Scienmag

JUNE 23, 2025

This expands the horizon for therapeutic targeting of TAF2, making it a gene of exceptional interest in the oncology field at large. Published in the prestigious journal Hepatology in May 2025, this pioneering study combines molecular genetics, cell biology, and clinical oncology to chart a novel course for HCC research.

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Medical Xpress

JANUARY 18, 2023

New research from the Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has identified 45 genes whose gene expression is associated with body mass index (BMI), many of which have not been previously explored in obesity research, after the researchers conducted a study using a multiethnic cohort.

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Scienmag

MARCH 9, 2021

CHOP researchers find small changes in RNA due to RNA editing could have a large impact on gene expression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence (..)

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Scienmag

OCTOBER 1, 2020

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. . — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.

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Scienmag

JUNE 20, 2025

Reader proteins that detect these m^6A marks act as molecular interpreters, directing downstream processes that govern gene expression programs. The study thus reveals a nuanced, multifactorial scheme whereby dynamic acetylation controls the epitranscriptomic reader activity and shapes stress-responsive gene expression.

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Medical Xpress

FEBRUARY 3, 2023

A trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock. For their paper published in the journal Science, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project.

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BioSpace

JULY 11, 2022

Epic Bio aims to transform genetic medicine by developing a new class of drugs that target the epigenome to alter gene expression.

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Scienmag

JUNE 18, 2025

Unlike genetic mutations that alter DNA sequences, epigenetic modifications reconfigure gene expression through reversible chemical changes, offering unique insights into tumor biology and promising avenues for therapeutic intervention.

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XTalks

APRIL 29, 2025

Unlike traditional treatments that target specific proteins or pathways, epigenetic approaches work by modulating gene expression without altering the underlying DNA sequence. This strategy leverages the complex network of the epigenome that dictates which genes are turned on or off.

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Scienmag

DECEMBER 21, 2020

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. “The difference is within us,” says Vivek Chandra, Ph.D.,

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Medical Xpress

MARCH 8, 2023

Scientific evidence shows how the cognitive decline in Alzheimer's disease (AD) is caused by the buildup of amyloid beta proteins, which promote synaptic malfunction.

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Scienmag

DECEMBER 22, 2020

Blocking gene expression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. The new compound prevents the genetic information within mitochondria from being read. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria.

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Scienmag

JULY 12, 2021

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […].

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XTalks

FEBRUARY 21, 2025

Current Share Price: PWS is a complex, genetically determined neurodevelopmental disorder that affects multiple organ systems. And hyperphagia is common not only to PWS but also to hypothalamic obesity, binge-eating disorder and certain rare genetic disorders like Bardet-Biedl syndrome.

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Scienmag

MAY 27, 2021

Cellular proteins get their marching orders from genetic instructions encoded in DNA, whose sequences are first copied and made […].

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Drug Discovery Today

APRIL 24, 2023

Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that variations in chromatin accessibility, and thus gene expression, may explain why people of European descent with APOE4 gene variants have a greater risk of developing Alzheimer’s disease than people of African descent with similar genetics.

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Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off.

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Scienmag

JUNE 20, 2025

The discovery challenges long-standing assumptions about this epigenetic mark, traditionally linked to active gene transcription, by revealing its essential structural function in transcriptionally silent oocytes. To explore the developmental implications further, the team subjected H3K4me3-deficient oocytes to in vitro fertilization assays.

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BioTech 365

APRIL 9, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue (..)

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Scienmag

JUNE 22, 2025

The results showed marked changes in gene expression pertaining to lipid metabolism, adipogenesis, and endocrine regulation within the larvae. The study involved sourcing recycled polyethylene pellets from various geographical locations, which were then immersed in water for a 48-hour period to assess the leachate.

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Scienmag

JUNE 12, 2025

TF binding comparison revealed widespread differences between inbreds, driven largely by structural variation, that correlated with gene expression changes and explained complex quantitative trait loci such as Vgt1 , an important determinant of flowering time, and DICE , an herbivore resistance enhancer.

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pharmaphorum

OCTOBER 12, 2021

The research has focused on Alzheimer’s associated with an apolipoprotein E4 (APOE4) gene variant known to be a major risk factor for late-onset forms of the disease. The results are strong enough to back a proof-of-concept study in people with genetic risk of Alzheimer’s according to the researchers.

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Scienmag

JUNE 12, 2025

Investigating genetic variations, signaling pathway alterations, and molecular subtypes can aid in patient stratification. Emerging research reveals that ICCA’s heterogeneity—manifested in histological diversity, genetic mutations, and molecular subtypes—dictates clinical behavior and therapeutic response.

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XTalks

AUGUST 5, 2020

Visium Spatial Gene Expression Solution. To address challenges associated with loss of spatial context, 10x Genomics has developed the Visium Spatial Gene Expression solution, which enables answering biological questions in the context of tissue using an unbiased gene expression approach.

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Medical Xpress

DECEMBER 20, 2024

An international research team, including researchers at Karolinska Institutet, has mapped the genes expressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented in the journal Neuron, is hoped to contribute to more personalized treatment of MS in the future.

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pharmaphorum

NOVEMBER 12, 2021

It could also be made more powerful by incorporating personal genetic information and gene expression profiles in tissues such as the lungs, they suggest.

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Scienmag

FEBRUARY 23, 2021

Credit: Sorbonne Université Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage (..)

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Scienmag

JUNE 17, 2025

The UCSF team employed an advanced single-cell sequencing platform developed within their lab, allowing unprecedented resolution insight into the genetic and molecular underpinnings of these diverse tumors.

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Pharmaceutical Technology

JUNE 13, 2023

Ziftomenib targets the menin-KMT2a protein-protein interaction that may occur in patients with KMT2ar or NPM1m genetic alterations. The aberrant protein complex is essential for regulating leukaemia-promoting gene expression. Thus, targeting menin may be an effective strategy for patients with high unmet needs.

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Scienmag

SEPTEMBER 28, 2020

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of (..)

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XTalks

MARCH 7, 2024

Breast Cancer Multiomics: Unified Insights in Tumor Heterogeneity This on-demand webinar introduces a cutting-edge single-cell multiomics method designed for garnering detailed genetic insights into breast cancer. The test accurately identified a range of genetic abnormalities, including trisomies and microdeletions.

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Scienmag

SEPTEMBER 29, 2020

By changing gene expression first, some immunotherapies may work better, models show Credit: (courtesy of Hackensack Meridian Health) September 29, 2020 – Nutley, NJ – A one-two punch of changing gene expression, then deploying immune checkpoint inhibitors, shows promise in battling one of the most treatment-resistant types of cancer in (..)

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Scienmag

JUNE 18, 2025

Focusing on the nematode Caenorhabditis elegans , an organism prized for its transparent anatomy and genetic tractability, the investigators pinpointed the amphid sensory organ as a model system for dissecting neuron-glia interactions. The choice of the C.

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The Pharma Data

JUNE 11, 2025

Angelman syndrome is a complex genetic disorder that causes profound developmental delays, intellectual disability, speech impairment, problems with movement and balance, and seizures. It is typically caused by the loss of function of the maternal copy of the UBE3A gene.

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Pharma Marketing Network

DECEMBER 21, 2020

Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e., those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies.

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Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

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