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Gene editing: beyond the hype

pharmaphorum

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. The genomic medicine journey. Zinc fingers.

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This week in drug discovery (2-6 October)  

Drug Discovery World

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

Drugs 52
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AI-designed protein awakens silenced genes, one by one

The Pharma Data

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

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Why Women with Alzheimer’s Live Longer and Do Better Than Men with the Disease

XTalks

It helps explain why women with the disease survive longer with less severe symptoms than men during the early stages of the Alzheimer’s, despite having the same levels of toxic amyloid beta and tau proteins in their brains. The study was published in the journal Science Translational Medicine. KDM6A Variant.

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The Dose: DDW’s drug discovery highlights

Drug Discovery World

The announcement followed the signing of deals to make new medicines available across the country. . According to the publication, “A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognise mutated proteins specific to a person’s tumours.

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Women in Science Who Have Paved the Way Forward in Genetics

XTalks

Geneticist Martha Chase was a key partner of the foundational Hershey-Chase experiment that helped confirm DNA to be the carrier of genetic information; however, it was only Hershey of the pair that went on to win the Nobel Prize in Physiology or Medicine in 1969 for the discovery. Martha Chase.

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2020 Year in Review: COVID-19, CRISPR and Immunotherapies Define the Year for the Life Sciences

XTalks

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic. CRISPR Gene Editing Inventors Win Nobel Prize.