Scienmag

JULY 22, 2021

Strong social connections and greater maternal care early in life can influence molecular markers related to gene expression in DNA and future stress response, suggests a […]. Biology Ecology/Environment GeneticsCredit: Kay E.

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Scienmag

MAY 6, 2021

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Biology Gene Therapy Genes Genetics Medicine/Health

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Scienmag

OCTOBER 1, 2020

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. Chemistry AND Physics Biology Biomechanics/Biophysics Biomedical/Environmental/Chemical Engineering Cell Biology Genetics Medicine/Health Technology/Engineering/Computer ScienceCHAMPAIGN, Ill.

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Scienmag

JULY 12, 2021

Technology and Engineering Biology Biomedical/Environmental/Chemical Engineering Biotechnology Cell Biology GeneticsThe function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […].

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Scienmag

MARCH 9, 2021

CHOP researchers find small changes in RNA due to RNA editing could have a large impact on gene expression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, […]. Chemistry AND Physics Biochemistry Genes Genetics Medicine/Health Microbiology

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Scienmag

DECEMBER 21, 2020

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease.

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Scienmag

MAY 27, 2021

Cellular proteins get their marching orders from genetic instructions encoded in DNA, whose sequences are first copied and made […]. Chemistry AND Physics Biochemistry Bioinformatics Biology Biomechanics/Biophysics GeneticsCapturing how RNA polymerase enzymes kick off transcription On scales too small for our eyes to see, the business of life happens through the making of proteins, which impart to our cells both structure and function.

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Scienmag

SEPTEMBER 10, 2020

Medicine & Health Biology Genetics Medicine/HealthFindings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […].

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XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Visium Spatial Gene Expression Solution.

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Scienmag

SEPTEMBER 29, 2020

Biology cancer Clinical Trials Genetics Medicine/Health

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Scienmag

FEBRUARY 23, 2021

Mathematics Computer Science Genes Genetics Mathematics/Statistics Medicine/Health Mental Health Molecular Biology Neurobiology

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Scienmag

NOVEMBER 26, 2020

For the first time, researchers describe how Rho protein really stops gene expression COLUMBUS, Ohio – New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly turned off. Chemistry AND Physics Biochemistry Biology Cell Biology Genetics Microbiology Technology/Engineering/Computer Science

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Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. Medicine & Health Biology Developmental/Reproductive Biology GeneticsPULLMAN, Wash. – Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder.

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Scienmag

JUNE 14, 2021

The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” is published in the journal Translational Psychiatry by researchers […]. Chemistry AND Physics Addiction Alcohol Genetics Medicine/Health Neurochemistry Pain Pharmaceutical Sciences

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Scienmag

SEPTEMBER 28, 2020

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of […]. Medicine & Health Biology cancer Cell Biology Genetics Metabolism/Metabolic Diseases Neurochemistry Physiology

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Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in partnership with a key […]. Cancer Biology cancer Cell Biology Genes Genetics

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Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina.

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Gene Expression Gene Research Cardiology 56

Scienmag

DECEMBER 22, 2020

Blocking gene expression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. The new compound prevents the genetic information within mitochondria from being read.

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Camargo

JULY 27, 2021

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19.

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Pharma Marketing Network

DECEMBER 21, 2020

Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e., With over 100 late-stage gene therapy trials underway and an increasing number of gene-editing technologies entering trials, it’s clear that this trickle will soon become a torrent.

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Pharma Phorum

OCTOBER 12, 2021

The research has focused on Alzheimer’s associated with an apolipoprotein E4 (APOE4) gene variant known to be a major risk factor for late-onset forms of the disease.

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XTalks

FEBRUARY 11, 2021

This has ushered in a new era of genomics that is fostering rapid, detailed and personalized insights into human genetics. Here is a profile of some of those brilliant women who helped shape genetics research. Rosalind Franklin: From Chemistry to Genetics.

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Pharma Phorum

NOVEMBER 12, 2021

It could also be made more powerful by incorporating personal genetic information and gene expression profiles in tissues such as the lungs, they suggest.

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XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself.

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The Pharma Data

JULY 12, 2021

“This is mostly because drugs that work perfectly in preclinical inbred models, such as laboratory mice, that are genetically or otherwise identical to each other, don’t translate to patients in the clinic, where each individual and their disease is unique.

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XTalks

SEPTEMBER 21, 2020

A study from the University of California San Francisco (UCSF) has revealed that women with Alzheimer’s do better than men with the disease due to a genetic advantage conferred by their extra X chromosome. The Active Gene. One of these doubly active genes is KDM6A.

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The Pharma Data

JULY 11, 2021

On the other hand, they can inhibit specific enzymes that regulate the accessibility to the genetic material and thus the gene expression in the T cells.

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XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself.

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CATO Research

NOVEMBER 5, 2020

Noteworthy, in addition to established risk factors such as cytogenetic aberrations, the gene expression patterns of the malignant cells can also help to better predict prognosis. Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma. Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.

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Genotoxicity Gene Expression Clinical Trials Clinical Trials 43

Pharma Phorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy.

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Gene Therapy Gene Expression Gene DNA 56

Pharma Phorum

FEBRUARY 22, 2021

Bluebird Bio’s decision to hit pause on the launch of Zynteglo for beta thalassaemia after two cases of cancer were seen in a clinical trial could see fears over the safety of viral vectors used to deliver gene therapies resurface. .

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The Pharma Data

NOVEMBER 8, 2020

BOSTON–( BUSINESS WIRE )– Decibel Therapeutics , a clinical-stage biotechnology company developing novel restorative gene therapeutics to treat hearing loss and balance disorders, today announced the closing of an oversubscribed Series D financing, which raised $82.2M. The program, developed in collaboration with Regeneron Pharmaceuticals, uses a proprietary, cell-selective promoter to precisely control gene expression in cochlear hair cells. 9, 2020 11:00 UTC.

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XTalks

NOVEMBER 6, 2020

The Burnaby, BC-based company developed the oral DNA-based vaccine using its proprietary bacTRL Gene Therapy Platform, which uses genetically modified bifidobacteria as carriers of genetic vaccine elements on a DNA plasmid. The gene therapy-based vaccine targets mucosal tissues in the gastrointestinal tract, allowing for greater selectivity and targeted delivery compared to traditional vaccines. BacTRL Gene Therapy Platform.

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XTalks

MARCH 22, 2021

Using a simple, standard blood sample, the assay can detect actionable genetic mutations in cancers, including cancer-driving alterations. The tool analyzes the differential expression of over 90 genes to distinguish between 50 tumors types and subtypes.

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The Pharma Data

JANUARY 19, 2021

Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today announced that it has priced an underwritten public offering of 4,000,000 shares of its common stock at a public offering price of $11.00 Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. CAMBRIDGE, Mass.,

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The Pharma Data

MAY 15, 2021

I was recently reminded of my journey out of the HCT nightmare as I watched a documentary about gene therapy. Gene therapy is a huge deal – some gene therapies are already achieving jaw-dropping results for people with previously untreatable illnesses.

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Pharma Phorum

JANUARY 29, 2021

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome.

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The Pharma Data

DECEMBER 14, 2020

Combining DetermaRx with our products for genetic testing and MRD detection (currently under R&D), we can provide a comprehensive testing strategy for oncologists to ultimately benefit Chinese early-stage NSCLC patients by improving their survival and quality of life.

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Delveinsight

JANUARY 18, 2021

Angelman syndrome (AS) is a complex genetic rare disorder that affects the nervous system. Angelman syndrome is a result of the missing or dysfunctional gene known as UBE3A. Thus, restoring the presence of this particular gene can help to restore several of the functions of the brain.

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The Pharma Data

DECEMBER 27, 2020

STP705 is a small interfering RNA (siRNA) therapy that leverages a dual-targeted inhibitory property and polypeptide nanoparticle (PNP)-enhanced delivery to knock down both TGF-beta1 and COX-2 gene expression.

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The Pharma Data

FEBRUARY 22, 2021

Before, she was associate professor at Cornell University in the Department of Molecular Biology and Genetics. Her cryo-electron microscopy studies include analysis of nuclear peripheries and the machinery of gene expression in bacteria. The Bayer Foundation has awarded Ruth Ley PhD with the Otto Bayer Prize, endowed with 75,000 euros.

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Gene Expression Scientist Bacteria Life Science 40

The Pharma Data

JULY 8, 2021

24,25) Expression of TSLP is increased in the airways of patients with asthma and has been correlated with disease severity.(24,26) This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

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The Pharma Data

NOVEMBER 9, 2020

1,2 Expression of TSLP is increased in the airways of patients with asthma and has been correlated with disease severity. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

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