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ERC Grants €2.5 Million to TIGEM Researcher for Advancing Programmable Genetic Circuits

Scienmag

At the forefront of this paradigm shift is Professor Diego di Bernardo, Genomic Medicine Program Coordinator at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and Professor of Biomedical Engineering at the University of Naples “Federico II.” His groundbreaking project, DIMERCIRCUITS, backed by a prestigious €2.5

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Aging And Schizophrenia Share Striking Similarities in 2 Types of Brain Cells

AuroBlog - Aurous Healthcare Clinical Trials blog

Similar genetic changes in two different types of brain cells may contribute to cognitive impairment in schizophrenia and aging. US researchers examined gene expression in more than a million brain cells collected post-mortem from 191 donors.

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Researchers speed identification of DNA regions that regulate gene expression

Scienmag

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.

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In Vivo Mapping of Human Enhancer Mutagenesis

Scienmag

Despite their importance, the fine-scale functional landscape within these regulatory sequences has remained elusive, hindering our ability to interpret the consequences of genetic variation in human disease contexts. Enhancers act as molecular switches that integrate signals and guide gene expression programs.

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Early-life social connections influence gene expression, stress resilience

Scienmag

Strong social connections and greater maternal care early in life can influence molecular markers related to gene expression in DNA and future stress response, suggests a […]. Holekamp Having friends may not only be good for the health of your social life, but also for your actual health–if you’re a hyena, that is.

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Stanford Researchers Identify Missing Yew Tree Enzymes Crucial for Producing Common Cancer Drug

Scienmag

Unlocking these enzymes would enable transferring their genetic blueprints into fast-growing industrial microorganisms, like yeast, converting them into microbial factories that produce Taxol on scales far surpassing what nature offers. This comprehensive gene set promises to transform industrial drug manufacture.

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CAMP4’s funding influx paves the way for tapping regulatory RNA to treat urea cycle disorders

Pharmaceutical Technology

However, in patients with urea cycle disorders, genetic defects result in inadequate amounts of the enzymes needed to convert nitrogen into urea. Ultragenyx uses adeno-associated virus 8 (AAV8) gene therapy to induce stable OTC gene expression. Their platform identifies which regRNAs control the specific gene of interest.

RNA 245