Pharmaceutical Technology

MARCH 2, 2023

QN-023a is under clinical development by Hangzhou Qihan Biotechnology and currently in Phase I for Relapsed Acute Myeloid Leukemia. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data.

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Gene Editing Genetic Engineering Engineer Clinical Trials 100

STAT News

JULY 11, 2022

Then it was almost instantly derailed by the death of an 18-year-old clinical trial volunteer named Jesse Gelsinger after he received a genetically engineered virus that had been developed to treat his rare liver condition.

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Gene Gene Therapy Genetic Engineering Engineer 111

Pharmaceutical Technology

APRIL 26, 2023

This marks the first-ever designation for genetically modified gamma-delta T cell therapies. INB-400, an autologous, genetically engineered gamma-delta T cell therapy, is the company’s DeltEx chemotherapy-resistant autologous and allogeneic drug-resistant immunotherapy (DRI) technology.

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Genetic Engineering Drugs Genetics Engineer 130

pharmaphorum

MARCH 2, 2021

A combination of urgent need, unprecedented investments, and advances in genetic engineering has allowed what was once mere speculation to become not only our reality, but our future. Define clinically meaningful endpoints to successfully develop and safely deliver optimal doses for public use.

Genetics 52

Genetics Vaccination Vaccine Development 52

BioPharma Reporter

SEPTEMBER 1, 2022

RoosterBio has entered into an exclusive distributor partnership with MBL Beijing Biotech: with RoosterBioâs expansion media, exosome collection media, bioreactor media and genetic engineering media to be sold and distributed by MBL Beijing and thus becoming readily accessible for the first time to MSC and exosome therapy developers in China.

Genetic Engineering 52

Genetic Engineering Manufacturing Engineer Genetics 52

Drug Discovery World

MARCH 21, 2023

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. Genetic engineering The findings build on earlier efforts by genetic engineers, which involved genetically reprogramming E.

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Engineer Genetic Engineering Scientist Bacteria 52

Pharmaceutical Technology

AUGUST 17, 2022

Biopharmaceutical contract development and manufacturing organisation (CDMO) AGC Biologics has entered a strategic collaboration with RoosterBio to expedite the manufacturing of cell and exosome therapies. These capabilities comprise cell and exosome genetic engineering for expressing therapeutic targets.

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Manufacturing Gene Therapy Genetic Engineering Gene 130

Scienmag

JUNE 27, 2021

Credit: McMaster University HAMILTON, ON June 28, 2021 — Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

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Engineer Genetic Engineering Research Genetics 61

Scienmag

DECEMBER 30, 2021

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient’s own immune cells to fight cancer. Now, scientists at Memorial Sloan Kettering Cancer Center’s Sloan Kettering Institute (SKI) have developed new CAR T cells that can do something their […].

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Scientist Genetic Engineering Engineer Genetics 61

pharmaphorum

DECEMBER 24, 2020

Tian’s lab builds on the work of scientists in the lab of Dr Loren Looger, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, Virginia, who used traditional genetic engineering techniques to convert the bacterial protein into a sensor of the neurotransmitter acetylcholine.

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Development Drugs Protein Genetic Engineering 75

XTalks

MARCH 21, 2024

In this episode of the Xtalks Food Podcast, Sydney talks about the new offerings, which were developed in collaboration with NotCo, a Chilean food-tech firm renowned for its AI-driven approach to crafting plant-based food solutions. The products contain ingredients like bamboo fiber, pea protein and mushrooms.

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Genetic Engineering Production Engineer Containment 98

Scienmag

MARCH 5, 2021

Researchers develop tunable system that harnesses the spread of cargo carried by gene drives Credit: Gerard Terradas, UC San Diego Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

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Gene Scientist Genetic Engineering Genetics 52

Scienmag

SEPTEMBER 8, 2020

Credit: Avalos Lab/Princeton University Researchers at Princeton University have created a new and improved way to more precisely control genetically engineered bacteria: by simply switching the lights on and off. Working in E.

Bacteria 56

Bacteria Genetic Engineering Engineer Genetics 56

Pharmaceutical Technology

FEBRUARY 15, 2023

To obtain human antibody responses within a mouse, mice are genetically engineered to be humanised for their Ig genes. KO-plus-transgenic humanisation involves generating genetically engineered (HumAb) mice by disrupting the endogenous mouse Ig genes and simultaneously introducing human Ig transgenes at a different and random location.

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Gene Expression Gene Genetic Engineering Antibody 130

Scienmag

APRIL 27, 2021

April 27, 2021 — University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease. First-of-its-kind advance holds promise for making new strides in research, treatments Irvine, Calif.,

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Genetic Engineering Genetics Engineer Development 51

BioTech 365

JULY 26, 2021

ERS Genomics and Japan SLC Sign CRISPR/Cas9 License Agreement ERS Genomics and Japan SLC Sign CRISPR/Cas9 License Agreement Nobel prize winning CRISPR technology to be applied in development of genetically engineered animal models DUBLIN & SHIZUOKA, Japan–(BUSINESS WIRE)–ERS Genomics Limited, … Continue reading →

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Genome Genomics Licensing Licensing 52

BioTech 365

MARCH 9, 2021

ERS Genomics and Setsuro Tech Sign CRISPR/Cas9 License Agreement ERS Genomics and Setsuro Tech Sign CRISPR/Cas9 License Agreement Nobel prize winning CRISPR technology to be applied in development of genetically engineered cell and animal models DUBLIN & TOKUSHIMA, Japan–(BUSINESS WIRE)–ERS … Continue reading →

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Genome Genomics Licensing Licensing 52

Pharmaceutical Technology

JUNE 29, 2022

Developing best-in-class speciality enzymes. Novozymes has a long legacy of enzyme discovery and the ability to genetically engineer these speciality enzymes to be superior. After joint development, screening, and proof of concept, we purify the selected enzyme intermediate from Novozymes under cGMP conditions.

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Drugs Gene Therapy Manufacturing Production 295

Drug Discovery World

OCTOBER 26, 2022

An international team of scientists have engineered protein banana lectin, or BanLec, to create a new version that can fight off a range of viruses without unwanted side effects. . Tamiflu is only modestly effective, especially in critically ill patients, and influenza can develop resistance to it.

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Engineer Genetic Engineering Scientist Protein 52

Pharmaceutical Technology

MAY 2, 2023

Chimeric antigen receptor T-cell (CAR-T) therapies are the only genetically modified cell therapies to have received regulatory approval, and they are currently utilised in relapsed/refractory settings. Cost-related unmet needs also scored highly.

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Genetic Engineering Antibody Clinical Trials Clinical Trials 130

XTalks

SEPTEMBER 27, 2023

Poseida is a clinical-stage biopharmaceutical firm that utilizes its unique non-viral gene engineering methods to develop innovative cell and gene therapies. She brings a wealth of knowledge from the biopharmaceutical realm, with expertise in oncology and allogeneic T-cell immunotherapy.

Life Science 59

Life Science Genetic Engineering Engineer Gene Therapy 59

XTalks

MARCH 18, 2024

The precision fermentation study highlights how genetically engineered microorganisms can inhibit the growth of foodborne pathogens. Words like “bioengineered” and “genetically modified” often provoke negative reactions. This not only extends the shelf life of foods but also ensures they are safer for consumption.

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Genetic Engineering Genetics Production Protein 52

Drug Discovery World

NOVEMBER 27, 2023

Across the biotherapeutics workflow The landscape of large molecule drug development has evolved significantly in recent decades. Technological innovations supporting discovery and development stages have concentrated on both upstream and downstream aspects of the workflow. This article is sponsored by Revvity.

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Production Engineer Gene Editing Gene 59

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today provided an update on its COVID-19 vaccine program. Statements herein relating to the future of Novavax and the ongoing development of its vaccine and adjuvant products are forward-looking statements.

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Clinical Development Vaccination Vaccine Development 52

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials.

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Engineer Genetics Clinical Research Research 52

Drug Discovery World

OCTOBER 4, 2022

With winter around the corner and cases once again on the rise, the last few weeks have seen some interesting developments related to Covid-19. A new study has provided the first detailed genetic insights into the pathophysiological mechanisms underpinning Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). .

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Genetic Engineering Genetics Engineer Drugs 52

Roots Analysis

FEBRUARY 26, 2024

Over the next few decades, the identification of various pathogenic strains of microorganisms validated Koch’s assumptions and led to the development of more specific forms of therapy. Despite the widespread success of such interventions, certain limitations and drawbacks necessitated further research to develop better alternatives.

Genetics 52

Genetics Medicine Genetic Engineering Genetic Disease 52

pharmaphorum

MAY 7, 2021

Gene editing firm CRISPR Therapeutics has announced a collaboration with US biotech Nkarta to develop natural killer (NK) cell therapies for cancer. Under the agreement, the companies will co-develop and co-market two CAR NK cell product candidates, one targeting the CD70 tumour antigen and the other target to be determined.

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Gene Editing Gene Genetic Engineering DNA 52

pharmaphorum

SEPTEMBER 11, 2022

With the results in hand, the developers of the therapy – from the Netherlands Cancer Institute and Norway’s National Center for Cancer Immune Therapy – say they now intend to file for regulatory approvals in Europe before the end of the year, without a commercial partner “to try to ensure that it remains affordable.”

Trials 104

Trials Genetic Engineering Immune Response Engineer 104

Bioengineer

JULY 21, 2021

Researchers have proposed a new scoring system for wound healing in mice based on parameters in each phase of healing, as described in an article in the peer-reviewed journal Stem Cells and Development. Mari van de Vyver, from Stellenbosch University, and colleagues developed this histology scoring system for murine cutaneous wounds.

Genetic Engineering 52

Genetic Engineering Development Engineer Genetics 52

Pharmaceutical Technology

MAY 8, 2023

Innovation S-curve for the pharmaceutical industry Zinc-finger nucleases is a key innovation area in pharmaceutical Zinc finger nucleases (ZFNs) are tools used in genetic engineering to cleave a chosen genomic sequence. The company’s R&D is also focused on drugs for central nervous system, infections and genetic disorders.

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Genetics DNA Genetic Engineering Antibody 130

Drug Discovery World

FEBRUARY 14, 2024

Especially for rapidly-mutating viruses (such as SARS-CoV-2), tools that can help inform the rapid development of vaccines are crucial in being better prepared for future health crises. Unlike other types of vaccines that use viral genetic codes or viral vectors, recombinant protein vaccines use only the antigenic proteins themselves.

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Protein Vaccination Vaccine Manufacturing 59

Bioengineer

JULY 19, 2021

The development of KRAS inhibitors is, thus, an extremely active line of research. ” KRAS genes in embryonic development. The researchers at the CNIO created two genetically engineered mouse models that lacked KRAS4B and expressed the KRAS4A variant only, both with and without the G12V mutation (KRAS4AG12V).

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Research Gene Genetic Engineering Genetics 52

The Pharma Data

JANUARY 17, 2021

These models are engrafted with mouse tumors derived from the same strain background; this genetic similarity between tumor and host prevents the host from rejecting the tumor. Standard mice may develop anti-drug antibodies (ADA), which can neutralize the therapeutic or even trigger anaphylaxis.

Genetic Engineering 52

Genetic Engineering Genetics Engineer Immune Response 52

pharmaphorum

FEBRUARY 18, 2021

Researchers from the University of Texas Medical Branch based their findings on lab tests using SARS-CoV-2 coronaviruses that were genetically engineered to have the same mutations as those in the strain that is causing scientists so much concern.

Immune Response 52

Immune Response Genetic Engineering Vaccination Vaccine 52

Pharmaceutical Technology

APRIL 5, 2023

This includes the first potential approval of a CRISPR-based gene therapy called exa-cel , which is developed by CRISPR Therapeutics and Vertex Pharmaceuticals. It’s a multifaceted issue and we perhaps need to go beyond our comfort zone in science and clinical development to understand what barriers patients are really facing.

Gene Therapy 147

Gene Therapy Gene Engineer Production 147

Drug Discovery World

MAY 7, 2024

Ultimately, we owe it to patients to work together and come up with new and innovative manufacturing as well as process development approaches to accelerate the development and achieve speed to clinic. RA: In recent years, what improvements have we seen to cell-line engineering for antibodies?

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Antibody Production Manufacturing Engineer 59