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US FDA clears Transcenta’s IND for Rett syndrome treatment

Pharmaceutical Technology

The investigational adeno-associated virus (AAV) gene therapy candidate NGN-401 is claimed to be the first to deliver the full-length human MECP2 gene using the company’s Expression Attenuation via Construct Tuning (EXACT) gene regulation technology.

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Researchers teach AI to tailor artificial DNA for drug development

Drug Discovery World

Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . The technology can contribute to the development and production of vaccines and drugs for severe diseases much faster and at lower cost. .

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Gene Switch: A Novel Platform for Switching Genes On and Off

Roots Analysis

Further, the transcription factors contain two molecular domains, the DNA binding domain and the activation domain. Moreover, some transcription factors contain additional domains, such as ligand binding domain in order to interact with chemical signals.

Gene 40
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Symvivo’s Oral COVID-19 Vaccine Enters Clinical Trials

XTalks

DNA vaccines designed using the platform consist of a combination of an advanced gene expression plasmid (pDNA) with gene(s) of interest, and a probiotic bacterium to deliver the vaccine directly to the gut, where it binds to intestinal epithelial cells.

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Nutrigenomics: The Future of Personalized Nutrition

Roots Analysis

At present, extensive studies are being conducted to understand the interaction between nutrients and gene expression at the molecular level, to determine the effect of a specific nutrient and dietary regime on human health. For example, people affected by phenylketonuria must avoid consuming food containing phenylalanine amino acid.

Genome 40
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Tezepelumab NAVIGATOR Phase 3 Trial Met Primary Endpoint Of A Statistically Significant And Clinically Meaningful Reduction In Exacerbations In A Broad Population Of Patients With Severe Asthma

The Pharma Data

Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans.

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Fulcrum Therapeutics Announces Pricing of Public Offering of Common Stock – Jan 20, 2021

The Pharma Data

Fulcrum’s proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression. Forward-Looking Statements. Actual results may differ materially from those projected or implied in these forward-looking statements.