Drug Discovery World

FEBRUARY 6, 2024

Her current work focuses on advancing the fields of genome sequencing and analysis, with an emphasis on identifying complex structural variation. She speaks to Megan Thomas on how genomics can advance drug discovery and development. MT: Where is technology being implemented to progress the drug discovery process?

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Drug Discovery World

FEBRUARY 6, 2024

As AI-designed drugs start to enter large-scale clinical trials, DDW’s Diana Spencer investigates how new digital tools are reinventing and reshaping drug discovery for the future. Automation is also being applied to genomics sample preparation, an area that requires particular robustness and scalability.

Marketing 69

Marketing Medicine Genome Genomics 69

Drug Discovery World

FEBRUARY 12, 2024

“In the upcoming year, we will see the expansion of new, more complex markets and updated requirements from regulators. Without fixing the current, broken PV models, the continuous cycle of more complexity in the market, which then pushes organisations to incorporate automation into insufficient processes, will massively hinder PV operations.

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The Pharma Data

JANUARY 26, 2021

offered its genomics expertise to identify emerging variants of the SARS-CoV-2 virus to countries that lack the resources to make such identifications. has carried out more than half of all SARS-CoV-2 genome sequences submitted to the global database. On Tuesday, the U.K. The offer came as part of the U.K.’s South Africa and Brazil.

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Pharmaceutical Technology

NOVEMBER 8, 2022

With the takeover, Fulgent Genetics intends to transform into a completely integrated precision medicine firm focusing on oncology from a genomic diagnostic business. Fulgent Genetics has a significant presence in the molecular diagnostics and oncologic testing market. Fulgent Pharma focuses on developing cancer therapies.

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Pharmaceutical Technology

JUNE 29, 2022

Orphan drug designations provide financial incentives for companies and developers, including “tax credits for qualified clinical testing”, “a Waiver of the Prescription Drug User Fee” that is currently at almost $3 million for a new drug, and “potential seven years of market exclusivity”.

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Pharmaceutical Technology

FEBRUARY 13, 2023

The multimodal approach will combine radiomics analysis of molecular data, medical imaging data, digital pathology, and clinical and biologic data for a comprehensive evaluation of multimodal signatures using AI and machine learning technology.

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Genetics Development Drugs Genome 130

Pharmaceutical Technology

JULY 29, 2022

CAMP4’s CSO David Bumcrot PhD tells Pharmaceutical Technology that the company plans to see clinical trials go forward for their urea cycle disorder programs late next year. The most common marketed drugs in this space aim to address the hyperammonaemia caused by the defective genes in this disorder.

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The Pharma Data

DECEMBER 9, 2020

Hepion will also conduct Fibroscans and examine a multitude of candidate biomarkers of NASH resolution and CRV431 efficacy including Pro-C3, Enhanced Liver Fibrosis (ELF) markers, collagens, matrix metalloproteinases, transcriptomics, liver transaminases, and full-scale lipidomic and genomic signatures.

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Clinical Trials Clinical Trials Trials Genome 40

Drug Discovery World

APRIL 3, 2023

Panna Sharma will discuss some of the use-cases of NGS in developing oncology targets and the benefits and challenges we’re seeing in regard to the technology’s use. NGS has transformed the genomics market from basic research to the clinic, and so Dr Budel and Dr Edwards’ presentation will focus on the pivotal role NGS plays at various developmental (..)

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RNA Drugs Genome Genomics 52

pharmaphorum

JUNE 23, 2022

billion in potential milestones if the project advances through development and onto the market. The deal comes a year after Intellia and partner Regeneron reported promising results from the first clinical trial of a drug used to edit the genomes of cells within the body, in patients with rare disease ATTR amyloidosis.

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The Pharma Data

DECEMBER 17, 2020

In a pivotal head-to-head Phase III SOPHIA clinical trial, it became the first HER2-targeted therapy to improve progression-free survival (PFS) versus Herceptin® (trastuzumab), when each was combined with chemotherapy. at the time of the announcement. The product launch is expected to take place in March of 2021. Athenex, Inc.

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Drug Discovery World

APRIL 18, 2023

Register now. The post Register now to learn how NGS is informing oncology drug discovery appeared first on Drug Discovery World (DDW).

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RNA Drugs Genome Genomics 52

Pharmaceutical Technology

DECEMBER 14, 2022

The alliance will merge the PRISM oligonucleotide platform of Wave and the capabilities of GSK in genetics and genomics. On completion of the first-in-patient clinical trial by Wave, GSK will be in charge of the development and marketing works. Wave will also receive royalty payments for this programme.

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Drug Discovery World

APRIL 11, 2023

Register now. The post Webinar: Find out how NGS is informing oncology drug discovery appeared first on Drug Discovery World (DDW).

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RNA Drugs Genome Genomics 52

Drug Discovery World

MARCH 13, 2024

According to Statista, revenue in this sector is expected to grow at an annual rate of 6.77%, resulting in a market volume of US$2,208m by 2028 1. Singapore is also leading the way in genomics, having founded The Genome Institute of Singapore as far back as 2000.

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Life Science Genome Genomics Research 69

Roots Analysis

JANUARY 22, 2024

This resulted in the discovery of an individualized concept of treatment known as oncology precision medicine which primarily utilizes the patient’s genomic information to provide gene-targeted diagnostics and therapeutics. Data Handling: Genomic data essential for the implementation of precision medicine is highly sensitive and personal.

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Medicine Genetics Genome Genomics 40

pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

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Gene Editing Gene Gene Therapy In-Vivo 145

Drug Discovery World

APRIL 4, 2023

Register now. The post Next-generation sequencing and oncology drug discovery appeared first on Drug Discovery World (DDW).

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Drugs RNA Genome Genomics 52

Drug Discovery World

DECEMBER 21, 2023

Regulatory issues and diversity in clinical trials were also important in 2023, as well as the role that artificial intelligence tools like ChatGPT might play. A Nature publication confirmed that there are currently 12 FDA-approved ADCs on the market, and nine of these secured FDA approval in the past six years.

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Gene Therapy Gene Antibody FDA Approval 59

Drug Discovery World

AUGUST 24, 2023

This is the latest episode of the free DDW narrated podcast, “What lies in the future for genomics and big data?”, In the first article, DDW’s Lu Rahman takes a snapshot of the US biotech market and how its successes are having a positive effect on its UK counterpart.

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Big Data Drugs Genome Genomics 52

The Pharma Data

DECEMBER 28, 2020

Despite the challenges of conducting a clinical trial during the COVID-19 pandemic, we continue to make good progress.” Two interim analyses were performed by a DSMB to evaluate the safety and tolerability of the 75 mg CRV431 dose cohort in NASH patients. ” About Hepion Pharmaceuticals.

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Drug Discovery World

MAY 6, 2024

billion on R&D during 2021, with Germany and Switzerland being the biggest contributors, and around one fourth of clinical trials worldwide were performed in Europe 1. During the period 2016-2021, the Brazilian, Chinese and Indian markets grew by 11.7%, 6.7% respectively compared to an average market growth of 5.8%

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Drugs Life Science Gene Editing Gene 59

Drug Discovery World

APRIL 24, 2023

Register now. The post Free webinar today: How is NGS informing oncology drug discovery?

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RNA Drugs Genome Genomics 52

pharmaphorum

JANUARY 24, 2022

The sale also marks a retreat from healthcare for the tech giant, which is remarkable given that it once said it viewed health as second only to financial services market as a market opportunity. IBM said it “remains committed to Watson, our broader AI business, and to the clients and partners we support in healthcare IT.”

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Radiology Marketing Genome Genomics 111

Drug Discovery World

JULY 10, 2023

Think how cell and gene therapies or monoclonal antibodies have become targeted medicines for cancer and you’ll get an idea of the shifting pharmaceutical market. Its convergence with genomics makes sense and we have now multiple examples of AI being used to inform prescribing, diagnostics and drug discovery/ development.

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pharmaphorum

APRIL 23, 2020

You can listen to our March webinar here: [link] Focus During the April instalment, our expert panel will discuss: •Assessing the pharmaceutical market impact of COVID-19 •The UK clinical trials on COVID-19: navigating uncharted waters •Genomics: research in the time of COVID-19 •Knowledge sharing: the COVID-19 experience from a US perspective •Getting (..)

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Drug Discovery World

MARCH 2, 2023

” The role of AI in rare disease clinical trials might hold the key to helping the UK achieve this vision. AI is revolutionising clinical trials and drug developments just as it is transforming other sectors, but in order for AI to make progress in rare diseases, the UK needs further investment to increase uptake and use.

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XTalks

APRIL 21, 2023

The application of whole genome sequencing (WGS) to derive a more complete understanding of cancer has been a central goal of cancer researchers even before the first human genome was decoded in 2003. Ultima Genomics has already partnered with other leading biotech startups.

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Drug Discovery World

MARCH 30, 2023

Likang Life Sciences has been granted implied approval by China’s National Medical Products Administration (NMPA) for the clinical trial of its innovative personalised neoantigen-targeted vaccine LK101 Injection for advanced solid tumours. Vaccines predicated on neoantigens therefore elicit truly tumour-specific T cell responses.

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XTalks

APRIL 24, 2023

Melanie Blank, clinical team leader for General Medicine Branch 1 at the US Food and Drug Administration’s (FDA) Division of Clinical Evaluation and Pharmacology/Toxicology (DCEPT), the agency is seeing one or two new applications coming in every week for new gene therapies for different diseases. Reference: Chung DC, et al.

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Drug Discovery World

FEBRUARY 6, 2023

The company is co-founded by former team leaders and multi-disciplinary tool builders from 10x Genomics. MT: Can you provide me with an overview of what Infinimmune does currently and the potential it sees in the antibody-based therapeutics market? We do this by studying B cells from human blood and tissue.

Antibody 52

Antibody Immune Response Genome Genomics 52

XTalks

DECEMBER 4, 2023

In a statement outlining its investigation, the FDA said it received reports of the T-cell malignancies from clinical trials and post-marketing safety monitoring. The vectors can potentially cause cancer by inserting genetic material into a patient’s genome, particularly near cancer-related DNA sequences or suppressors​​​​.

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Gene Therapy Gene Clinical Trials Clinical Trials 69

The Pharma Data

DECEMBER 30, 2020

The companies agreed to the steep price cuts in order to have their drugs made available to the world’s second-largest pharmaceutical market. The company’s product candidate is targeting the global metastatic cancer treatment market, projected to be worth $111.2 Surufatinib will be marketed in China under the brand name Sulanda.

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The Pharma Data

DECEMBER 14, 2020

The global GBM treatment market is projected to reach $3.3 representing the largest market. Many drugs fail in clinical trials because of their low blood brain barrier permeability. Many drugs fail in clinical trials because of their low blood brain barrier permeability. Lantern’s A.I.

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XTalks

OCTOBER 20, 2023

Clinical-stage genome editing company Intellia Therapeutics has received clearance from the US Food and Drug Administration (FDA) for its Investigational New Drug (IND) application to start a pivotal phase III trial of NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy.

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The Pharma Data

OCTOBER 19, 2020

With over 300 active clinical trials, Winship researchers are dedicated to taking new cancer treatments from bench to bedside. cancer centers selected as a Lead Academic Participating Site for the NCI’s National Clinical Trials Network (NCTN). Winship is one of 32 U.S.

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