the ongoing multiple-ascending dose trial of STC-15 and further facilitate Storm as we advance our pipeline of products.” . Initial results are anticipated to be presented in 2023. .

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RNA Immune Response Bioavailability Development 52

Cloudbyz

MARCH 5, 2024

The difference between biologics vs small molecules in pharma drug development In pharmaceutical drug development, biologics and small molecules represent two distinct categories of medicinal products, each with their own unique characteristics, development processes, and mechanisms of action.

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Development Drugs Manufacturing Immune Response 77

Pharmaceutical Technology

AUGUST 22, 2022

When it comes to pharmaceutical, nutritional or cosmeceutical dosing, some of the most crucial parameters are safety, product effectiveness and patient adherence. They also offer enhanced bioavailability, exact dosing and an extended shelf life.

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Compliance Bioavailability Containment Branding 130

XTalks

JUNE 14, 2023

Novaliq, a biopharmaceutical company specializing in ocular therapeutics, recently announced that their product Vevye (cyclosporine ophthalmic solution) 0.1 Furthermore, the bioavailability of the active pharmaceutical ingredient (API) into the cornea is up to four times stronger with EyeSol technology.

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Gene Silencing Drug Delivery FDA Approval RNA 97

pharmaphorum

JANUARY 16, 2023

Rykindo is something of a pathfinder product for Luye Pharma, however, and will allow the Chinese company to build a commercial presence in the US antipsychotics market as it brings forward its own pipeline of longer-acting candidates for schizophrenia and bipolar disorder.

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FDA Approval Drugs Bioavailability Marketing 52

pharmaphorum

AUGUST 19, 2022

” Grünenthal already sells a topical capsaicin product called Qutenza for post-shingles nerve pain and diabetic nerve pain affecting the feet, and recently started a phase 3 trial that aims to extend its indications to include post-surgical neuropathic pain.

Drugs 52

Drugs Bioavailability Trials Clinical Development 52

Roots Analysis

MARCH 2, 2022

One of the key objectives behind the aforementioned developments is to overcome issues related to high costs associated with the design and production of such pharmacological interventions. Over 40 oral drug delivery technologies have been designed so far. For further information on this domain, check out the report –. Web: [link].

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Protein Drug Delivery Drugs Drug Delivery Systems 52

Roots Analysis

OCTOBER 2, 2023

Additionally, it increases the bioavailability and solubility of the attached molecule. It also helps companies to reduce the costs associated with research and development and speed up the time to market new products.

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Drug Delivery Drugs Bioavailability Marketing 40

XTalks

APRIL 11, 2023

These neurons produce dopamine, so their death results in lowered dopamine production and subsequently movement issues. By avoiding the stomach entirely, there is increased bioavailability and more sustained relief from symptoms. ND0612 is currently in Phase III of clinical development and is supported by four years of safety data.

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Bioavailability Genetics Nurses Development 98

Camargo

JULY 8, 2021

As required by components of the 21 st Century Cures Act and the FDA Reauthorization Act, the FDA has sought to promote Patient-Focused Drug Development considerations into regulatory decision making, including product application approvals. FDA Publishes Draft Guidance on Adverse Drug Experience Reporting for INDs and BA/BE Studies .

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Development Bioequivalency Gene Expression Drugs 130

The Pharma Data

JANUARY 5, 2021

They indicate that the potential benefits over current protein and RNA-based approaches are “potency, selectivity, oral bioavailability, tissue distribution and central nervous system penetration.”. It has state-of-the-art proprietary assays to identify ligands that bind specifically to the structural pockets in many RNA molecules.

RNA 52

RNA Protein Bioavailability DNA 52

XTalks

FEBRUARY 3, 2023

Current treatments include hormonal therapies that focus on blocking the function of the estrogen receptor, curbing its production or degrading the receptor itself. Mutations in the ESR1 , however, have contributed to the rise of endocrine resistance. Orserdu is available in the form of 345 mg tablets to be taken once a day with food.

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Clinical Trials Clinical Trials FDA Approval Trials 97

Drug Discovery World

JULY 25, 2023

Long term clinical neurodevelopment safety studies The FDA has issued guidance for developing long-term clinical neuro-developmental safety studies for products intended for neonates. The goal of these studies is to inform the safety of neonatal product development and improve outcomes for this vulnerable population.

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Development Drugs Medicine Production 52

Roots Analysis

MARCH 13, 2022

In fact, over 8,000 biological pharmaceutical products are currently under clinical investigation worldwide. Furthermore, excipients play a critical role in biologics development by enhancing the solubility and bioavailability, controlling pH and tonicity of the active pharmaceutical ingredients (APIs).

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Manufacturing Drug Delivery Marketing Drug Delivery Systems 52

The Pharma Data

NOVEMBER 19, 2020

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. This press release contains forward-looking statements, including statements about the discovery, development and commercialization of products.

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Development Bioavailability Production Drugs 40

Roots Analysis

SEPTEMBER 1, 2023

The strategy involves creating an entirely new demand for products or services, transcending the constraints of existing demand. By altering the formulation of a drug, pharmaceutical companies can improve its bioavailability, stability, and solubility, leading to better absorption and distribution in the body.

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Drug Delivery Marketing Drug Delivery Systems Drugs 52

The Pharma Data

JANUARY 3, 2021

to have in place 25 operating production lines of which 5 to 10 are expected to be GMP production lines. Nanoform’s capabilities span the small to large molecule development space and the company focuses on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.

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Containment Bioavailability Clinical Trials Clinical Trials 52

Pharmaceutical Technology

MAY 31, 2023

CFT8919 is an orally bioavailable BiDAC degrader designed to exhibit potent and selective activity against EGFR L858R in patients with non-small cell lung cancer (NSCLC). C4T can also earn up to $357m in milestone payments and receive low to mid-double-digit percentage royalties on net sales of the product in greater China.

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Bioavailability In-Vivo In-Vitro Licensing 130

Delveinsight

FEBRUARY 16, 2021

With damages to the bone marrow, the production and normal functioning of red blood cells, white blood cells, and platelets get hampered. Maribavir is an orally bioavailable anti-CMV compound. Chemotherapy drugs while killing cancer cells also damages normal tissues. The bone marrow is particularly vulnerable in this case.

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Marketing Protein Bioavailability Drugs 52

The Pharma Data

NOVEMBER 22, 2020

About EZEPROGIND (AZP2006): Alzprotect is developing a drug candidate, EZEPROGIND, whose mode of action, acting on Progranulin secretion, is clearly different from other products developed in the past 15 years by the pharmaceutical industry. EZEPROGIND, which is kicking off phase 2a trials, is a bioavailable neurotrophic inducer.

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Drugs Protein Bioavailability Development 40

Delveinsight

AUGUST 10, 2020

Nintedanib is an orally bioavailable, small-molecule tyrosine kinase inhibitor (TKI) developed for the treatment of IPF and SSc-ILD. Boehringer Ingelheim is worth mentioning here, as it is presenting key posters and studies on Ofev’s SENSCIS Trial and INBUILD Trial. Ofev (Nintedanib) Facts. Esbriet (Pirfenidone) Facts.

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Drugs Trials Bioavailability FDA Approval 52

Delveinsight

JANUARY 7, 2021

Ribometrix will also be eligible to obtain potential milestone payments exceeding USD 1 billion and tiered royalties on future global net sales of products that ensue from the collaboration. Ribometrix has presented that many RNAs implicated in disease comprise structural pockets amenable to targeting with small molecules.

RNA 52

RNA Clinical Trials Clinical Trials Bioavailability 52

The Pharma Data

DECEMBER 9, 2020

Artificial intelligence holds immense promise to catalyze the development of the next generation of highly selective, orally bioavailable molecules, with reduced side effects, for the most impactful drug targets,” Feinberg said at the time of the launch. It’s like taking out the trash.

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Marketing In-Vivo Protein In-Vitro 52

The Pharma Data

JANUARY 20, 2021

Calliditas’ lead product candidate, Nefecon, is a proprietary, novel oral formulation of budesonide, an established, highly potent local immunosuppressant, for the treatment of the autoimmune renal disease IgA nephropathy, or IgAN, for which there is a high unmet medical need and there are no approved treatments.

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Trials Containment Clinical Trials Clinical Trials 52

Drug Discovery World

DECEMBER 7, 2022

However, developing and bringing new small molecule products to market is fraught with challenges, and the failure rate remains high, driven primarily by later-stage efficacy, safety, and solubility concerns. While a candidate molecule’s chemical structure is a critical determinant of such characteristics, it isn’t the only one.

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Bioavailability Manufacturing Production Development 52

Pharmaceutical Technology

NOVEMBER 24, 2022

At Quotient Sciences, our state-of-the-art facilities follow cGMP guidelines for the production of 14 C-labeled pharmaceuticals for human investigations and are accredited by the UK Medicines and Healthcare products Regulatory Agency (MHRA). How does your unique Synthesis-to-Clinic® offering streamline the drug development process?

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