pharmaphorum

MAY 12, 2021

UK biotech MiNA Therapeutics has signed up another big pharma partner for its small activating RNA (saRNA) platform, which upregulates the activity of proteins, with Eli Lilly the latest to get in on the action. . The post Lilly buys into MiNA’s protein-boosting RNA tech in $1.25bn deal appeared first on.

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Drug Discovery World

MARCH 7, 2024

Ginkgo Bioworks has acquired Patch Biosciences, with the intention to strengthen its gene therapy services, cell therapy services, and RNA therapeutics services. JB Michel, CEO and co-founder of Patch Biosciences: “Joining Ginkgo Bioworks represents an exciting step in our journey to engineer better genetic medicines.

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Drug Discovery World

MARCH 21, 2023

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. Genetic engineering The findings build on earlier efforts by genetic engineers, which involved genetically reprogramming E.

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Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials. Why Does the IBC Need to do a Risk Assessment?

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Scienmag

AUGUST 4, 2020

Led by Boyce Thompson Institute’s Andrew Nelson, four partners will identify RNA modifications and develop resources that may lead to hardier crops Credit: Photo credit: Anna Nelson Dittrich ITHACA, NY, August 4, 2020 — RNA perform a variety of functions in cells, helping with everything from regulating genes to building proteins.

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Pharmaceutical Technology

APRIL 20, 2023

Targovax has unveiled plans to rebrand as Circio , reflecting its strategic shift to focus on expediting the development of its innovative circular RNA (circRNA) platform. Initially reported in 2011, CircRNA is a naturally occurring class of RNA.

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Drug Discovery World

MARCH 21, 2024

A project focused on developing a small RNA-based platform technology for treating monogenic diseases, smartRNA, has joined the BioInnovation Institute’s (BII) Bio Studio programme. The technology has platform potential, as it leverages a universal small RNA pathway to target generic mRNA features.

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Scienmag

NOVEMBER 13, 2020

In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis. Credit: Christian Kroun Damgaard and Anne Kruse Hollensen.

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Drug Discovery World

APRIL 18, 2024

By building and iterating on RNA sequences through the CodonCracker software and the Nutcracker Manufacturing Unit, Nutcracker reported that its scientists engineered a group of molecules with attenuated PSMA and CD3 (cluster of differentiation 3) binding to mitigate on-target, off-tumour binding and target-independent T cell activation.

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Engineer Drugs RNA Scientist 52

Scienmag

DECEMBER 16, 2020

New research from the Whitehead Institute suggests that the products of transcription — RNA molecules — regulate their own production through a feedback loop Credit: Jon Henninger/Whitehead Institute At any given moment in the human body, in about 30 trillion cells, DNA is being “read” into molecules of messenger RNA, the intermediary (..)

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Medical Xpress

JANUARY 18, 2023

Researchers at Columbia Engineering and Columbia University Irving Medical Center have invented a new RNA sequencing method that achieves high-quality results from small volumes of frozen tumor specimens.

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Scienmag

OCTOBER 27, 2020

A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing. In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis.

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Genetic Disease RNA Genetics Genome 69

BioSpace

FEBRUARY 24, 2021

Orna, which began as an academic query at the Massachusetts Institute of Technology (MIT), is a biotechnology company creating fully engineered circular RNA, or O-shaped RNA therapies for the treatment of cancer, autoimmune, and genetic disorders.

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RNA Engineer Genetics 80

Outsourcing Pharma

JANUARY 30, 2023

The biotech company emerges with financial banking to support its 3D RNA structure engine.

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Scienmag

SEPTEMBER 30, 2020

Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine Credit: Scott Wiseman for Scripps Research JUPITER, FL – Sept.

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pharmaphorum

APRIL 28, 2022

Harness Safe & Efficacious Lipid-Based Delivery for Novel Therapeutics Beyond RNA & Hepatic Tissue. The Next Generation Lipid-Based Nanoparticles Delivery Summit is your definitive industry-led meeting to design and engineer 2nd generation of lipid nanoparticles for emerging payloads beyond RNA into clinic.

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Pharmaceutical Technology

MAY 25, 2023

The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform. ElevateBio intends to use the funds to advance its genetic medicine current good manufacturing practice (cGMP) and process development business, BaseCamp.

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Scienmag

AUGUST 20, 2020

Some of these structures, such as those found in DNA, RNA and proteins, are formed through complex molecular interactions that are not easily duplicated by inorganic materials. A research team led by Richard Robinson, associate professor of materials science and engineering, discovered a […].

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pharmaphorum

OCTOBER 5, 2022

Sanofi has added to its rare disease pipeline by licensing an antibody-RNA conjugate (ARC) for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder, from US biotech miRecule. billion deal in 2018.

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RNA Genetics Dermatology Antibody 105

Drug Discovery World

JANUARY 6, 2023

Orbit Discovery and start-up SanegeneBio have entered into a Master Service Agreement to identify tissue-specific delivery of a wide range of RNA therapeutics. . The peptide display engine addresses soluble targets and targets in situ, both on and in cells. .

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Drugs RNA DNA Engineer 52

pharmaphorum

JANUARY 5, 2023

However, its messenger RNA (mRNA) platform – building on continuous advances in basic and applied mRNA science – permits the development of therapeutics and vaccines for other infectious diseases, immune-oncology, rare diseases, cardiovascular diseases, and auto-immune diseases as well.

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Pharmaceutical Technology

JUNE 23, 2022

Coronaviruses, like Covid-19, are a notorious group of infectious agents that include a large class of viruses with RNA genomes, similar to the human DNA genome, that depend on well-organised protein structures crucial for viral growth and replication.

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Drug Discovery World

JUNE 22, 2023

Evox Therapeutics has purchased Codiak Biosciences engEx-AAV technology platform, including all intellectual property rights, and exclusive access to certain engineering and manufacturing rights. The post Evox Therapeutics acquires exosome AAV technology from Codiak appeared first on Drug Discovery World (DDW).

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Drug Discovery World

JANUARY 23, 2024

Professor Anubhav Tripathi One of the featured speakers, Anubhav Tripathi, Professor of Medical Science and Engineering at Brown University, will address the topic ‘ Accelerating biotherapeutics development through technology platforms ’ on Tuesday 6 February at 3.30pm.

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XTalks

OCTOBER 21, 2020

Related: Study Dispels Claim that COVID-19-Causing Coronavirus is Lab-Engineered. In addition, Berrio and colleagues discovered other novel targets of positive selection, namely within genes encoding Nsp4 and Nsp16, which are viral enterotoxins important for the stability of the RNA structure of the virus.

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RNA Protein Genome Genomics 98

Drug Discovery World

JANUARY 23, 2023

Following the release of Clarivate’s report ‘RNA Technology Companies to Watch’, DDW’s Diana Spencer speaks to Strand Therapeutics’ Jacob Becraft and HAYA Therapeutics’ Samir Ounzain to find out how this technology could revolutionise disease treatment.

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Drug Discovery World

NOVEMBER 1, 2022

He published ‘maps” depicting how various cell types use alternative splicing of messenger RNA to construct genetic templates that produce an ever-changing set of proteins in the cell. . The SLED package released RNA-producing protein that made the melanoma cells die. . Splicing-linked expression design.

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Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna Genomics general manager and chief scientific officer Eric Huang said: “Through our collaboration with Life Edit, we hope to harness the power of gene editing technologies as part of our broader research and development engine, helping to advance our mission and deliver on the promise of mRNA.”

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Scienmag

OCTOBER 7, 2020

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

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Scienmag

FEBRUARY 7, 2022

It folds the RNA of the virus into a compact structure. The SARS-CoV-2 nucleoprotein is the main protein in viral particles. This is needed to transfer the hereditary material to the “next generations” of virions (viral particles) before they are separated from the infected cell.

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Scienmag

NOVEMBER 11, 2020

“Conditional gene knockout and small interfering RNA […]. Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism.

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Scienmag

MAY 7, 2021

Georgia Tech and Emory researchers use ultrasound to develop delivery system for potent RNA drugs Credit: Ashley Ritchey, Georgia Tech RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality.

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Drug Discovery World

JANUARY 13, 2023

Alliance to develop circular RNA-based therapeutics . Esperovax and Ginkgo Bioworks have agreed a partnership to develop circular RNAs (circRNAs) for a variety of therapeutic applications. . The top stories: . Collaboration to identify up to 10 novel target-antibody pairs .

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Drugs Antibody RNA Engineer 52

Drug Discovery World

OCTOBER 5, 2023

The presentations will be followed by a panel discussion addressing new drug discovery and development concepts and tools in cancer research, and how these new approaches – e.g. engineered proteins, antibodies, micro RNA, nanocarriers, antibody drug conjugates – can help address unmet need in oncology.

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Delveinsight

SEPTEMBER 14, 2021

ADARx bags USD 75 Million to advance its RNA tech pipeline. ADARx Pharmaceuticals, a biotechnology company developing RNA targeting therapeutics , announced the completion of a USD 75 million Series B financing to progress its drug development pipeline. SR One Capital Management and OrbiMed Advisors co-led Series B. Simeon George, M.D.,

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Scienmag

FEBRUARY 4, 2021

Emerging technologies harnessed to develop a faster, cheaper, and more accurate test for these hard-to-diagnose tumors, researchers report in The Journal of Molecular Diagnostics Credit: Tony Ng, MD, PhD, The University of British Columbia Philadelphia, February 4, 2021 – Researchers have leveraged the latest advances in RNA technology and machine (..)

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Scienmag

APRIL 21, 2021

Targeting an RNA to interrupt its activity could improve patient response to therapy and increase their overall survival. […]. Credit: Yutaka Kondo Nagoya University researchers and colleagues in Japan have uncovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients.

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