Genetically engineered dendritic cells enhance lung cancer therapy
Drug Discovery World
APRIL 9, 2024
To help enhance the effectiveness of immune checkpoint blockade, the UCLA team explored injecting immune-stimulating, chemokine gene-engineered dendritic cells directly into the tumour. The scientists genetically modified dendritic cells to produce CXCL9 and CXCL10 and then injected these directly into the tumours in mouse models of NSCLC.
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