Medical Xpress

APRIL 17, 2023

Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.

Genetics 75

Genetics Hormones Gene Research 75

Pharmaceutical Technology

JULY 15, 2022

The UK National Institute for Health and Care Excellence (NICE) has recommended Novartis Pharmaceuticals UK’s Piqray (alpelisib) along with hormonal therapy fulvestrant to treat hormone receptor+, HER2-, PIK3CA-mutated locally advanced or metastatic breast cancer.

Hormones 147

Hormones Protein Gene Medicine 147

XTalks

JANUARY 9, 2024

The thyroid plays a critical role in the body by producing hormones that regulate metabolism, heart rate and body temperature among others. Types of Thyroid Conditions There are several different thyroid conditions, with each affecting thyroid hormone production or the gland’s structure, leading to a range of health issues.

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Hormones Antibody Trials Production 105

Drug Discovery World

MARCH 27, 2024

To reduce their risk of relapse, patients undergo five to ten years of hormone therapy to target any remaining cancer cells. I hope our early findings will next lead to research to target these dormant breast cancer cells so that one day, without the need for years of hormone therapy, patients can be sure that their cancer will not return.”

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Research Hormones Regulation Scientist 105

Scienmag

DECEMBER 9, 2021

Credit: SWOG/The Hope Foundation In an analysis of data from postmenopausal patients with hormone receptor-positive breast cancer, a standard measure of gene expression known as the sensitivity-to-endocrine-therapy (SET2,3) index was found to have prognostic value that complemented the known prognostic value of the 21-gene breast recurrence score.

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Medical Xpress

DECEMBER 12, 2022

Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

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Gene Editing Genetics Hormones Medicine 75

Medical Xpress

DECEMBER 6, 2022

Non-Hispanic Black women with hormone receptor (HR)-positive/HER2-negative, lymph node-positive breast cancer had worse outcomes compared to non-Hispanic whites, Asians, and Hispanics, despite similar 21-gene recurrence scores, according to a study presented at the 2022 San Antonio Breast Cancer Symposium, held December 6-10, 2022.

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HR Hormones Genetics Gene 71

Drug Discovery World

AUGUST 16, 2023

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. “Our findings paint a complex picture – with many, dynamic factors driving how tumours respond to treatment.”

Genetics 52

Genetics Gene Hormones RNA 52

Pharma Packaging Solutions

JUNE 30, 2023

Hormones (such as insulin, glucagon, and growth hormone, to name a few) are produced by recombinant DNA, as are blood factors, thrombolytic agents, interferons, monoclonal antibodies, therapeutic enzymes, and more.

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Recombinant DNA Technology Packaging Packaging Gene Therapy 52

Scienmag

DECEMBER 8, 2020

In an article published in the Journal of Pineal Research, researchers at São Paulo State University and collaborators describe a set of genes potentially regulated by the ‘sleep hormone’ in some types of tumor A Brazilian study published in the Journal of Pineal Research describes a group of genes potentially regulated by the hormone melatonin (..)

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Hormones Regulation Gene Research 40

The Pharma Data

OCTOBER 21, 2020

21, 2020 — Low levels of thyroid hormone during pregnancy may contribute to the development of attention deficit hyperactivity disorder in the child, new research suggests. Thyroid hormones play an important role in the growth and development of the fetal brain, especially during the first trimester of pregnancy, the researchers said.

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Hormones Gene Research Medicine 52

pharmaphorum

AUGUST 16, 2022

The study – which included an all-comer population of men with mCRPC – showed that Lynparza plus Johnson & Johnson’s hormonal therapy Zytiga (abiraterone) reduced the risk of disease progression or death by 34% versus Zytiga alone, with radiographic progression-free survival (rPFS) of 24.8 months and 16.6 months, respectively.

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Hormones Gene Sales Trials 111

Pharmaceutical Technology

APRIL 19, 2023

In 2012, Bayer entered a five-year, multi-target collaboration with Evotec which yielded six non-hormonal pre-clinical candidates, two of which advanced to Phase I development: BAY2328065 and BAY2395840.

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Gene Therapy Hormones Production Sales 130

Drug Discovery Today

FEBRUARY 13, 2020

Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations.

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Hormones Gene Genetics Medicine 40

Drug Discovery World

JUNE 2, 2023

The drug is already approved in the US based on results from the PROfound Phase III trial as monotherapy for patients with homologous recombination repair (HRR) gene-mutated mCRPC (BRCAm and other HRR gene mutations) who have progressed following prior treatment with enzalutamide or abiraterone.

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Hormones Gene Trials Drugs 52

Scienmag

APRIL 9, 2021

Researchers at Osaka University define the complex role of SLPI, a secretory leukocyte protease inhibitor, in coordinating the biphasic action of parathyroid hormone on the metabolism of bone Credit: Osaka University Osaka, Japan – Despite what some people think, bone is not merely a passive component of the body.

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Hormones Research Gene Medicine 96

Drug Discovery World

APRIL 6, 2023

Olaparib is PARP inhibitor that targets cancers linked to faulty BRCA1 or BRCA2 genes and works across many different cancer types. Men in England and Wales with advanced, incurable prostate cancer who have BRCA1/2 mutations in their tumours and who have seen their cancer progress despite hormone therapy will also have access to olaparib.

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Hormones Gene Scientist Clinical Trials 52

The Pharma Data

NOVEMBER 24, 2020

25, 2020 /CNW/ – On August 21, 2020 , Health Canada approved Lynparza® (olaparib), for the treatment of adult patients with deleterious or suspected deleterious germline and/or somatic BRCA or ATM- mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with a new hormonal agent (NHA).

Gene 52

Gene Hormones DNA Medicine 52

XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. There are also studies examining gene therapy-based techniques to repair or replace genetic defects contributing to this disease.

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Gene Therapy Gene Life Science DNA 111

XTalks

JANUARY 24, 2022

In developing the vegan casein, Fooditive aims to eradicate the downsides of factory farming, antibiotics, hormones and lactose. And while cow’s milk is a good source of protein and calcium, other ingredients and additives , like natural growth hormones and lactose, can make it hard to digest.

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Gene Splicing Protein Hormones Production 112

Scienmag

MARCH 11, 2021

During pregnancy, the hormone progesterone helps to […]. The study in mice — published online in the Proceedings of the National Academy of Sciences — provides novel insights for developing treatments.

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Hormones Development Research Gene 74

XTalks

NOVEMBER 26, 2020

In addition to innovative new antibody drugs and mRNA vaccines, researchers have found that the sleep-regulating hormone melatonin may also offer protection against COVID-19. The study was published in the journal PLOS Biology. Related: Can Vitamin D Be Beneficial for COVID-19 Patients?

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Research Hormones Protein Regulation 98

The Pharma Data

DECEMBER 9, 2020

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer that had spread to only one to three lymph nodes, and who had a low risk of recurrence. WEDNESDAY, Dec.

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Hormones Trials Medicine Clinical Trials 52

pharmaphorum

JULY 14, 2022

Piqray (alpelisib) meanwhile is a once-daily, oral PI3K inhibitor that has been cleared for use in combination with hormonal therapy (fulvestrant) for hormone receptor-positive, HER2-negative, PIK3CA-mutated locally advanced or metastatic breast cancer, that has progressed after endocrine and CDK4/6 inhibitor therapy.

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Drugs Hormones Genome Genomics 104

pharmaphorum

JANUARY 16, 2023

Hormone replacement therapy (HRT) could cut the risk of Alzheimer’s in some women at elevated risk of the disease, according to researchers in the UK.

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Hormones Genotype Research Genetics 75

pharmaphorum

MARCH 8, 2021

The cost-effectiveness agency is assessing use of Lynparza (olaparib) in patients with tumours that carry BRCA1 or BRCA2 mutations who have previously been treated with the hormone therapies abiraterone and enzalutamide but have relapsed.

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Hormones Marketing Trials DNA 98

pharmaphorum

MAY 6, 2022

For Pluvicto that includes a pair of phase 3 trials in metastatic hormone-sensitive prostate cancer and metastatic castration-resistant prostate cancer, while for Lutathera it will affect studies for brain cancer glioblastoma, extensive-stage small cell lung cancer, and new NET indications.

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Manufacturing Hormones Clinical Trials Clinical Trials 52

Drug Discovery World

JULY 20, 2022

Now, a new study has shown that a combination of immunotherapy and a drug that blocks a common gene mutation in lung cancer could work as an effective treatment. . The KRAS gene is part of the RAS family of genes which are found in about 20% of all cancer, including melanoma, bowel cancer and pancreatic cancer. .

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Gene Clinical Trials Clinical Trials Scientist 52

Scienmag

DECEMBER 7, 2020

University of Pennsylvania biologists have uncovered one way plants respond to hormonal cues. A similar process is likely at play in mammals. Just like other organisms, plants must respond dynamically to a variety of cues over their lifetime.

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Hormones Gene Genetics Medicine 63

Drug Discovery World

SEPTEMBER 7, 2022

The National Institute of Health and Care Excellence (NICE) has confirmed its decision not to recommend olaparib for previously treated metastatic prostate cancer in patients with BRCA gene mutations. The Institute of Cancer Research (ICR) has called the decision ‘disappointing’ and ‘frustrating’. Biomarker testing “should be routine”.

Genetics 52

Genetics Drugs DNA Gene 52

pharmaphorum

SEPTEMBER 24, 2021

The results of the PROpel study showed that a combination of Lynparza (olaparib) and Johnson & Johnson’s hormonal therapy Zytiga (abiraterone acetate) given as a first-line treatment to an -all-comer’ population of men with metastatic castration-resistant prostate cancer (mCRPC) delayed disease progression.

Hormones 52

Hormones Genetics Sales Drugs 52

The Pharma Data

SEPTEMBER 3, 2020

Comparing four separate forms of the disease, they found that samples of the most aggressive form, known as metastases-like primary tumours, saw changes in activity of 74 immune-related genes, compared with changes in only 12 in the more benign insulinoma-like tumours.

Research 52

Research Genetic Analysis Gene Scientist 52

XTalks

SEPTEMBER 17, 2020

Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed. By reducing the amount of growth hormone in the blood, progressive enlargement of bones should be slowed.

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Trials Gene Hormones Clinical Trials 98

Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

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Hormones Marketing Gene Trials 52

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. Gene switches are sites on genes where regulatory molecules can bind to trigger transcription process, leading to expression of a particular gene.

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Gene Gene Therapy Gene Expression Regulation 40

Drug Discovery World

APRIL 4, 2023

The decision will enable the company to include the US in the global Phase II portion of its ongoing Phase I/II study of NTLA-2002, an in vivo genome editing candidate designed to inactivate the target gene, kallikrein B1 (KLKB1).

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FDA Approval In-Vivo Gene Editing Drugs 52

XTalks

AUGUST 15, 2023

Akeega is a dual-action tablet (DAT) that contains the company’s androgen receptor-targeting hormone therapy Zytiga (abiraterone acetate) and PARP inhibitor (poly [ADP-ribose] polymerase inhibitor) niraparib. Lynparza received FDA approval in May 2020 for mCRPC in patients with homologous recombinational repair ( HRR ) gene mutations.

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