Researchers speed identification of DNA regions that regulate gene expression

Scienmag

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Biology Gene Therapy Genes Genetics Medicine/Health

Early-life social connections influence gene expression, stress resilience

Scienmag

Strong social connections and greater maternal care early in life can influence molecular markers related to gene expression in DNA and future stress response, suggests a […]. Credit: Kay E.

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Gene expression altered by direction of forces acting on cell

Scienmag

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. CHAMPAIGN, Ill. — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.

Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & Reagents), Technique (Promoter Analysis, RNA Exp.) – ResearchAndMarkets.com

BioTech 365

Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & Reagents), Technique (Promoter Analysis, RNA Exp.) – ResearchAndMarkets.com Global Gene Expression Market Size, Share & Trends Analysis 2021-2028 by Product (DNA Chip/Microarray, Kits & … Continue reading → Business Wire

#news #biotech New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue reading → #news

#news #biotech MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without changing DNA

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without changing DNA.MIT and UCSF researchers create CRISPR ‘on-off switch’ that controls gene expression without … Continue reading → #news

Novel artificial genomic DNA can replicate and evolve outside the cell

Scienmag

Biology Artificial cell DNA evolve genomic replicate

DNA 83

Key early steps in gene expression captured in real time by CSU researchers

Scienmag

Cellular proteins get their marching orders from genetic instructions encoded in DNA, whose sequences are first copied and made […]. Capturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function. Chemistry AND Physics Biochemistry Bioinformatics Biology Biomechanics/Biophysics Genetics

#news #biotech GTEx Consortium releases fresh insights into how DNA differences govern gene expression

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from … Continue reading → #news

Epigenetic Therapeutic Targets Summit

Pharma Phorum

Join the Epigenetic Therapeutic Targets Summit – the only virtual summit dedicated to the clinical translation and optimization of therapeutic candidates targeting epigenetic mechanisms of gene expression.

Tune Therapeutics Debuts with $40 Million to Fine-Tune the Human Genome

BioSpace

Tune claims TEMPO can rapidly target and adjust the epigenomic machinery, controlling gene expression and dictating how the DNA will be molded

Anti-convulsant drug can modify DNA conformation and interact with chromosome proteins

Scienmag

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of […].

Solving ancient problem of nucleic acid synthesis helps to design new antiviral drugs

Scienmag

An international team of scientists from the University of Turku, Finland and PennState University, USA have solved a long-standing mystery of how living organisms distinguish RNA and DNA building blocks during gene expression paving the way for the design of new antiviral drugs.

Biomarkers in fathers’ sperm linked to offspring autism

Scienmag

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. PULLMAN, Wash. – Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder.

“Nuclear speckle” structures inside cells enhance gene activity, may help block cancers

Scienmag

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in partnership with a key […]. Cancer Biology cancer Cell Biology Genes Genetics

Gene Therapy and Pharmacokinetics

Camargo

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19.

Epigenetic Editing with CRISPR Might Be Easier Than We Thought

XTalks

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself.

DNA 83

Epigenetic Editing with CRISPR + ADHD in Preschoolers – Xtalks Life Science Podcast Ep. 10

XTalks

In this episode, Ayesha discusses a new tool that uses CRISPR to modulate gene expression without editing DNA sequences. Blogs Life Science Blogs Life Science Podcast CRISPR Gene Editing Pediatrics ADHD Epigenetic Editing

Using CRISPR to Edit the Epigenome Might Be Easier Than We Thought

XTalks

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. It’s a great tool for controlling gene expression.”.

DNA 52

Women in Science Who Have Paved the Way Forward in Genetics

XTalks

Geneticist Martha Chase was a key partner of the foundational Hershey-Chase experiment that helped confirm DNA to be the carrier of genetic information; however, it was only Hershey of the pair that went on to win the Nobel Prize in Physiology or Medicine in 1969 for the discovery.

Symvivo’s Oral COVID-19 Vaccine Enters Clinical Trials

XTalks

The Burnaby, BC-based company developed the oral DNA-based vaccine using its proprietary bacTRL Gene Therapy Platform, which uses genetically modified bifidobacteria as carriers of genetic vaccine elements on a DNA plasmid. The gene therapy-based vaccine targets mucosal tissues in the gastrointestinal tract, allowing for greater selectivity and targeted delivery compared to traditional vaccines. BacTRL Gene Therapy Platform.

bluebird seeks gene therapy trial restart after cancer scare

Pharma Phorum

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy.

Zynteglo halt re-ignites viral vector safety concerns; analysts

Pharma Phorum

Bluebird Bio’s decision to hit pause on the launch of Zynteglo for beta thalassaemia after two cases of cancer were seen in a clinical trial could see fears over the safety of viral vectors used to deliver gene therapies resurface. .

Roche-UCB’s $120M collaboration; Omega snags $85M; ExeVir raises $27M; GSK culls pipeline meds after failures

Delveinsight

Omega’s platform is designed to adjust gene expression to healthy levels rather than switching genes on and off. The work of the company is based on the genes and their regulatory elements found in loops of DNA called Insulated Genomic Domains (IGDs).

Gene editing: beyond the hype

Pharma Phorum

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome.

Clinical Catch-Up: December 21-25 | BioSpace

The Pharma Data

STP705 is a small interfering RNA (siRNA) therapy that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to knock down both TGF-beta1 and COX-2 gene expression.

Angle PLC Announces Submission Accepted by FDA for Substantive Review

The Pharma Data

CTCs enable the complete picture of a cancer to be seen, as, being an intact cell, they allow DNA, RNA and protein analysis and thus provide comparable analysis to a tissue biopsy. The HyCEAD Ziplex system is extremely sensitive and is ideal for measuring gene expression and other markers directly from Parsortix harvests and was used in the ovarian cancer pelvic mass triage test to achieve best in class accuracy (AUC-ROC) of 95.1%.

What the Glycome Can Tell Us About Persistent HIV Infection

XTalks

This interaction allows cancer cells to evade immune surveillance as Siglecs are expressed by many immune cells including NK cells. It was observed that active HIV transcription, but not cellular activation, induces SLe X cell-surface expression in vitro.

RNA 52

2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences

XTalks

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic.