Sat.Jul 17, 2021 - Fri.Jul 23, 2021

Gene therapy for Fabry: early stages, promising results

Bio Pharma Dive

Three companies are testing their gene therapies in early clinical trials, with initial results due later this year. Others are in preclinical stages and aim to follow soon

Is pharma hiring the right people?

World of DTC Marketing

SUMMARY: Older, more experienced employees are being shoved aside in favor of more inexperienced ones. The culture within pharma is driving people away, including new hires. More and more meetings are based on ROI, not the voice of the patient.

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UTA researcher explores 3D printing of multilayered materials for smart helmets

Scienmag

A better helmet to protect soldiers in combat Credit: UT Arlington A mechanical and aerospace engineering professor at The University of Texas at Arlington is developing advanced helmets to ensure that members of the military are as protected as possible from blasts and other types of attacks.

Virtual reality therapy: The future of chronic pain management?

Pharma Phorum

Could virtual reality tools be effective in helping patients ‘unlearn’ their chronic pain? p harmaphorum speaks to Professor Christopher Eccleston from the University of Bath’s Centre of Pain Research to find out how digital therapeutics are shaping the future of pain management.

Caribou raises $304M in one of gene editing's most lucrative IPOs

Bio Pharma Dive

The IPO is several times larger than what CRISPR Therapeutics, Intellia and Editas raised several years ago, and ranks well ahead of a more recent offering from gene editing startup Beam

Is it time for vaccination mandates?

World of DTC Marketing

SUMMARY: 99 percent of covid-19 deaths in June were among the unvaccinated. 29 percent of Americans said they were unlikely to get vaccinated — up from 24 percent three months earlier.

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Preclinical Data on New Pancreatic Cancer Drug Shines with over 90% Efficacy

BioSpace

Preclinical data for its drug candidate, LP-184, reportedly showed over 90 percent efficacy in shrinking pancreatic cancer tumors in mouse models in vitro, in-vivo, and ex-vivo

A biotech's eye gene therapy faces longer odds as serious side effects pile up

Bio Pharma Dive

Five trial participants with diabetic macular edema who received Adverum Biotechnologies' treatment experienced side effects never before reported for an eye gene therapy

The debate on DTC marketing is going to heat up again

World of DTC Marketing

SUMMARY: DTC marketing is not the reason why prescription drugs cost so much. DTC ads raise awareness around health conditions. DTC ads do NOT lead to unnecessary Rxs. The FDA needs to study what people do when they see a DTC ad.

Sharks, lies, and videotape: Scientists document problems with Shark Week

Scienmag

Credit: Marion Kraschl, CC BY 3.0 link] via Wikimedia Commons MEADVILLE, PA – July 22, 2021 – Shark Week is many things. First and foremost, it’s a week of shark-themed documentary programming on the Discovery Channel.

Koselugo: The First Non-Surgical Alternative for Rare Plexiform Neurofibroma

BioSpace

Notably, Koselugo was studied in pediatric populations first, a reversal of the typical development path taken by the majority of drugs

Drugs 110

Bluebird, with little fanfare, is first to bring a second gene therapy to market

Bio Pharma Dive

The approval of Skysona for a genetic brain disease is a milestone for one of gene therapy's pioneering companies, but isn't expected to turn Bluebird's financial fortunes around

What DTC marketers can learn from people who refuse a COVID vaccination

World of DTC Marketing

SUMMARY: Even though the Delta variant of COVID is highly contagious, people are still choosing not to get vaccinated. Concerns about safety, fear of unknown side effects, and misinformation about COVID-19 are some reasons why people may not accept the vaccine.

Advantages of intranasal vaccination against SARS-CoV-2

Scienmag

Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract Credit: UAB BIRMINGHAM, Ala.

MSD, Bayer’s heart failure med Verquvo gains EU approval

Pharma Times

Verquvo cleared for the treatment of symptomatic chronic heart failure in patients with reduced ejection fraction

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BioNTech returns to cancer roots with deal for Gilead cell therapy factory

Bio Pharma Dive

The German biotech purchased Kite Pharma's Gaithersburg, Maryland-based site, along with related research on T cell receptor-based cancer treatments

Ten tips on pharma time management

Pharma Phorum

Oliver Stohlmann’s new Corporate Survival Hacks series draws on his experiences of working in local, regional and global life science communications to offer some little tips for enjoying a big business career. In this first instalment he tackles managing time.

New organ-on-a-chip finds crucial interaction between blood, ovarian cancer tumors

Scienmag

Team identifies crucial interaction between platelets and tumors for the first time Credit: Texas A&M Engineering In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body.

Weight Loss-Focused Gelesis Heads to NYSE via SPAC Deal, Other IPOs Filed

BioSpace

The Boston-based company merged with Capstar Special Purpose Acquisition Corp. and will begin trading on the New York Stock Exchange under the ticker symbol “GLS

97

J&J predicts faster coronavirus vaccine sales amid debate over boosters

Bio Pharma Dive

The pharmaceutical company expects $2.5 billion in sales from its shot this year, despite concerns over protection against variants and significant manufacturing setbacks

Sales 228

Pfizer puts up $1bn to buy into Arvinas breast cancer programme

Pharma Phorum

Pfizer has pledged a whopping $1 billion upfront for rights to an Arvinas drug for breast cancer from its protein degrader platform, which harnesses cells’ natural protein-denaturing machinery to remove rogue proteins associated with disease.

Using silicone wristbands to measure air quality

Scienmag

New plans to improve patient access to mental health services unveiled in England

Pharma Times

NHS England has set out new plans to introduce five new waiting time guarantees for mental health services

91

Ardelyx latest biotech surprised by unexpected FDA criticism of drug application

Bio Pharma Dive

The FDA cited problems with Ardelyx's case for its kidney disease drug just weeks before an approval deadline — feedback one analyst described as "troubling" evidence of FDA inconsistency

Drugs 224

GSK names McNamara as CEO of consumer health spinout

Pharma Phorum

GlaxoSmithKline has said that Brian McNamara – currently head of its three-year-old consumer health joint venture with Pfizer – will retain the top job at the business after it is hived off into a separate company next year.

Cascaded metasurfaces for dynamic control of THz wavefronts

Scienmag

Dynamic control of THz wavefronts demonstrated by rotating layers of cascaded metasurfaces Credit: Shanghai University Electromagnetic (EM) waves in the terahertz (THz) regime contribute to important applications in communications, security imaging, and bio- and chemical sensing.

NHS England unveils new Innovative Medicine Fund

Pharma Times

The new fund will build upon the Cancer Drugs Fund to fast-track access to promising new treatments

Amylyx, faced with longer FDA path for promising ALS drug, gets major cash infusion

Bio Pharma Dive

A $135 million investment will help the small biotech potentially prepare to launch the treatment in Canada and Europe as well as fund another trial requested by U.S. regulators

NuVasive Resumes Shipping of Spinal Implant, Continues to Address FDA Safety Warnings

XTalks

NuVasive , a medical device company focused on developing devices and procedures for minimally invasive spine surgery, has recommenced shipping of the newest version of its MAGEC line of spinal curve-correcting magnetic rod systems.

Comprehensive clinical sequencing opens door to the promise of precision medicine

Scienmag

Jude Children’s Research Hospital study highlights the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient’s cancer Credit: St. Jude Children’s Research Hospital St.

One Dose of J.&J. Vaccine Is Ineffective Against Delta, Study Suggests

NY Times

Many who received the shot may need to consider boosters, the authors said. But federal health officials do not recommend second doses.