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Leveraging Genetic Testing for Enrolling Rare Disease Trials

Worldwide Clinical Trials

Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. One diagnostic example that I discussed in my presentation is autism.

Genetics 184
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Scientists Discover a Genetic Variant That Seems to Limit HIV Infection

AuroBlog - Aurous Healthcare Clinical Trials blog

Now an international team of researchers has discovered a new genetic variant in people of African ancestries that appears to restrict HIV replication after an infection sets in. Though more research is needed to confirm their findings, the […]

Genetics 215
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Genetic diagnostics promises paradigm shift towards personalized, proactive healthcare

AuroBlog - Aurous Healthcare Clinical Trials blog

Indian healthcare industry is of the view that emergence of genetic diagnostics will be a paradigm shift towards personalized medicine. Through the ever-evolving landscape of healthcare, the role of genetic diagnostics offers personalized insights and proactive solutions for disease management and prevention.

Genetics 158
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Risk Assessment for use of Engineered Genetic Materials in Clinical Research

Advarra

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials.

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Cleveland Clinic research suggests tumors with specific genetic mutations are sensitive to immunotherapy

Scienmag

July 11, 2022, CLEVELAND: New research from Cleveland Clinic is demonstrating that pathogenic polymerase epsilon and delta (POLE/POLD1) genetic mutations lead to improved response to immune checkpoint blockade, a powerful class of immunotherapy drugs.

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Study shines a light on representation in clinical research

Drug Discovery World

The post Study shines a light on representation in clinical research appeared first on Drug Discovery World (DDW).

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We’ve Discovered A Subtle Genetic Imbalance That May Drive Aging

AuroBlog - Aurous Healthcare Clinical Trials blog

Scientists have found an extremely subtle twist in the genetics of aging cells, one that seems to make them increasingly less functional as time goes on.

Genetics 174