Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

DNA 62

DNA Regulation Genome Genomics 62

The Pharma Data

MARCH 7, 2022

Decision Regarding Slick-Haired Cattle is Agency’s First Enforcement Discretion Decision for an Intentional Genomic Alteration in an Animal for Food Use. The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. Today, the U.S.

Genome 52

Genome Genomics Production Marketing 52

Drug Discovery World

SEPTEMBER 27, 2023

Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy. Genetic variations inherited from our parents shape our response to drugs, disease susceptibility, physiology and metabolism.

DNA 115

DNA Genetics Gene Medicine 115

Scienmag

OCTOBER 27, 2021

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is. We now know that proteins are not just the products of genes, but that they also interact with genes, influencing and regulating the rhythm of their expression.

Gene 72

Gene Genome Genomics Genetics 72

Drug Discovery World

FEBRUARY 27, 2024

DDW’s Megan Thomas speaks with Dr Blythe Sather, Vice President and Head of Research at Tune Therapeutics, about how genetic tuning will transform the reach for CAR-T therapies, the different diseases that can benefit, and the disruptive technology making this happen. MT: What is genetic tuning?

Gene Expression 59

Gene Expression DNA Genetics Gene 59

XTalks

SEPTEMBER 30, 2020

The research shows that the activity of the immune messenger type 1 interferon (IFN) protein is diminished, either by genetic mutations or an autoimmune attack by neutralizing antibodies against it, in a subset of COVID-19 patients. Casanova’s lab is now searching for the genetic driver behind the autoantibodies. percent of men.

Antibody 135

Antibody Genetics Research In-Vitro 135

XTalks

MARCH 7, 2024

In a pivotal move for the food industry, the US Food and Drug Administration (FDA) has unveiled industry guidance for genome edited foods derived from plants. Genome editing stands as a cutting-edge technique that ingeniously introduces new traits into plants.

Gene Editing 52

Gene Editing Gene Genome Genomics 52

pharmaphorum

JANUARY 29, 2021

Genome editing is an exciting but still nascent field, and companies in the area face as many obstacles as they do opportunities. ZFPs can be engineered to make zinc finger nucleases, or ZFNs, which are proteins that can be used to edit genomes by knocking select genes in or out to specifically modify DNA sequences.

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Gene Editing Gene Gene Therapy In-Vivo 145

FDA Law Blog

MAY 25, 2022

Javitt — On April 19, FDA issued a safety communication regarding genetic non-invasive prenatal screening, commonly referred to as non-invasive prenatal tests or NIPT ( here ). NIPT are intended to screen for genetic abnormalities in a fetus. FDASLA incorporates a modified version of the VALID Act.

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Regulation Genetics In-Vitro Development 40

Drug Discovery World

MARCH 21, 2023

Although this technique is broadly used, predicting its efficiency when aimed at certain points in the genome can be challenging, making it hard to reliably overexpress certain genes. For example, genes that contain H3K9me3 repressing regulators, and therefore are shielded from activation, showed greater variation in response.

Research 52

Research Gene Gene Editing Genome 52

The Pharma Data

AUGUST 28, 2020

FoundationOne Liquid CDx analyses more than 300 cancer-related genes and multiple genomic signatures to help inform treatment decisions for all solid tumour cancers. Many cancer patients are unable to have a tissue biopsy. Source link.

Genome 52

Genome Genomics Regulation Gene 52

XTalks

JULY 14, 2022

However, there is limited knowledge about the upstream regulators of most genes. CRISPR-Cas9 gene editing was used to simultaneously perturb thousands of genes by targeting specific points of genetic code. They found that many of the regulators controlled each other through numerous interconnected feedback loops.

Gene 98

Gene Regulation Protein Gene Editing 98

FDA Law Blog

MARCH 3, 2024

The Act is intended to address national security concerns by prohibiting certain conduct by regulated industry. Biotechnology companies of concern include BGI (formerly Beijing Genomics Institute), MGI, Complete Genomics, WuXi Apptec, and any subsidiary, parent, affiliate, or successor of such entities.

Genome 102

Genome Genomics Manufacturing Production 102

pharmaphorum

JULY 20, 2022

Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert. Recently, studies have suggested large tracts of it have some form of biological function, including the regulation of genes themselves.

DNA 113

DNA Scientist Genome Genomics 113

Drug Discovery World

MARCH 2, 2023

Epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome. But the new findings answer a fundamental and longstanding question – how epigenetic proteins regulate the processes of transcription and gene expression, through which our genes are read and translated into proteins.

Gene Expression 52

Gene Expression Gene DNA RNA 52

pharmaphorum

DECEMBER 21, 2021

In a recent webinar held by pharmaphorum, in partnership with IQVIA, a discussion was held looking at how to make academic and commercial medical research more efficient, while also looking at the opportunity of genomic data to bring benefits to patients and healthcare systems. The potential to leverage genomic data.

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Development Genome Genomics Drugs 98

Drug Discovery World

APRIL 17, 2024

Recently, research published by Dr Richard (Rick) Young (Whitehead Institute) describes the key mechanism of how these regRNAs regulate gene expression. So, regRNAs haven’t been exploited previously because scientists have only recently understood their role in regulating gene expression. Can you give some examples?

Gene Expression 59

Gene Expression Gene Genetic Disease RNA 59

Scienmag

AUGUST 5, 2020

A long-running national collaboration has produced a comprehensive catalogue of the molecular elements that regulate our genes Credit: Ella Maru Studio A 17-year research project has generated a detailed atlas of the genome that reveals the location of hundreds of thousands of potential regulatory regions – a resource that will help all human (..)

Genome 53

Genome Genomics Regulation Gene 53

Drug Discovery World

OCTOBER 4, 2023

Scientists have long known that there may be a genetic component that confers predisposition to depression, but the specific underlying mechanisms have remained elusive. Parallel findings in humans underscored the involvement of interferon-related genes in major depressive disorder.

Research 52

Research Gene DNA Gene Expression 52

Scienmag

NOVEMBER 16, 2020

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. Genome Med 12, 89 (2020). Singapore scientists uncover potential role of long non-coding RNAs in pancreatic cancer Credit: From Figure 4 in Liu, S., Harmston, N., Glaser, T.L.

In-Vivo 53

In-Vivo RNA DNA Genome 53

XTalks

MARCH 18, 2024

By genetically editing microorganisms, scientists can now manipulate the metabolic pathways to produce foods with desirable properties. The precision fermentation study highlights how genetically engineered microorganisms can inhibit the growth of foodborne pathogens.

Genetic Engineering 52

Genetic Engineering Genetics Production Protein 52

Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a […].

Gene Expression 41

Gene Expression DNA Genome Genomics 41

Pharmaceutical Technology

FEBRUARY 3, 2023

The field of genomic medicine has reached a true turning point. With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more.

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Genome Genomics Medicine Gene Therapy 244

Drug Discovery World

NOVEMBER 27, 2023

In addition, it has stimulated increased collaboration among drug developers, technology providers, supply chain organisations, and regulators. Anis also serves on the scientific and editorial advisory board of Genetic Engineering News , Mary Ann Liebert, Inc.

Production 59

Production Engineer Gene Editing Gene 59

Drug Discovery World

MARCH 7, 2023

More research work focuses on dissecting the genetic architecture of other diseases such atrial fibrillation and arrhythmia,” Dr Saad says. More research work focuses on dissecting the genetic architecture of other diseases such atrial fibrillation and arrhythmia,” Dr Saad says.

Biobanking 52

Biobanking Drugs Genome Genomics 52

Drug Discovery World

FEBRUARY 6, 2024

However, many have cautioned against too great a reliance on these tools and emphasised the importance of checks and balances to ensure the systems are properly regulated and results are verified. Automation is also being applied to genomics sample preparation, an area that requires particular robustness and scalability.

Marketing 69

Marketing Medicine Genome Genomics 69

Drug Discovery World

MAY 5, 2023

Anthony Schmitt , PhD, Senior Vice President, Science at Arima Genomics, discusses the applications of 3D genomics in cancer research. But what about the patients whose genomic tests do not identify a cancer driver matched to an existing targeted therapy? with regards to detecting cancer driver mutations.

Genome 52

Genome Genomics Gene Genetics 52

pharmaphorum

MARCH 10, 2021

bluebird bio is to ask regulators to restart clinical studies of its LentiGlobin for sickle cell disease, after an investigation concluded that a case of acute myeloid leukaemia (AML) was “very unlikely” to be caused by the gene therapy. bluebird bio’s Philip Gregory. Shares in bluebird ticked up following the announcement.

Gene Therapy 59

Gene Therapy Gene Trials Gene Expression 59

The Pharma Data

JULY 11, 2021

Since then, there has been an increasing body of findings that the microbiome, which is sometimes also referred to as the second human genome, is not only of central importance for digestion, but also influences, if not controls, at least a large number of body functions. The immune system is mentioned particularly frequently.

Bacteria 52

Bacteria Genetics Regulation Scientist 52

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase.

Protein 52

Protein Genome Genomics Research 52

Drug Discovery World

MAY 17, 2024

Cancer trials are notorious because they are dependent on the genetic profile of patients and hence highly-selective. The researchers delved into the genetic makeup of tumours, recognising that genetic mutations heavily influence how tumours respond to drugs. There are more – regulations, validations and integrations.

Trials 52

Trials Clinical Trials Clinical Trials Protein 52

Advarra

SEPTEMBER 29, 2022

Informed consent is one of the central protections the regulations provide to research subjects. The regulatory requirements for informed consent will vary depending upon which regulations apply to the conduct of a particular study. The regulations are very specific regarding what to include in the ICF and what to exclude.

Regulation 52

Regulation Research Genetics Compliance 52

The Pharma Data

SEPTEMBER 7, 2020

US regulators have approved Genentech’s Gavreto (pralsetinib) for the treatment of adults with metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC). The personalised cancer treatment has received conditional approval in the US. Source link.

FDA Approval 52

FDA Approval Genome Genomics Genetics 52

pharmaphorum

SEPTEMBER 14, 2020

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential.

Genome 117

Genome Genomics Medicine Gene 117

Worldwide Clinical Trials

DECEMBER 12, 2022

Genetic testing provides patients with a diagnosis for their illness, helps patients and family members to understand risks of developing new diseases, and can be used to support clinical trial advancement. What are the benefits and limitations to using genetic testing? It is important to consider the type of testing performed (e.g.,

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Clinical Trials Clinical Trials Genetics Trials 130

Pharmaceutical Technology

JUNE 30, 2022

Analysing almost eight thousand tumours across 33 different cancers, researchers say this marks the first time that a framework was created to understand the role of internal factors in driving such genomic alterations. Genomic research have greatly expanded our understanding of disease pathophysiology over the years.

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Genome Project Genome Genomics DNA 130

XTalks

APRIL 5, 2021

The Human Genome Project could not have succeeded without the use of bioinformatics. Specific skills are required to succeed in this job; these include advanced writing skills for scientific literature, developing software tools, working on genome sequencing projects, and designing DNA sequencing libraries. Bioinformatics Engineer.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59