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Genetically engineered dendritic cells enhance lung cancer therapy

Drug Discovery World

To help enhance the effectiveness of immune checkpoint blockade, the UCLA team explored injecting immune-stimulating, chemokine gene-engineered dendritic cells directly into the tumour. The scientists genetically modified dendritic cells to produce CXCL9 and CXCL10 and then injected these directly into the tumours in mouse models of NSCLC.

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FDA Approves Genetically Engineered Pigs for Food, Possible Medical Use

The Pharma Data

FDA Approves Genetically Engineered Pigs for Food, Possible Medical Use. 14, 2020 — The first genetically engineered pigs for use as food or for potential future biomedical use — such as transplantation — in humans have been approved by the U.S. Professional. MONDAY, Dec. Food and Drug Administration.

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Genetically engineered T cells could lead to therapies for autoimmune diseases

Scienmag

A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.

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Synlogic’s SYNB1934 receives orphan drug status from US FDA

Pharmaceutical Technology

SYNB1934 consumes Phe in the gastrointestinal (GI) tract by leveraging genetic engineering of the drug or drug-carrying capsule, probiotic escherichia coli (E coli) Nissle. SYNB1934 has also gained rare paediatric disease designation (RPDD) from the FDA and orphan drug designation from the European Medicines Agency (EMA).

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Stimulating axon regrowth after spinal cord injury

Medical Xpress

A new study by Burke Neurological Institute (BNI), Weill Cornell Medicine, finds that activation of MAP2K signaling by genetic engineering or non-invasive repetitive transcranial magnetic stimulation (rTMS) promotes corticospinal tract (CST) axon sprouting and functional regeneration after spinal cord injury (SCI) in mice.

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Engrafting Bacteria for Therapeutic Advantage in Kidney-Related Diseases

BioSpace

Proof of concept for the Genetically Engineered Microbial Medicines (GEMM) platform came in a recent first-in-human, Phase I trial.

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Immune therapy targets cells that cause leukemia relapse

Scienmag

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.