Drug Discovery World

FEBRUARY 12, 2024

Dr Pandora Pound , Fellow Oxford Centre for Animal Ethics explores the hinderances of animal testing in pharma and why new technologies such AI, genomics and synthetic biology c an further drug development. Why has there been so little progress in medicine? Why has it been so unproductive?

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Medicine Genome Genomics Drugs 59

The Pharma Data

MARCH 7, 2022

Decision Regarding Slick-Haired Cattle is Agency’s First Enforcement Discretion Decision for an Intentional Genomic Alteration in an Animal for Food Use. The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. Today, the U.S.

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Genome Genomics Production Marketing 52

Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

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The Pharma Data

JANUARY 10, 2021

11, 2021 (GLOBE NEWSWIRE) — Editas Medicine, Inc. Nasdaq: EDIT), a leading genome editing company, today announced the U.S. EDIT-301 is an experimental, ex vivo gene editing cell medicine in development for the treatment of sickle cell disease. Clinical trial materials are being manufactured by Editas Medicine.

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Medicine Development Clinical Trials Clinical Trials 52

Drug Discovery World

DECEMBER 15, 2022

Gene editing tools such as zinc finger nucleases, transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeat (CRISPR) nucleases have been heralded for their enormous potential to treat diseases and genetic disorders. Expand representation across global populations.

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Gene Editing Gene In-Vivo Genome 52

Drug Discovery World

JULY 3, 2023

The OXEGENE dataset contains anonymised genotype data including disease stage and infertility status, from 1,000 surgically confirmed patients. We hope that the analysis of our data will lead to the development of precision medicines to improve the lives of patients.”

Genetics 52

Genetics Genotype Medicine Licensing 52

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

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Genome Genomics Genetics Genome Project 102

The Pharma Data

JULY 15, 2021

The access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc. Nasdaq: BIIB) and Pfizer (NYSE: PFE).

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The Pharma Data

JULY 8, 2021

Today, access to the world’s largest browsable resource linking rare protein-coding genetic variants to human health and disease was launched through a genetic exome sequence analysis collaboration between AbbVie (NYSE: ABBV), Biogen Inc. Nasdaq: BIIB) and Pfizer (NYSE: PFE). The browser can be accessed via [link]. About AbbVie.

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Genetics Biobanking Protein Containment 52

Drug Discovery World

MARCH 21, 2023

Although this technique is broadly used, predicting its efficiency when aimed at certain points in the genome can be challenging, making it hard to reliably overexpress certain genes. For example, genes that contain H3K9me3 repressing regulators, and therefore are shielded from activation, showed greater variation in response.

Research 52

Research Gene Gene Editing Genome 52

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

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Genome Genomics Genetics Genome Project 80

Drug Discovery World

MARCH 7, 2023

Qatar’s pharmaceutical and healthcare markets, whilst receiving significant government attention, are still within their beginnings. As such, Qatar Biobank has emerged within this modernisation to act as a focal point for the country’s goal in preventive and personalised healthcare.

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Biobanking Drugs Genome Genomics 52

XTalks

DECEMBER 13, 2023

These efforts encompass programs related to the shingles vaccine, Tdap vaccine and plague vaccine, reinforcing Dynavax’s commitment to advancing the field of vaccines and medicine. The year 2022 has proven to be a momentous period for Fulgent Genetics, marked by significant expansion of its product portfolio across various medical conditions.

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Genetics Vaccination Vaccine DNA 111

Scienmag

AUGUST 13, 2020

Researchers from the Garvan Institute of Medical Research have uncovered four new subtypes of cells within triple negative breast cancer, which contain promising new therapeutic targets for the aggressive disease.

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Genome Genomics Containment Research 74

Pharmaceutical Technology

JUNE 14, 2023

However, more immeasurable characteristics such as personality, behaviour, and even intelligence are all influenced by genetics to varying degrees. metres of supercoiled DNA contained within its nucleus. All that DNA is organised into hereditary units called genes, with humans having about 25,000 genes collectively known as the genome.

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Genome Project Medicine Genome Genomics 130

Drug Discovery World

SEPTEMBER 14, 2023

Prognostic value and clinical significance of FGFR genomic alterations (GAs) in metastatic urothelial cancer patients. N Engl J Med 2019; 381(4):338-348. Fernandez E, et al. J Clin Med. 2022;11(15): 4483. Montazeri K & Bellmunt J. Erdafitinib for the treatment of metastatic bladder cancer.

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Containment Genetics FDA Approval Marketing 52

pharmaphorum

SEPTEMBER 14, 2020

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential.

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XTalks

JANUARY 2, 2024

Filsuvez topical gel is a sterile botanical drug product designed for topical use, containing birch triterpenes within an oil base. a biotech company specializing in the development and commercialization of genetic medicines for rare diseases, announced FDA approval for Vyjuvek for the treatment of DEB.

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The Pharma Data

DECEMBER 31, 2020

Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. The brain’s gray matter contains microglia and astrocytes. Rhesus Macaque Genome Reference Includes 85 Million Genetic Variants. Source link.

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Antibody Research Bacteria Genetics 52

Scienmag

JUNE 22, 2021

Chan […].

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Camargo

DECEMBER 10, 2021

In October 2017, the European Commission (EC) and the European Medicines Agency (EMA) collaborated with the Member States’ authorities to launch a plan to reduce discrepancies across the EU in applying certain legislation to advanced therapy medicinal products (ATMPs) containing or consisting of genetically modified organisms (GMOs).

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XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

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Research Biobanking Drugs Genome 98

Drug Discovery World

AUGUST 10, 2022

Cells from solid tumours are genetically heterogeneous both between and within tumours, making it challenging to identify a single, selective antigen target for treatment. If the gene does not integrate into the genome, the cell will not become a CAR T cell.

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Manufacturing Gene Genome Genomics 98

XTalks

APRIL 24, 2023

Approximately 72 percent of rare diseases are genetic, and around 70 percent of rare genetic diseases emerge in childhood. The European Medicines Agency (EMA) initially recommended six novel advanced therapy medicinal products (ATMPs) with orphan designation in 2022, but the orphan designation of one of these ATMPs was later withdrawn.

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Gene Therapy Gene Trials Clinical Trials 95

Drug Discovery World

MAY 17, 2024

Cancer trials are notorious because they are dependent on the genetic profile of patients and hence highly-selective. The researchers delved into the genetic makeup of tumours, recognising that genetic mutations heavily influence how tumours respond to drugs. National Human Genome Research Institute. UC San Diego Today.

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Trials Clinical Trials Clinical Trials Protein 59

FDA Law Blog

MAY 25, 2022

Javitt — On April 19, FDA issued a safety communication regarding genetic non-invasive prenatal screening, commonly referred to as non-invasive prenatal tests or NIPT ( here ). NIPT are intended to screen for genetic abnormalities in a fetus.

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The Pharma Data

NOVEMBER 3, 2020

Nasdaq:LOGC) (LogicBio), a company dedicated to extending the reach of genetic medicine with pioneering targeted delivery platforms, announced today the U.S. LogicBio Therapeutics is dedicated to extending the reach of genetic medicine with pioneering targeted delivery platforms. LEXINGTON, Mass.,

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Clinical Trials Clinical Trials Gene Editing Genome 52

Drug Discovery World

SEPTEMBER 5, 2022

Genome interpretation: To decipher genetic variants in cancer . The success of targeted therapies in cancer comes on the heels of identifying specific molecular targets resulting from genetic variations. When selecting patients for therapy, we currently look at variants that directly affect protein expression or function.

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Development Drugs Protein Genome 52

XTalks

AUGUST 20, 2020

The wearable device giant partnered with Scripps Research and Stanford Medicine to study the role of wearables to detect, track and contain infectious diseases like COVID-19 before the onset of symptoms. COVID-19 has presented a daunting challenge to medical researchers around the globe,” said Snyder in a press statement back in April.

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Medicine Research Development Genome 98

XTalks

OCTOBER 15, 2021

The lawsuit claims that Thermo Fisher is profiting off the stolen tissue samples, despite the broad publicity that Lacks’ story has received over the past decade and its link to a long tradition of discriminatory practices in medicine. Lacks and her family has been exposed to the general public.”.

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Drug Discovery World

MAY 11, 2023

First, products containing undesired proteases can impair drug stability, either by degrading the drug itself or by degrading stabilising excipients of the drug formulation, which ultimately diminishes the drug’s durability. These host cells alone contain over a thousand HCPs. coli, and Pichia cells. ” haematologica 107.4

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Production Gene Protein Vaccination 52

Drug Discovery World

NOVEMBER 15, 2022

The libraries contain only the sequences that occur in the human repertoire, rather than randomly generated sequences,” adds Dr Leproust. . They contain all the necessary enzymes for transcription and translation, making it possible to execute the central dogma outside a cell. . This approach has been around for a while.

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DNA Drugs Antibody Engineer 98

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutrigenomics is the science studying the relationship between human genome, nutrition and health. Similarly, people suffering from lactose intolerance must avoid milk products.

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The Pharma Data

NOVEMBER 24, 2020

. “Sadly, the risk of developing prostate cancer is significantly higher for carriers of the BRCA or ATM -gene mutation, which affects roughly 10 per cent of men living with mCRPC,” said Dr. Kim Chi, Medical Oncologist and Professor of Medicine at the University of British Columbia. ” . 3, 4, 5, 6 .

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XTalks

NOVEMBER 7, 2022

These tumor-derived entities are used to derive genomic and proteomic data. Dr. Bahassi explained that technological advances in genetic sequencing of cfDNA have enabled liquid biopsies and led to marked increase in the detection of therapeutically-targetable mutations. TruSight Oncology 500 ctDNA (Illumina; in-house solution).

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Clinical Trials Clinical Trials Trials FDA Approval 98

pharmaphorum

SEPTEMBER 18, 2020

In some positive news from the period, though, AstraZeneca, along with nine other biopharmaceutical companies, formed a non-profit organisation to accelerate the development of new medicines. While Gaithersburg was already home to MedImmune’s headquarters, it also became home to AZ’s US Global Medicines Development department.

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Pharma Marketing Network

JANUARY 20, 2021

In other areas of the industry (such as cell and genetic medicine development) progress continued at an impressively brisk pace despite the pandemic. When the patient is referred, a large historical data set (including biomarker and genetic data) will be available to the provider.

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