Sat.Sep 25, 2021 - Fri.Oct 01, 2021

After long wait, Editas reveals first data for CRISPR gene editing treatment

Bio Pharma Dive

Early study results offer some hopeful signs of efficacy, but the small number of patients treated and short follow-up limit firmer conclusions

Advancing from Research to Development: What Can Go Wrong?

Camargo

The drug development process is a long journey, beginning with drug discovery, moving through nonclinical and clinical studies, and ultimately culminating in regulatory approval.

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Quality of life in patients with chronic health conditions

World of DTC Marketing

SUMMARY : Six in ten Americans live with at least one chronic disease, like heart disease and stroke , cancer , or diabetes. These and other chronic diseases are the leading causes of death and disability in America, and they are also a top driver of health care costs.

TDP-43 DNA methylation may contribute to the mystery of age-dependent motor cortex involvement in ALS

Scienmag

Niigata, Japan – Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex.

DNA 91

Acceleron provides biggest biopharma deal this year, with $11.5B sale to Merck

Bio Pharma Dive

The acquisition is notable for Merck, which is under pressure to diversify its business beyond the cancer drug Keytruda and has typically favored smaller buyouts

Sales 266

Merck Says Its Antiviral Pill Is Effective Against Covid

NY Times

The drug maker will seek authorization for molnupiravir, the first drug of its kind for Covid. Experts said such pills could be a powerful tool against the virus.

What DTC marketers can learn from people who refuse vaccines

World of DTC Marketing

SUMMARY : Vaccine mandates are only going to get us so far when it comes to COVID immunity. The reasons for people refusing vaccines are both safety and side effect concerns, although politics plays a big part as well.

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Worrisome side effects lead Pfizer to narrow Duchenne gene therapy trial

Bio Pharma Dive

Outside trial data reviewers have attributed three cases of severe muscle weakness to Pfizer’s treatment, causing the company to change the design of its closely watched Phase 3 study

Incyte Names New Member to Its Board of Directors

BioTech 365

Incyte Names New Member to Its Board of Directors Incyte Names New Member to Its Board of Directors WILMINGTON, Del.–(BUSINESS –(BUSINESS WIRE)–$INCY–Incyte (Nasdaq:INCY) announces the appointment of Otis Brawley, M.D.,

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Amazon names 10 finalists in its first digital health accelerator

Pharma Phorum

Amazon’s push into healthcare takes many forms, and one is decidedly biotech-like – running an accelerator to identify and support startups with promising technology platforms.

Scientists use nuclear physics to probe Floridan Aquifer threatened by climate change

Scienmag

As rising sea levels threaten coastal areas, scientists are using an emerging nuclear dating technique to track the ins and outs of water flow Credit: (Image by Argonne National Laboratory.)

Merck says antiviral pill effective against COVID-19, lifting hopes for first oral drug

Bio Pharma Dive

The drugmaker, along with partner Ridgeback Biotherapeutics, plan to ask the FDA for emergency authorization "as soon as possible "

Drugs 255

BioNTech Doses First Patient with Personalized mRNA Cancer Vaccine

BioSpace

First COVID-19, now cancer. BioNTech made history when its COVID-19 mRNA vaccine with partner Pfizer became the first ever approved

Bayer teams up with Huma to apply AI to lung cancer diagnosis

Pharma Phorum

A research project between Bayer and digital health company Huma will use artificial intelligence to detect lung cancer in CT scans – and determine which type a patient has, in order to direct treatment.

Genome 104

Research in Brief: UNLV astronomers may have discovered first planet to orbit 3 stars

Scienmag

In a distant star system — a mere 1,300 light years away from Earth — UNLV researchers and colleagues may have identified the first known planet to orbit three stars. Credit: Credit: ALMA (ESO/NAOJ/NRAO), ESO/Exeter/Kraus et al.

5 FDA approval decisions to watch in the fourth quarter

Bio Pharma Dive

Regulators face key decisions on COVID-19 shots for children and boosters for Moderna's and J&J's vaccines. Other closely watched drugs for multiple myeloma and depression are under review, too

New report sheds light on medicine shortages in Northern Ireland following Brexit

Pharma Times

Informa Pharma Intelligence (IPI) has found that some drug firms may withdraw up to 90% of their products from Northern Ireland, once the Brexit grace period has passed

Barts Health NHS Trust launches app for cognitively impaired

Pharma Phorum

An app to support people with cognitive disabilities, developed with clinicians at Barts Health NHS Trust, has started to be made available more widely to patients.

Is your ML training set biased? How to develop new drugs based on merged datasets

Scienmag

CAMBRIDGE October 01 2021—Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions.

Eisai, Biogen to test FDA by asking for approval of second Alzheimer's drug

Bio Pharma Dive

The Japanese pharma and Biogen partner is filing an application for accelerated OK of lecanemab, which works similarly to the companies' controversially cleared Aduhelm

Drugs 226

How Has COVID-19 Changed the Way We Work in the Life Sciences?

XTalks

The world as we know it has changed because of the COVID-19 pandemic. We’ve adopted and embraced new technologies at a much faster pace in order to conform to these changes.

Treatment for all: the key steps to better representation in pharma

Pharma Phorum

As people have become more conscious and vocal about diversity and inclusion, Page & Page’s Lisa Lishman says pharma should reassess how it conducts clinical trials.

HR 99

Scientists discover 14 genes that cause obesity

Scienmag

Promising news in the effort to develop drugs to treat obesity: University of Virginia scientists have identified 14 genes that can cause and three that can prevent weight gain. The findings pave the way for treatments to combat a health problem that affects more than 40% of American adults.

Amicus, looking for a boost, sells its gene therapy work to a SPAC

Bio Pharma Dive

The value of the biotech's growing gene therapy portfolio has been "unrecognized" by investors, said CEO John Crowley, leading to a sudden shift for an initiative that began just three years ago

Gene Editing Breakthroughs Accelerate Heart, Stroke Research

BioSpace

?Gene therapy research delivers breakthroughs this week with a CRISPR-edited droplet that could lead to a cure for heart disease and the possibility of turning glial brain cells into neurons

Top email calamities to avoid … and how to make an impact instead

Pharma Phorum

Oliver Stohlmann’s Corporate Survival Hacks series draws on his experiences of working in local, regional and global life science communications to offer some little tips for enjoying a big business career.

Cancer patients on chemotherapy likely not fully protected by COVID-19 vaccine, study finds

Scienmag

The COVID-19 pandemic has been an especially stressful time for cancer patients undergoing chemotherapy, which attacks not only the cancer, but also the immune cells needed to defend the body from infections.

FDA lifts hold on GeneTx, Ultragenyx study of Angelman therapy

Bio Pharma Dive

The hold, which was put in place by the FDA during the fourth quarter last year, came after five patients in an early trial experienced muscle weakness following treatment

Trials 219

New Mexico health officials link misuse of ivermectin to two Covid-19 deaths.

NY Times

Calls to poison control centers have soared across the country as misinformation spreads touting the anti-parasite drug as a Covid treatment. Rumors and Misinformation Drugs (Pharmaceuticals) Poisoning and Poisons Coronavirus (2019-nCoV) Deaths (Fatalities) Oregon Mississippi New Mexico

Drugs 94

Takeda bags Japanese approval for Crohn’s cell therapy Alofisel

Pharma Phorum

Takeda has chalked up another milestone for its Alofisel cell therapy for a complication of Crohn’s disease, becoming the first allogeneic stem cell therapy to be approved in Japan.

Sales 97

PSMA PET imaging more accurate than CT in detecting hepatocellular carcinoma

Scienmag

Reston, VA (September 30, 2021)—PSMA (prostate-specific membrane antigen) PET/CT is more accurate than conventional CT in the detection of hepatocellular carcinoma metastases, according to research published in the September issue of The Journal of Nuclear Medicine.

GSK, Merck KGaA end cancer drug partnership after study results disappoint

Bio Pharma Dive

Bintrafusp alfa was highlighted by GSK as a potential blockbuster drug as recently as January. Negative findings in two trials, however, led the companies to unwind their research collaboration

Trials 207

Trio of Biopharmas Generates Over $500 Million for AI, Oncology Innovation

BioSpace

?This week, three global biopharmaceutical companies received over half a billion dollars to support research and development initiatives in the treatment of rare and deadly diseases

Merck confirms $11.5bn Acceleron takeover deal

Pharma Phorum

After days of speculation, Merck & Co confirmed today that it has agreed to acquire Acceleron Pharma $1.5 billion, setting up what could be one of the largest biopharma acquisitions of 2021 so far.

Early accumulation of tau in the brain predicts memory decline in Alzheimer’s disease

Scienmag

Researchers at Karolinska Institutet in Sweden have compared how well different Alzheimer’s biomarkers predict the progression of the disease and its effect on the memory.

Charged aerosol detection: Chromatographer's magical tool to unravel the invisible in biologics

Bio Pharma Dive

The discovery and development of next generation therapeutics will drive the availability and use of Biologics to meet the unmet medical needs, never imagined before

Editas Sees Light in First Data from In Vivo CRISPR Eye Therapy

BioSpace

EDIT-101 targets a disease-causing mutation in the CEP290 gene that causes degeneration in ocular photoreceptor cells, which are critical for normal vision