Drug Discovery World

OCTOBER 6, 2023

The top stories: mRNA pioneers Katalin Karikó and Drew Weissman receive Nobel prize The Nobel Assembly at Karolinska Institutet has awarded the 2023 Nobel Prize in Physiology or Medicine jointly to Katalin Karikó and Drew Weissman for their discoveries that enabled the development of mRNA vaccines against Covid-19.

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XTalks

DECEMBER 24, 2020

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. For example, investment in mRNA vaccines and viral vectors came well before January, many years before it.

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Drug Discovery World

AUGUST 1, 2022

This technology defines gene expression patterns from rare cells harbouring latent HIV by generating millions of single-cell reaction containers in the form of water-in-oil emulsions, in which messenger RNA capture and virus DNA detection can be performed sequentially while maintaining segregation among cells.

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Pharmaceutical Technology

JUNE 4, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

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Drug Discovery World

JULY 10, 2023

The algorithms work by inputting the gene expression profiles of cancers cells to predict how each individual cancer will respond to chemotherapeutic drugs. More so, the success of mRNA vaccines throughout the Covid-19 pandemic has seen pharma take those approaches and apply them to other disease areas, including oncology and HIV.

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Drug Discovery World

NOVEMBER 29, 2022

The technology can contribute to the development and production of vaccines and drugs for severe diseases much faster and at lower cost. . The AI designs synthetic DNA, where it is easy to modify its regulatory information in the desired direction of gene expression. . The next step is to use human cells.

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Camargo

JULY 27, 2021

Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Expression Considerations.

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Drug Discovery World

FEBRUARY 6, 2023

These technologies allow researchers to get an unprecedented view of human cellular responses to vaccines, therapeutics, or medical devices and play a crucial role in identifying next-generation diagnostic, predictive, and prognostic biomarkers. Given below is a summary of these practices along with some examples of real-world applications.

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Drug Discovery World

MARCH 21, 2023

In July 2022, DDW reported that molecular genetics company Mainz Biomed had enrolled its first patient in an international clinical study assessing the potential combination of gene expression (mRNA) biomarkers with a diagnostic test for colorectal cancer.

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Drug Discovery World

NOVEMBER 15, 2022

“If you want to order gene-length sequences, rather than short oligos for PCR, the waiting times are around two or three weeks at least. One of the challenges we face with SARS-CoV-2 is that the virus continually evolves, making RNA vaccines and antibody therapies less effective. Synthetic libraries for antibody drug discovery .

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Roots Analysis

JANUARY 14, 2024

With the increased interest and gradual shift of investment from small molecule drugs to biologics and the establishment of several biologics manufacturing companies / biologics CMOs, more than 250 biologic therapies and vaccines have been developed, globally.

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Delveinsight

JULY 30, 2020

Omega’s platform is designed to adjust gene expression to healthy levels rather than switching genes on and off. The work of the company is based on the genes and their regulatory elements found in loops of DNA called Insulated Genomic Domains (IGDs).

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Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. RNA interference (RNAi) Therapeutics : Fundamentally, RNAi is a natural process of post-transcriptional gene silencing, involving short strands of nucleic acids.

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The Pharma Data

FEBRUARY 22, 2021

In his laudatory speech, Werner Baumann, Chairman of the Board of Management of Bayer, emphasized the importance of science and transparency in research: “In record time – much quicker than even the most optimistic observers dared to hope – scientists were able to develop various vaccines against the virus. In the Chemistry category Dr.

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Drug Discovery World

DECEMBER 12, 2022

“The study advances our understanding of ADHD by showing how the condition is tied to changes in how certain genes are expressed in the brain. Interesting findings recently came out of the UC San Francisco 6 , where a new approach by researchers has been analysing how well different re-engineered T cells work against cancer.

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Drug Discovery World

OCTOBER 17, 2022

For example, GEO, the gene expression omnibus database, has been collecting gene expression and functional genomics datasets and making them available to the public for more than 20 years. Many efforts have been made to standardise certain types of results. About the author .

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The Pharma Data

DECEMBER 27, 2020

CureVac and the University Medical Center of Mainz launched a Phase III trial of CVnCoV, their COVID-19 vaccine candidate, in healthcare workers. The study will evaluate the safety and immunogenicity of the vaccine in a two-dose schedule of 12 micrograms.

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The Pharma Data

MAY 15, 2021

It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a gene expresses – that is, how the gene affects you – goes on to determine whether you get ill or not.

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XTalks

AUGUST 12, 2020

Xtalks spoke to lead author on the study, Mohamed Abdel-Mohsen, PhD, assistant professor, Vaccine & Immunotherapy Center at the Wistar Institute, about the emerging utility of identifying glycomic, or sugar, signatures on the surface of immune cells to help in their identification and potential targeting.

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The Pharma Data

MAY 13, 2021

Opiate-like effects of sugar on gene expression in reward areas of the rat brain. Hormones (Athens). 2014 Oct-Dec;13(4):458-75. DOI: 10.14310/ horm.2002.1551. 2002.1551. . Spangler R, Wittkowski KM, Goddard NL, Avena NM, Hoebel BG, Leibowitz SF. Brain Res Mol Brain Res. 2004 May 19;124(2):134-42. DOI: 10.1016/j.molbrainres.2004.02.013

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