Scienmag

SEPTEMBER 10, 2020

Findings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […]. (..)

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Scienmag

FEBRUARY 18, 2021

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

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Gene Expression Development Research Gene 72

Drug Discovery World

FEBRUARY 14, 2024

A class of molecules playing a crucial role in the regulation of gene expression and other cellular processes can restore normal skin structure rather than producing a scar, a University of Manchester-led study suggests. The findings offer hope for a solution to the global problem of non-healing wounds, thought to cost between £11.25

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Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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Drugs Gene Editing Genome Genomics 52

Drug Discovery World

SEPTEMBER 27, 2023

Founder Dr Moshe Szyf Founder shares the potential of harnessing precision medicine. Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy.

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Drug Discovery World

OCTOBER 17, 2023

Today, spatial omics technologies enable imaging-based identification of cells in their native tissue context while simultaneously detecting hundreds of RNAs or tens of protein markers in the same cells. RA: Can spatial biology studies help drive advances in precision medicine? Let’s take CAR T cells as an example.

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Gene Expression Drugs Protein Gene 52

The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1). .”

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XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Visium Spatial Gene Expression Solution. Feature barcoding using gel beads. Single Cell Data Analysis.

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Gene Expression Development RNA Drugs 112

Roots Analysis

JANUARY 14, 2024

In fact, biologics are anticipated to play a significant role in shaping the pharmaceutical industry and will eventually serve as an integral part of traditional medicines. Overview of Biologics Biologics refer to medicinal / therapeutic products that are either manufactured using living organisms or semi-synthesized from biological sources.

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XTalks

SEPTEMBER 21, 2020

It helps explain why women with the disease survive longer with less severe symptoms than men during the early stages of the Alzheimer’s, despite having the same levels of toxic amyloid beta and tau proteins in their brains. The study was published in the journal Science Translational Medicine. KDM6A Variant.

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Gene Protein Gene Expression Scientist 89

pharmaphorum

NOVEMBER 22, 2022

Beta catenin meanwhile is a signalling protein in the Wnt pathway – in particular a downstream transcription factor (TCF) implicated in a range of solid tumour types including colorectal, liver, breast, prostate, uterus and lung cancers.

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Drug Discovery World

AUGUST 16, 2023

Triple negative cancers are not driven by any of the three molecules that can be blocked by targeted hormone receptor drugs – the HER2 protein and two hormone receptors for oestrogen and progesterone – and so current treatment options are limited.

Genetics 52

Genetics Gene Hormones RNA 52

Drug Discovery World

NOVEMBER 15, 2022

“The main idea of cell-free systems is to take biological processes, such as gene expression, outside the cell and into a test tube,” says Dr Nadanai Laohakunakorn, University of Edinburgh, who specialises in engineering cell-free systems. This approach has been around for a while.

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DNA Drugs Antibody Engineer 98

XTalks

FEBRUARY 11, 2021

Geneticist Martha Chase was a key partner of the foundational Hershey-Chase experiment that helped confirm DNA to be the carrier of genetic information; however, it was only Hershey of the pair that went on to win the Nobel Prize in Physiology or Medicine in 1969 for the discovery. Martha Chase.

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Genetics DNA Genome Genomics 119

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. These efforts, along with many others, are opening doors for new possibilities in translational medicine. In some aspects, Cas12 and Cas13 are considered superior to Cas9.

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DNA Genome Genomics RNA 98

XTalks

DECEMBER 24, 2020

In addition to pharma and biotech companies who zealously began working to develop COVID-19 drugs and vaccines, companies from areas outside of science and medicine also stepped up to help during the pandemic. Most antibody drugs and vaccines have been developed to target parts of the spike protein.

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pharmaphorum

JANUARY 29, 2021

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. The genomic medicine journey.

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Delveinsight

JULY 30, 2020

The drug, UCB0107, is designed to impede or decrease the buildup of tau proteins in the brain, which leads to nerve cell damage and death. It will push a pipeline of treatments toward the clinic as well as bankroll the recognition of new targets for genomic medicines. Omega Therapeutics is getting a USD 85 million cash boost.

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The Pharma Data

SEPTEMBER 2, 2021

” With a particular focus on the lung, the researchers performed global gene expression analyses of the metastatic niche. They discovered that in the presence of a primary tumor, the endothelial cells lining the interior of blood vessels produced the protein LRG1 (leucine-rich alpha-2-glycoprotein 1) in large quantities.

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Gene Expression Scientist Antibody Research 52

Drug Discovery World

DECEMBER 12, 2022

The announcement followed the signing of deals to make new medicines available across the country. . According to the publication, “A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognise mutated proteins specific to a person’s tumours.

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Drugs Gene Editing Genome Genomics 52

Drug Discovery World

APRIL 21, 2023

Managing all of these elements using iterative design and prototyping can play a key role in successful project delivery, and marrying technologies with biochemical or cellular assays has the potential to bring disruptive change across fields as diverse as personalised medicine, diagnostics and drug screening.

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Drug Discovery World

JULY 15, 2022

This technical tour de force will have far reaching implications for our understanding of the human genome and for practical use of this knowledge in clinical medicine. Nanopore sequencing relies on determination of the chemical composition of the nucleic acids by passing a single strand of nucleic acids through a protein nanopore 6.

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The Pharma Data

AUGUST 3, 2021

The goal of the company’s cancer research is to deliver medicines that offer each patient a better, healthier life and to make cure a possibility. HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression.

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XTalks

AUGUST 12, 2020

Studies have identified the presence of two types of HIV-infected CD4+ T cells: ‘Transcriptionally inactive’ cells that do not typically produce viral RNA or viral proteins. Fucosylation is the attachment of a specific sugar molecule called fucose to proteins on the surface of cells. T Cell Glycomic Signatures in HIV.

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RNA Protein DNA In-Vivo 52

Drug Discovery World

FEBRUARY 6, 2023

RNA-Sequencing (RNA-Seq) is a revolutionary technology that enables researchers to assess gene expression changes in thousands of genes over time. Intelligent methods of analysing this complex data are also constantly being developed and will become useful tools for future clinical trial design in the era of precision medicine.

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Drug Discovery World

DECEMBER 15, 2022

Potential solutions: For CRISPR systems, the likelihood of off-target editing has been shown to be influenced by a variety of factors, ranging from the design of the gRNA 1 and Cas9 protein 2 , to the targeted cell type 3 , to name a few examples.

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Gene Editing Gene In-Vivo Genome 52

Drug Discovery World

JANUARY 23, 2023

A second generation CRISPR-Cas gene editing system, base editing, reduces the risk of potentially deleterious effects associated with other gene editing technologies, presenting a safe and effective means of editing cells for therapeutic applications. Dis Model Mech. 2020;13:dmm042317. doi:10.1242/dmm.042317. Nat Commun. 2020;11:810.

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Gene Editing Gene Engineer DNA 52

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. ASOs are short single-stranded nucleotides that bind to specific messenger RNAs and prevent the production of a particular protein.

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RNA Protein Genetics Gene Expression 40

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.

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Genome Genomics Genetics Gene 40

The Pharma Data

MAY 13, 2021

The Yale Journal of Biology and Medicine. Preventive Medicine Reports. Experimental & Molecular Medicine. Journal of addiction medicine. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Neuroendocrinology of obesity. Br Med Bull.

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