Development, DNA and Drugs - Clinical Research Informer

World’s largest catalogue of ocean DNA could boost drug discovery

Drug Discovery World

JANUARY 23, 2024

The world’s most comprehensive database for understanding microbial distribution and function in the ocean has been released, opening up new opportunities for drug discovery. ” The ability to collect and analyse such a new wealth of ocean data comes from major developments in DNA sequencing technology and computational power.

DNA

DNA Drugs Gene Scientist

Researchers teach AI to tailor artificial DNA for drug development

Drug Discovery World

NOVEMBER 29, 2022

Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . The technology can contribute to the development and production of vaccines and drugs for severe diseases much faster and at lower cost. .

DNA

DNA Development Research Drugs

Roche licenses drug to target cancer DNA damage response

Outsourcing Pharma

JULY 18, 2023

company KSQ Therapeutics to co-develop KSQâs lead cancer drug, which is designed to sabotage the DNA repair mechanisms of cancer cells. Roche has entered a licensing and collaboration deal with the U.S.

DNA

DNA Licensing Licensing Drugs

Unlocking the potential of synthetic DNA

Drug Discovery World

NOVEMBER 20, 2023

Raquel Sanches-Kuiper , Vice President of Science and Applications at Evonetix, and Clare Whitewoods , Marketing Communications Manager at Evonetix, look at the benefits synthetic DNA brings to pharmaceutical development. Their short development timeline gives mRNA vaccines several distinct advantages over traditional vaccines.

DNA

DNA Engineer Antibody Gene

Immuno-oncology collaboration to develop new type of cancer drug

Drug Discovery World

APRIL 19, 2023

Scientists at The Institute of Cancer Research, London, are teaming up with small molecule neoantigen immuno-oncology company NeoPhore to develop new potential cancer drugs. Image: Human breast cancer cells stained for DNA (red). New treatments aim to take advantage in cancer cells’ DNA repair mechanisms.

DNA

DNA Development Drugs Genome

2nd Mitochondria-Targeted Drug Development Summit

pharmaphorum

NOVEMBER 22, 2021

The 2nd annual Mitochondria-Targeted Drug Development Summit returns as the only industry-led meeting focused on overcoming the challenge of treating unmet medical needs caused by mitochondrial dysfunction. The Relationship of Mitochondrial DNA (mtDNA) Mutations/Damage & Mitochondrial Reactive Oxygen Species (ROS) Dysfunction.

Development

Development Drugs DNA Gene Therapy

Why Proviral DNA Drug Resistance Testing is Useful in Guiding Treatment Decisions for HIV-1 Patients

XTalks

APRIL 29, 2021

Sustained viral suppression is achieved through antiretroviral (ARV) therapy, which often consists of a cocktail of two or more ARV drugs that work to inhibit viral replication. HIV drug resistance has ben a problem since ARV drugs were first introduced in the late 1980s.

DNA

DNA Drugs RNA Genotype

Orbit and Evergreen partner to advance radiopharmaceuticals development

Pharmaceutical Technology

APRIL 4, 2023

Evergreen Discovery has partnered with Orbit Discovery to discover specific cell-targeting peptides and advance the development of new radiopharmaceuticals. The Orbit platform will also conduct in vitro transcription conversion from DNA-encoded libraries on beads.

Development

Development In-Vitro DNA Drugs

Exclusive roundtable on drug discovery and development trends

Drug Discovery World

JUNE 8, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development. Is it true that the next era will belong to antibody drug conjugates?

Development

Development Drugs Gene Therapy DNA

Artificial Intelligence innovation: Leading companies in in-silico drug discovery

Pharmaceutical Technology

FEBRUARY 23, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Artificial Intelligence in Pharmaceuticals: In-silico drug discovery. Adimab and Xencor are the other key patent filers of in-silico drug discovery.

Drugs

Drugs DNA In-Vivo In-Vitro

Webinar: Where are the breakthroughs in mRNA drug discovery and development?

Drug Discovery World

JUNE 21, 2023

Hosted by DDW and sponsored by Elegen, “Where are the breakthroughs in mRNA drug discovery and development?” Join this free webinar to learn about the opportunities in mRNA drug discovery and development. appeared first on Drug Discovery World (DDW). To secure your place, register for FREE now.

Development

Development Drugs DNA Engineer

Join our roundtable on drug discovery and development trends

Drug Discovery World

JUNE 15, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development. Is it true that the next era will belong to antibody drug conjugates?

Development

Development Drugs Gene Therapy DNA

2023 cancer research highlights: Drug development at its best

Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. As always, a year within cancer drug discovery and development brings with it significant breakthroughs, and 2023 has been no exception. Research into new cancer drugs remain strong.

Development

Development Research Drugs Antibody

Chemical ‘nose’ sniffs critical differences in DNA structures

Scienmag

MAY 3, 2021

Detection innovation could enhance drug development and cancer research Credit: Richard Hooley/UCR Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they’ve been extremely difficult to detect — until now.

DNA

DNA Development Drugs Research

GenScript ProBio and CCS partner for cell and gene therapies development

Pharmaceutical Technology

JUNE 8, 2023

GenScript ProBio has collaborated with the New York Blood Center Enterprises’ business unit, called Comprehensive Cell Solutions (CCS), to accelerate the development and manufacture of cell and gene therapies. The core objective of the collaboration is to make the therapies affordable and accessible to patients.

Gene Therapy

Gene Therapy Gene Development Antibody

Drug discovery and development trends – what will have most impact?

Drug Discovery World

JUNE 7, 2023

Hosted by DDW and sponsored by DNA Script, join us for this free-to-attend roundtable to learn about the biggest opportunities for the future of drug discovery and development. Is it true that the next era will belong to antibody drug conjugates? appeared first on Drug Discovery World (DDW).

Development

Development Gene Therapy Drugs DNA

Merck KGaA signs DNA damage response cancer deal with Artios Pharma

pharmaphorum

DECEMBER 3, 2020

Germany’s Merck KGaA has joined with UK-based Artios Pharma in a potential multi-billion dollar deal to investigate novel DNA damage response targets in cancer. The principle of DNA damage response is already being exploited by AstraZeneca and other companies with their poly (ADP-ribose) polymerase (PARP) inhibitor drugs.

DNA

DNA Genetics Research Sales

Junk DNA could lead to cancer, study says

Drug Discovery World

JULY 19, 2022

Non-coding or ‘junk’ DNA could contribute to the development of certain cancers due to how it disrupts the replication of the genome, scientists have discovered. . A team from The Institute of Cancer Research (ICR), London reconstituted the entire process of DNA replication in a test tube in order to understand it more completely.

DNA

DNA Genome Genomics Genetics

Junk DNA: How the dark genome is changing RNA therapies

Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. Many scientists are now discovering that this junk DNA plays an essential role in our biology and the epigenetic processes that respond to the environment to drive disease.

RNA

RNA Genome Genomics DNA

CatSci wins Welsh grant for innovative oligonucleotides development

Drug Discovery World

MARCH 5, 2024

The grant will enable the company to invest in new equipment that will increase the rapid creation of a large pool of candidates of RNA/DNA sequences. Production of oligonucleotides is currently both slow and expensive, meaning the development of new sequences tends to focus on producing small numbers of specific sequences only.

Development

Development RNA DNA Production

Ionis teams with Metagenomi and dives into gene editing

Bio Pharma Dive

NOVEMBER 14, 2022

The RNA drug developer is paying the richly-funded startup $80 million in a wide-ranging alliance that marks its first foray into DNA editing medicines.

Gene Editing

Gene Editing RNA DNA Gene

Touchlight completes expansion, creating one of the world’s largest DNA manufacturing facilities in London, UK

Drug Discovery Today

MAY 25, 2023

The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London.

DNA

DNA Manufacturing Genetics Medicine

FDA accepts GMP plasmid DMF: Andelyn now ‘on track’ to speed up gene therapy development

BioPharma Reporter

JANUARY 17, 2022

Andelyn Biosciences says the FDA's acceptance of its GMP plasmid DNA drug master file (DMF) enables the CDMO to vertically integrate its clientsâ manufacturing process, condensing timelines for developers to begin manufacturing to just three months.

Gene Therapy

Gene Therapy Development DNA Gene

Inovio’s INO-3107 receives orphan drug status from EC

Pharmaceutical Technology

MAY 24, 2023

Inovio has received orphan drug designation for INO-3107 from the European Commission (EC) to treat recurrent respiratory papillomatosis (RRP). In July 2020, the US Food and Drug Administration (FDA) also granted orphan drug designation to INO-3107.

Drugs

Drugs DNA Medicine Regulation

Study reveals how stomach cancers develop drug resistance

Drug Discovery World

OCTOBER 25, 2022

Scientists have shown how stomach cancers can develop resistance to a new class of drugs called ATR inhibitors by switching off the activity of two key genes – raising the possibility of outsmarting cancer by predicting drug resistance in advance. . Hope for new tests and treatments.

Development

Development Drugs Gene Editing Gene

Early phase support for plasmid DNA supply to secure future manufacturing

Drug Discovery World

NOVEMBER 23, 2022

One critical bottleneck in Cell and Gene Therapy (CGT) manufacturing is the production of high-quality plasmid DNA (pDNA), a vital building block for mRNA-based vaccines, viral vector-based cell or gene therapies that require pDNA as a starting material.

DNA

DNA Manufacturing Gene Therapy Gene

UCLA Jonsson Comprehensive Cancer Center study details chromosome-level changes that allow melanomas to develop drug resistance

Scienmag

DECEMBER 20, 2021

Precision therapies targeting melanoma and other cancers have improved patient survival, but tumors often stop responding to drugs, and recent studies point to changes in DNA – both inside and outside chromosomes – as a driving factor in tumor genesis as well as in treatment resistance.

DNA

DNA Drugs Development

The latest drug discovery product launches

Drug Discovery World

MAY 25, 2023

DNA Script: SYNTAX DNA printing platform Using the company’s EDS technology, the SYNTAX platform can synthesise up to 96 highly accurate, ready-to-use DNA oligos with maximum lengths of up to 120nt in less than 24 hours in the laboratory. The platform works with the SYNTAX Hi-Fidelity reagent kits for synthesising longer oligos.

Production

Production Reagent DNA Drugs

Webinar: The breakthroughs in mRNA drug discovery

Drug Discovery World

JULY 12, 2023

Hosted by DDW and sponsored by Elegen, “Where are the breakthroughs in mRNA drug discovery and development?” Join this free webinar to learn about the opportunities in mRNA drug discovery and development. will be free to attend on July 19 at 8AM PDT / 11AM EST / 4PM BST / 5PM CET.

Drugs

Drugs DNA Development Engineer

UNH team finds repurposed drug hinders enzyme activity linked to Covid-19

Pharmaceutical Technology

JUNE 23, 2022

Researchers at the University of New Hampshire (UNH) have found that a repurposed drug, CCG-50014, could hinder the activity of a key enzyme of the SARS-CoV-2 virus, which causes Covid-19. Utilising a currently available drug compound in a new way is called drug repurposing.

Drugs

Drugs Protein Genome Genomics

Learn about the opportunities in mRNA drug discovery

Drug Discovery World

JUNE 28, 2023

Hosted by DDW and sponsored by Elegen, “Where are the breakthroughs in mRNA drug discovery and development?” Join this free webinar to learn about the opportunities in mRNA drug discovery and development. will be free to attend on July 19 at 8AM PDT / 11AM EST / 4PM BST / 5PM CET.

Drugs

Drugs DNA Development Engineer

STAT+: After blazing trails in RNA-targeted drugs, Ionis jumps into gene editing

STAT News

NOVEMBER 14, 2022

Ionis Pharmaceuticals, the California company that turned RNA-targeting medicines from an unproven idea into blockbuster drugs, is now expanding into a new class of therapeutics that treat disease by editing DNA. On Monday, the company announced a partnership with Metagenomi to kickstart these efforts.

Gene Editing

Gene Editing RNA Gene Drugs

$4.3 million awarded to advance transcription factor drugs

Drug Discovery World

AUGUST 21, 2023

SBIR fast-track grant from the NIH to apply its proprietary Multiplexed Assays for the Rational Modulation Of Transcription Factors (MARMOT) platform to their deep learning AI model and accelerate the development of transcription factor drugs. Talus Bio was also awarded a $2.0M The post $4.3

Drugs

Drugs Gene Expression Protein Gene

This week in drug discovery (4-8 December)

Drug Discovery World

DECEMBER 8, 2023

The news highlights this week are mostly focused around neuroscience, with new guiding principles and a drug repurposing fund launched for motor neuron disease research, a new drug target found for early-onset dementia, and a possibly game-changing schizophrenia drug entering human trials.

Drugs

Drugs DNA Clinical Trials Clinical Trials

GenScript ProBio and RVAC partner for Covid-19 vaccine pDNA

Pharmaceutical Technology

FEBRUARY 23, 2023

GenScript ProBio has announced a strategic collaboration with RVAC Medicines to manufacture GMP-grade plasmid DNA (pDNA) for the latter’s RVM-V001, an mRNA Covid-19 vaccine candidate. The company provides end-to-end contract development and manufacturing organisation (CDMO) services from the discovery to the commercialisation of drugs.

Vaccination

Vaccination Vaccine Gene Therapy Manufacturing

Epigenetics vital in predicting cancer drug outcomes

Drug Discovery World

OCTOBER 27, 2022

Cancers can evolve to become more aggressive without relying only on DNA mutations, two major studies have revealed. . The two studies showed how a level of gene control called ‘epigenetics’ plays a central role in the development and progression of bowel cancer. The research .

DNA

DNA Drugs Gene Genetics

A new hub for developing medicines of the future at the University of Gothenburg

Scienmag

MARCH 1, 2021

Credit: Johan Wingborg In recent years, techniques have been developed to treat diseases with what are known as oligonucleotide drugs, based on short DNA or RNA molecules.

Medicine

Medicine Development RNA DNA

Verge Genomics takes AI-sourced drug for ALS into clinic

pharmaphorum

OCTOBER 31, 2022

Verge Genomics has joined a select group of biotechs who have taken a drug discovered and developed using artificial intelligence into human testing. Since then others have followed suit, including BenevolentAI with its BEN-2293 candidate for atopic dermatitis and Insilico Medicine with idiopathic pulmonary fibrosis therapy SM001-055.

Genome

Genome Genomics Drugs RNA

TPD Assay Development & Screening Summit

pharmaphorum

OCTOBER 7, 2022

With new technologies such as CryoEM and DNA encoded libraries showing promise, join us as we take a deep dive into the key challenges holding back the progression of candidates into pre-clinical studies by determining the best technologies and methodologies for your programs. View the full event guide here.

Development

Development DNA Protein Drugs

Leading innovators in periodontitis drugs for the pharmaceutical industry

Pharmaceutical Technology

MAY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Periodontitis drugs. However, not all innovations are equal and nor do they follow a constant upward trend.

Drugs

Drugs Vaccination Vaccine Antibody

IoT innovation: Leading companies in nanoparticles for drug delivery

Pharmaceutical Technology

FEBRUARY 14, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Key innovation: Leading companies in nanoparticles for drug delivery. Bristol-Myers Squibb is the leading patent filer in nanoparticles for drug delivery.

Drug Delivery

Drug Delivery Drugs Drug Delivery Systems FDA Approval

Innovation in chemotherapy: Leading companies in platinum-based cancer drug compositions

Pharmaceutical Technology

MARCH 14, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Platinum-based cancer drug compositions. Several platinum-based drugs such as cisplatin, carboplatin and oxaliplatin are widely used in cancer therapy.

Drugs

Drugs DNA Genetics Development

Leading innovators in oxazole derivatives-based cancer drug compositions

Pharmaceutical Technology

MAY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Oxazole derivatives-based cancer drug compositions. However, not all innovations are equal and nor do they follow a constant upward trend.

Drugs

Drugs DNA Protein Antibody

Join this exclusive DDW roundtable on drug discovery trends

Drug Discovery World

JUNE 27, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Join this free roundtable to learn about the biggest opportunities for the future of drug discovery and development. Is it true that the next era will belong to antibody drug conjugates?

Drugs

Drugs Gene Therapy DNA Antibody

World’s largest catalogue of ocean DNA could boost drug discovery

Researchers teach AI to tailor artificial DNA for drug development

Trending Sources

Roche licenses drug to target cancer DNA damage response

Unlocking the potential of synthetic DNA

Immuno-oncology collaboration to develop new type of cancer drug

2nd Mitochondria-Targeted Drug Development Summit

Why Proviral DNA Drug Resistance Testing is Useful in Guiding Treatment Decisions for HIV-1 Patients

Orbit and Evergreen partner to advance radiopharmaceuticals development

Exclusive roundtable on drug discovery and development trends

Artificial Intelligence innovation: Leading companies in in-silico drug discovery

Webinar: Where are the breakthroughs in mRNA drug discovery and development?

Join our roundtable on drug discovery and development trends

2023 cancer research highlights: Drug development at its best

Chemical ‘nose’ sniffs critical differences in DNA structures

GenScript ProBio and CCS partner for cell and gene therapies development

Drug discovery and development trends – what will have most impact?

Merck KGaA signs DNA damage response cancer deal with Artios Pharma

Junk DNA could lead to cancer, study says

Junk DNA: How the dark genome is changing RNA therapies

CatSci wins Welsh grant for innovative oligonucleotides development

Ionis teams with Metagenomi and dives into gene editing

Touchlight completes expansion, creating one of the world’s largest DNA manufacturing facilities in London, UK

FDA accepts GMP plasmid DMF: Andelyn now ‘on track’ to speed up gene therapy development

Inovio’s INO-3107 receives orphan drug status from EC

Study reveals how stomach cancers develop drug resistance

Early phase support for plasmid DNA supply to secure future manufacturing

UCLA Jonsson Comprehensive Cancer Center study details chromosome-level changes that allow melanomas to develop drug resistance

The latest drug discovery product launches

Webinar: The breakthroughs in mRNA drug discovery

UNH team finds repurposed drug hinders enzyme activity linked to Covid-19

Learn about the opportunities in mRNA drug discovery

STAT+: After blazing trails in RNA-targeted drugs, Ionis jumps into gene editing

$4.3 million awarded to advance transcription factor drugs

This week in drug discovery (4-8 December)

GenScript ProBio and RVAC partner for Covid-19 vaccine pDNA

Epigenetics vital in predicting cancer drug outcomes

A new hub for developing medicines of the future at the University of Gothenburg

Verge Genomics takes AI-sourced drug for ALS into clinic

TPD Assay Development & Screening Summit

Leading innovators in periodontitis drugs for the pharmaceutical industry

IoT innovation: Leading companies in nanoparticles for drug delivery

Innovation in chemotherapy: Leading companies in platinum-based cancer drug compositions

Leading innovators in oxazole derivatives-based cancer drug compositions

Join this exclusive DDW roundtable on drug discovery trends

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