pharmaphorum

OCTOBER 19, 2022

million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. Nucleome’s platform adds 3D genomic information to a wealth of available genomic data, uncovering a new dimension of information that is disease as well as cell type-specific.

Genome 59

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Drug Discovery World

AUGUST 16, 2023

Decoding ‘junk DNA’ The Human Genome Project and subsequent studies discovered that most of our DNA (approximately 98%) does not actually code for proteins, with humans having approximately 20,000 tox 25,000 protein-coding genes. This leads to potentially severe, debilitating and unbearable toxicities for patients.

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pharmaphorum

MARCH 12, 2021

The UK regulator has authorised Eli Lilly’s targeted cancer drug Retsevmo for tumours with RET fusion positive lung cancers and thyroid cancers, which the company said could herald a new era of genomic medicine for the NHS. The post New era of genomic medicine begins as UK approves Lilly’s Retsevmo appeared first on.

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Scienmag

APRIL 15, 2021

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos Credit: MPI of Immunobiology and Epigenetics, F. Zenk The DNA molecule is not naked in the nucleus. This […].

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Drug Discovery World

JULY 18, 2023

Global health science solutions company Revvity, PerkinElmer’s Life Science and Diagnostics business’ new name and branding , has announced the establishment of a Scientific Centre of Excellence in Cambridge, UK. Focused on driving genomic insights to accelerate therapeutic discovery, Revvity’s Scientific Centre of Excellence supports the company’s (..)

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BioPharma Reporter

SEPTEMBER 19, 2023

The UK startup Broken String Biosciences has raised a $15 million Series A round to fund the development of a DNA sequencing platform that maps off-target DNA breaks resulting from genome editing technology.

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AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 11, 2023

The drug regulator, in a drug alert issued, said that a batch of Typbar, manufactured by Bharat Biotech International Ltd in Genome Valley in Hyderabad, Telangana, failed […]

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Outsourcing Pharma

SEPTEMBER 12, 2023

The AstraZeneca-owned company Alexion has teamed up with Verge Genomics to deploy the U.S. startupâs drug discovery platform in the search for novel drug targets for rare neurodegenerative and neuromuscular diseases.

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BioTech 365

OCTOBER 26, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: A ‘genomic rosetta stone’ for discovering the rules of gene regulation.As

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Pharmaceutical Technology

MAY 25, 2023

The Yellow Card biobank will launch as a joint venture with the UK-government funded entity Genomics England on June 1. According to the press release, the MHRA will be the first drug safety regulator in the world to pilot such a biobank. Genomics England will assist the MHRA with sequencing and genetic material storage.

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Drug Discovery World

MARCH 30, 2023

Neoantigens are produced by specific tumour viruses, integrated into the genome and are abundantly expressed only in tumour cells with strong immunogenicity and tumour heterogeneity. The post Chinese regulator approves personalised cancer vaccine trial appeared first on Drug Discovery World (DDW).

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BioPharma Reporter

OCTOBER 4, 2022

Alexion, AstraZeneca Rare Disease will acquire LogicBio Therapeutics, an American genomic medicine company.

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BioPharma Reporter

JULY 20, 2023

London-based precision medicine software provider Lifebit has partnered with two population genomic initiatives in Mexico and Brazil to help diversify genomic research and reduce health inequality in Latin America.

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BioPharma Reporter

FEBRUARY 25, 2021

A program at the University Hospital of TÃbingen is the first in Germany to use whole genome sequencing (WGS) to improve the diagnosis of rare diseases and hereditary cancers.

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The Pharma Data

MARCH 7, 2022

Decision Regarding Slick-Haired Cattle is Agency’s First Enforcement Discretion Decision for an Intentional Genomic Alteration in an Animal for Food Use. IGAs are alterations made using molecular technologies that introduce changes to the genome of an animal. Today, the U.S. Solomon, D.V.M., Related Information. Source link: [link].

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BioTech 365

DECEMBER 8, 2021

BRAIN Biotech AG / Key word(s): Miscellaneous/Patent BRAIN Biotech AG: Additional Differentiated Genome-Editing Nuclease: BRAIN-Metagenome-Cas 01 (BMC01) 08-Dec-2021 / 14:53 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by DGAP … Continue reading →

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BioPharma Reporter

JUNE 23, 2022

BIO, the worldâs largest trade association for the biotech industry, has responded to the US Food and Drug Administration's draft guidance on developing human gene therapy products that incorporate genome editing (GE) of human somatic cells.

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Gene Therapy Genome Genomics Gene 59

Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

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DNA Regulation Genome Genomics 62

BioTech 365

AUGUST 6, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Comprehensive catalogue of the molecular elements that regulate genes.A 17-year research project has generated a detailed atlas of the genome that reveals the location of hundreds of … Continue reading →

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Regulation Gene Genome Genomics 40

BioTech 365

MAY 6, 2021

BRAIN Biotech AG / Key word(s): Miscellaneous BRAIN Biotech AG: First Development Phase for a novel Genome Editing Tool Completed (CRISPR Cas) 06-May-2021 / 17:54 CET/CEST Disclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) … Continue reading →

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Drug Discovery World

FEBRUARY 12, 2024

In the upcoming year, we will see the expansion of new, more complex markets and updated requirements from regulators. The challenge is harnessing the power of AI within a highly regulated industry. The key challenge for all regulators next year is ensuring that they can keep up with the progress of the technology.”

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Scienmag

DECEMBER 7, 2021

A new paper in Genome Biology and Evolution, published by Oxford University Press, maps out for the first time how Hydra, which are a group of small aquatic animals, can regenerate their own heads by changing the way that their genes are regulated, known as epigenetics.

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BioPharma Reporter

FEBRUARY 21, 2022

PerkinElmerâs Sirion Biotech business is teaming up with the Centre for Genomic Regulation (CGR) to jointly develop new generation adeno-associated virus (AAV) vectors for type 1 and type 2 diabetes gene therapy in the pancreas.

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Gene Therapy Gene Development Genome 98

Scienmag

OCTOBER 29, 2021

A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes.

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Pharmaceutical Technology

JUNE 5, 2023

Regulators need to work together with industry to certify hot patches to quickly fix vulnerabilities while maintaining pharmaceutical quality,” adds Fracchia. Pharmacies have also received EU General Data Protection Regulation (GDPR) fines for not being in compliance,” he adds. “Right now, it’s compliance by checkbox, in a static way.

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Outsourcing Pharma

SEPTEMBER 14, 2023

company Rome Therapeutics plans to use the proceeds of its $72 million Series B round to take an experimental autoimmune disease treatment through early clinical testing.

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Scienmag

JANUARY 11, 2022

LA JOLLA—(January 11, 2022) What determines how a cell’s genome is regulated to ensure proper growth and development? Turns out, the parts of the genome that are turned on or off in each cell-type or tissue play a major role in this process. Now, a team at Salk has shown that the CLASSY gene family […].

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Outsourcing Pharma

NOVEMBER 1, 2023

Element Biosciences, Inc., will share news of its sequencing methodology and host a workshop on higher accuracy sequencing for improved variant detection in Washington DC from today.

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Scienmag

MARCH 12, 2021

Credit: The Wistar Institute PHILADELPHIA — (March 12, 2021) — Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome […].

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BioPharma Reporter

MAY 7, 2024

Broken String Biosciences, a genomics company driving cell and gene therapy developing, has entered a research collaboration with the Francis Crick Institute, a biomedical discovery institute dedicated to understanding the biology underlying health and disease.

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Gene Therapy Research Genome Genomics 52

Pharmaceutical Technology

SEPTEMBER 9, 2022

It is expected to expedite the development of a wide range of new therapeutics using the small non-coding area of the genome that is not explored. The mutations were expected to regulate biological pathways that are related to a clinical syndrome. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.

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Scienmag

OCTOBER 27, 2021

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is. We now know that proteins are not just the products of genes, but that they also interact with genes, influencing and regulating the rhythm of their expression.

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pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

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Drug Discovery World

OCTOBER 19, 2023

The EU regulation of the European Medicines Agency (EMA) is also being adapted to mirror the FDA’s regulations. Paediatric tumours have different genomic drivers and phenotypes than adult tumours, requiring unique preclinical models.

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BioPharma Reporter

NOVEMBER 10, 2021

The company recently opened a manufacturing and commercial hub in Singapore, making the facility its first outside of the US.

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Genome Genomics Manufacturing Regulation 101

XTalks

MARCH 7, 2024

In a pivotal move for the food industry, the US Food and Drug Administration (FDA) has unveiled industry guidance for genome edited foods derived from plants. Genome editing stands as a cutting-edge technique that ingeniously introduces new traits into plants.

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Gene Editing Gene Genome Genomics 52

pharmaphorum

FEBRUARY 25, 2022

A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Prior to this latest development, research into the human ZGA was limited to human embryos at a later stage of growth, under stringent UK regulations.

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