Mon.Jan 31, 2022

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Roche wins FDA approval for rival to Regeneron's lucrative eye drug

Bio Pharma Dive

The drug, which will be sold as Vabysmo, is the first of several emerging competitive threats to Regeneron's top-selling Eylea, along with biosimilars and long-acting implants.

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New diagnostic finds hidden lung damage in long COVID

pharmaphorum

People with long-lasting symptoms of breathlessness after COVID-19 infection may have damage to their lungs that does not show up using routine diagnostic scans, according to a small UK study. The researchers from Oxford, Sheffield, Cardiff and Manchester universities used a new form of diagnostic that involves patients breathing in the inert gas xenon whilst undergoing an MRI scan, which allows them to gauge how well gases like oxygen are being transferred from the lungs to blood vessels.

Research 108
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Pfizer stops development of once-promising heart drug, handing back rights to partner Ionis

Bio Pharma Dive

Pfizer concluded the data didn't support advancing the ANGPTL3-targeting drug — for which it paid $250 million two years ago to acquire the rights — despite positive study results.

Drugs 280
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Biogen promises increased diversity in Phase 4 Aduhelm trial

BioPharma Reporter

Biogen releases further details on how its Phase 4 post-marketing confirmatory study for Alzheimerâs drug, Aduhelm, will run: including increased enrolment and enhanced efforts to encourage diversity.

Trials 105
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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Madrigal adds to safety data for NASH drug

Bio Pharma Dive

The biotech's drug is one of the few NASH treatments that has advanced to late-stage testing, as the disease has proven difficult for drugmakers to crack.

Drugs 288
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Plant-Based Lamb Producer Black Sheep Foods Raises $5.25 Million

XTalks

Black Sheep Foods, a plant-based food tech company focused on heritage breed meats and wild game, recently raised $5.25 million in seed funding led by Bessemer Venture Partners. This investment brings the company’s total seed funding to $5.5 million since its launch in 2019. So, how does Black Sheep Foods make its uncommon meat analogues and will it face competition in a heavily saturated market ?

More Trending

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UK research hub launched to tackle rare kidney disease

Outsourcing Pharma

The Stoneygate and Kidney Research UK Alport Research Hub aims to accelerate research and develop treatments for Alport syndrome, a rare genetic disorder.

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What the rise of oxygen on early Earth tells us about life on other planets

Scienmag

When did the Earth reach oxygen levels sufficient to support animal life? Researchers from McGill University have discovered that a rise in oxygen levels occurred in step with the evolution and expansion of complex, eukaryotic ecosystems. Their findings represent the strongest evidence to date that extremely low oxygen levels exerted an important limitation on evolution […].

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Digital innovation drives vaccine development

pharmaphorum

It is becoming increasingly important for people all over the world to understand the importance of vaccines and to have access to the vaccines they need – especially with digital innovation driving new vaccine development. Pfizer’s Josh Raysman, Saad Saeed, and Shanaya Deboo discuss vaccine awareness, access, and innovation. Access to and awareness of vaccines is more important than ever, especially in a globally connected world where outbreaks cannot easily be confined to a limited area.

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University of Kentucky awarded Beckman Scholars Program with undergraduate chemistry focus

Scienmag

LEXINGTON, Ky. (Jan. 31, 2022) — The University of Kentucky has been named a 2022 Beckman Scholars Program Award winner. The award will create a new program focusing on diversity and equity in undergraduate research — Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS). This prestigious, invite-only program for top-tier research institutions provides a […].

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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Daiichi makes play for share of Japan’s COVID booster market

pharmaphorum

Daiichi Sankyo has stepped up its efforts to bring a Japanese COVID-19 vaccine to patients, starting a new clinical trial of its mRNA-based candidate DS-5670 that focuses on its use as a booster dose. The Japanese group says it hopes to complete clinical development of the vaccine and bring it to market in Japan before the end of the year. Daiichi Sankyo started human testing of the shot in March 2021, with preliminary results in studies involving 142 healthy adults showing no safety concerns af

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Realizing warm white light-emitting with high efficient emission and high color rendering index by using ligand modified CsPbBr3 quantum dots

Scienmag

In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2022.200075 , the research group of Professor Zhigang Zang from Chongqing University, Chongqing, China discusses realizing warm white light-emitting with high efficient emission and high color rendering index by using ligand modified CsPbBr3 quantum dots. Credit: OEA In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2022.200075 , the research group of […].

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CHMP approves Dupixent for young children with asthma

Pharma Times

Positive news for children aged six to 11 as Dupixent offers improved asthma treatment

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Scientists uncover how the shape of melting ice depends on water temperature

Scienmag

A team of mathematicians and physicists has discovered how ice formations are shaped by external forces, such as water temperature. Its newly published research may offer another means for gauging factors that cause ice to melt. Credit: Courtesy of NYU’s Applied Mathematics Laboratory. A team of mathematicians and physicists has discovered how ice formations are […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Second COVID-19 antiviral set for release

Pharma Times

Vulnerable people at risk from COVID-19 are set to have access to game-changing Pfizer antiviral

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Ever wondered how many tree species live on our planet?

Scienmag

An Australian conservation scientist unafraid to go out on a limb – or crawl through thorny vines, or trek remote forests in storms – is among a group of global researchers who can now answer the question: How many tree species exist in the world? Credit: Photo credit: Ruben Mwakisoma An Australian conservation scientist unafraid […].

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Altimmune obesity drug candidate lands IND clearance from the FDA

Outsourcing Pharma

The pharma firm has announced the agency has approved the companyâs investigational new drug application for its Phase II trial of pemvidutide for obesity.

Drugs 68
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Precisely opening a gate to the brain in mice

Scienmag

University of Maryland School of Medicine researchers developed a technique in laboratory animals to consistently and reproducibly open the blood-brain barrier. This barrier serves as a barricade securing the brain from the external world blocking out certain environmental toxins, but also prevents drug therapies from reaching their intended targets.

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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What is a Data Base Lock?

ECRG Media's Clinical Research Podcast

What is Data Base Lock? Don't forget to Subscribe for new content! Merch: [link] Subscribe: [link] Email: eliteclinicalgroup@gmail.com Podcast: [link] Steemit: [link] Advertise: eliteclinicalgroup@gmail.com Watch: » Industry News: [link] » All Videos: [link] » Interview Recaps: [link] » Glassdoor Reviews: [link] We do: » Insider Interviews » Resume Reviews » Question and Answer » Discuss all things Clinical Research » News and Product Reviews » Education Send in a voice message: [link] What is D

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New study suggests an alternative technique for determining the true activity of catalysts

Scienmag

Electrolysis of water or “water electrosplitting” has received a great deal of attention recently owing to its potential as a clean source of hydrogen, the oft-touted fuel of the future. However, two issues have long stood in the way: the large amount of energy lost, and the cost of electrocatalysts (catalysts used for electrolysis). Fortunately, […].

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What is a Data Base Lock?

ECRG Media's Clinical Research Podcast

What is Data Base Lock? Don't forget to Subscribe for new content! Merch: [link] Subscribe: [link] Email: eliteclinicalgroup@gmail.com Podcast: [link] Steemit: [link] Advertise: eliteclinicalgroup@gmail.com Watch: » Industry News: [link] » All Videos: [link] » Interview Recaps: [link] » Glassdoor Reviews: [link] We do: » Insider Interviews » Resume Reviews » Question and Answer » Discuss all things Clinical Research » News and Product Reviews » Education.

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THE LANCET: Experts warn of the increasing overmedicalization of death, call for radical rethink of how society cares for dying people

Scienmag

Peer reviewed / Review and opinion Credit: The Lancet Peer reviewed / Review and opinion The COVID-19 pandemic has seen the ultimate medicalised death, with patients dying in intensive care with little communication with their families Technological and medical advances have fuelled the idea that science can defeat death, increasing the over-reliance on medical interventions, […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Glooko adds AI to its digital diabetes tools with xbird takeover

pharmaphorum

Glooko has made a name for itself in digital health circles with its data management tools for diabetes patients, and has now added artificial intelligence capabilities with an agreement to acquire xbird. The deal centres around Berlin, Germany-based xbird’s “just In time adaptive intervention” technologies – or JITAIs – which uses AI to analyse and categorise patient behaviour patterns based on mobile data inputs, and assess health risks.

Insulin 52
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A neuron that tracks landmarks helps rats know where they are

Scienmag

Visual landmarks enable an animal to know where it is oriented in relation to its environment. Dartmouth researchers have identified a new type of neuron in the rat brain, which appears to help facilitate this type of visual and spatial processing. The results are published in Science Advances. In the rat brain, neurons known as […].

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Digital health funding boom continues as ETAO cuts SPAC deal

pharmaphorum

Chinese digital health firm ETAO International will go public via a merger with a blank cheque company that will value it at around $2.5 billion. The deal with special purpose acquisition company (SPAC) Mountain Crest Acquisition Corp III (MCAE) will give the five-year-old telehealth group up to $304 million in gross proceeds, bolstered by a $250 million private round from China SME Investment Group.

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New ISS National Laboratory tool expands visibility of ISS-related educational resources

Scienmag

The Center for the Advancement of Science in Space, Inc. (CASIS), manager of the International Space Station (ISS) National Laboratory, today announced the release of a new online tool for educators called Expedition Space Lab. This tool is designed to provide educators with easy access to ISS-related lessons, activities, and other resources to integrate into […].

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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How can marketing teams and healthcare agencies partner up for modular content?

pharmaphorum

Creating personalised, compliant content is becoming increasingly important for life science companies as HCPs demand more from their digital content. Pharma companies created 3.5 times more digital content than print in 2020, driven by the growing prevalence of digital channels during the early stages of the Covid-19 pandemic. Yet, two years on, marketers still face mounting pressure to accelerate production and deliver greater volumes of content across multiple channels, often without the supp

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9,000 tree species yet to be discovered on Earth

Scienmag

Our planet might be hosting approximately 9,000 tree species yet to be discovered. A third of these are rare species with a population that is restricted both in terms of numbers and areas. This is one of the results of the first-ever estimate of tree species richness at the global level. Credit: Cazzolla Gatti et […].

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Pfizer sees no way forward for Ionis-partnered vupanorsen

pharmaphorum

Pfizer has called time on its alliance with Ionis for cholesterol-lowering therapy vupanorsen, after a review of phase 2b data raised some questions about the antisense drug’s efficacy and safety. It’s a setback to Pfizer’s late-stage pipeline, given that at one point the company was projecting $3 billion in potential sales for vupanorsen, which targets ANGPTL3 protein and is playing catch-up in the category with Regeneron’s already-marketed Evkeeza (evinacumab).

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Brain function boosted by daily physical activity in middle-aged, older adults

Scienmag

A new study by researchers at University of California San Diego School of Medicine adds to the canon of research associating physical activity with cognitive performance, this time using 90 middle-aged and older subjects who wore accelerometers while physically active and completed mobile cognitive testing from home. Credit: UC San Diego Health Sciences A new […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.