Medical Xpress

MARCH 29, 2023

Their study, "Endothelial-Specific Expression of CIDEC Improves High-Fat Diet-Induced Vascular and Metabolic Dysfunction," published in Diabetes focuses on vascular function and its association with metabolic diseases like insulin resistance, type 2 diabetes, and cardiovascular disease.

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XTalks

NOVEMBER 2, 2021

The government of Scotland has rolled out a new C-peptide test for type 1 diabetes that could help patients monitor their insulin levels with greater accuracy. The test provides information about the amount of insulin a patient has in their body, which can help determine whether they can reduce or stop taking their insulin injections.

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BioPharma Reporter

MAY 12, 2022

These are some of the questions we will be asking leading experts next week.

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Scienmag

MAY 17, 2022

Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts. These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Credit: CABBI Plasmids have extensive […].

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Velocity Clinical Research

JUNE 27, 2023

Rosenstock is the lead investigator for Novo Nordisk’s ONWARDS 1 program exploring the first investigational once-weekly insulin. “In In ONWARDS 1, insulin icodec allowed people to spend significantly more Time in Range, with comparable Time below Range vs. once-daily basal insulin glargine U100,” said Dr. Rosenstock. “A

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XTalks

FEBRUARY 8, 2024

for a one-month supply Why it did so well: Jardiance belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, inhibiting the SGLT2 protein in the kidneys to lead to the excretion of excess glucose through the urine. In its 2022 financial report, Sanofi reported that sales of the long-acting insulin dropped 27.6

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Delveinsight

AUGUST 18, 2021

In Type 2 diabetes, the body cells become resistant to insulin. The pancreas produces insulin that helps glucose get into cells to be used for energy. Due to Type 2 diabetes, either the body doesn’t make enough insulin or it doesn’t use insulin properly as a result the blood glucose or blood sugar gets too high.

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FDA Law Blog

AUGUST 12, 2021

On July 30, 2021, FDA approved Semglee (insulin glargine-yfgn), an insulin product that relies on Lantus (insulin glargine) as its reference product. So, it remains to be seen if and when interchangeable Semglee will have any meaningful effect on insulin prices in the near future.

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The Pharma Data

JULY 15, 2021

Protomer’s proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. Eli Lilly and Company (NYSE: LLY) today announced the acquisition of Protomer Technologies (“Protomer”), a private biotech company.

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The Pharma Data

MARCH 3, 2022

Patients taking the oral blood pressure medication not only required less daily insulin two years after first diagnosis of the disease, but also showed evidence of surprising immunomodulatory benefits. Type 1 diabetes is an autoimmune disease that causes loss of pancreatic beta cells, which produce endogenous insulin.

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Drug Discovery World

NOVEMBER 16, 2022

Juvena Therapeutics, a biotechnology company scaling a computational platform to map the therapeutic potential of secreted proteins, has raised $41 million in an oversubscribed Series A, bringing its total funding to $50 million. This platform is applicable across a wide scope of disease indications.

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Drug Discovery World

NOVEMBER 1, 2023

The platform is designed to offer pharmaceutical companies and researchers novel and flexible services to grow small-batch crystals of protein-based pharmaceuticals and other key pharmaceutically relevant molecules for research.

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Drug Discovery World

JULY 29, 2022

Australian researchers based may be a step closer to preventing Type 1 diabetes after identifying a crucial protein that could prevent the autoimmune disease from taking hold. Type 1 diabetes is a potentially life-threatening chronic condition in which the pancreas produces little or no insulin.

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XTalks

SEPTEMBER 15, 2020

In addition to the vaccine, the company is also developing an investigational drug called Remygen for the regeneration of endogenous insulin production and to improve hormonal response to hypoglycemia; trials to test the treatment are currently ongoing in patients that have been living with type 1 diabetes for more than five years.

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Drug Discovery World

JANUARY 31, 2024

Alpelisib is a protein-targeted medication that is used for treating breast cancer and overgrowth disorders in children. The medication regulates cell growth, proliferation and development and insulin signalling.

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Pharmaceutical Technology

JUNE 29, 2022

Specialty enzymes are proteins that can act as very specific biocatalysts to accelerate reactions and produce the desired target molecule in pharmaceuticals,” explains Kristoffer Laursen, Head of R&D at Novo Nordisk Pharmatech. “In In the evolving biotechnology industry, enzymes are important process aids.

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Drug Discovery World

MARCH 21, 2023

The work promises to reduce the threats of viral contamination when harnessing bacteria to produce medicines such as insulin as well as other useful substances, such as biofuels. coli to make all their life-sustaining proteins from 61 sets of genetic building blocks, or codons, instead of the naturally occurring 64.

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pharmaphorum

FEBRUARY 28, 2022

Biocon’s partnership with Mylan – which merged with Pfizer’s Upjohn to form Viatris in 2020 – dates back more than a decade and has generated a number of biosimilars including insulin analogues, antibodies and recombinant proteins.

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Roots Analysis

JANUARY 14, 2024

Biologics activate certain proteins or cells in your immune system to create specific responses to targets, while many conventional systemic drugs activate the entire immune system in a more generalized manner. Insect cell lines have been frequently used as recombinant protein expression systems.

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The Pharma Data

MAY 13, 2021

Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake. The insulin-like effect of muscle contraction. Exercise and insulin sensitivity: a review. Exercise and insulin sensitivity: a review.

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XTalks

FEBRUARY 8, 2021

They include proteins, monoclonal antibodies and vaccines that are considered to be “ highly similar ” to biological products that have already been approved by the FDA. Significantly, insulin was deemed to be a biologic as of March 23, 2020, making it a reference product for the development of biosimilar versions.

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Drug Discovery World

JANUARY 15, 2024

OHB-607 is a recombinant version of insulin-like growth factor-1 (IGF-1), a key driver of foetal growth and development, and its binding protein, IGFBP-3. Babies born at less than 28 weeks gestational age have low levels of IGF-1 and face high risk of severe bronchopulmonary dysplasia (BPD), which may lead to chronic lung disease.

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The Pharma Data

FEBRUARY 1, 2021

. “Metformin can improve insulin sensitivity and correct high insulin levels by reducing the amount of insulin and insulin-like growth factor circulating in the body, which may activate cell signals involved in cancer,” Sandler said.

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XTalks

AUGUST 17, 2020

protein-based biologics) and vaccine treatments. protein-based biologics) : are those which bind to specific components (i.e. A growing area in the immunotherapy space is the development of biological modulators, which are genetically engineered proteins that target specific components of the immune system.

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Trialfacts

NOVEMBER 26, 2023

In summary, the main question that we want to answer with this study is: “Does lifting light weights in older men and women while consuming dairy protein, promote glycemic response, muscle gains and improve the ability to get around?” Why Participate? Participants will receive a free consultation with a nutritionist.

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Drug Discovery World

MAY 25, 2023

Research has shown that metabolism + inflammation leads to insulin resistance in type 2 diabetes. However, she has identified FFA4, a G protein-coupled receptor (GCPR) with the therapeutic potential to improve insulin sensitivity in metabolic disorders.

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Drug Discovery World

NOVEMBER 14, 2022

Alternative to insulin. Australian researchers identified a crucial protein that could prevent type 1 diabetes from taking hold. . Find out more: New human beta cell model enables discoveries in diabetes research . Find out more: Collaboration to develop AAV vectors for diabetes gene therapy .

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Delveinsight

DECEMBER 7, 2020

The test identifies Ubiquitin and Glial Fibrillary Acidic Protein (GFAP)- 2 brain-specific protein biomarkers- that appear rapidly in the blood of a patient after a brain injury. The device is worn on the patients’ body, which contains a biharmonic cartridge in it that carries insulin and glucagon.

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XTalks

SEPTEMBER 28, 2023

Using rBST results in higher concentrations of insulin-like growth factor 1 (IGF-1), a protein typically present in milk. There’s been varied research regarding the synthetic hormone’s association with breast cancer.

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The Pharma Data

NOVEMBER 11, 2020

ADDS IN VITRO PHARMACOLOGY AND EXPANDS PROTEIN SCIENCES. She quickly started to collect money for an X-ray apparatus and continued the X-ray analysis of natural products with a research focus on sterols and other biologically interesting molecules, including insulin and penicillin.

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Roots Analysis

MARCH 21, 2022

These devices can be used for controlled delivery of small molecules, as well as large macromolecules ( such as insulin, growth hormones, immunobiological vaccine, receptor agonist, proteins and peptides ). This can be attributed to their relatively more efficient and patient friendly mode of drug delivery.

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XTalks

SEPTEMBER 22, 2020

It is an inhibitor of subtype 2 sodium-glucose transport proteins (SGLT2), which functions in glucose reabsorption. Compared to other anti-diabetic drugs, such as sulfonylurea derivatives and insulin, SGLT2 inhibitors are associated with a low risk of hypoglycaemia.

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Roots Analysis

JANUARY 23, 2024

The peptide therapeutics market has undergone substantial evolution since the inception of insulin. Moreover, these short chains of amino acids, distinct from proteins in their shorter length, serve as essential building blocks for various scientific investigations. Peptide Synthesis Methods: Which are various chemical techniques?

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Delveinsight

AUGUST 20, 2020

Generating insulin-producing pancreatic beta cells from stem cells to substitute those damaged by the immune system is a promising approach for diabetes treatment. Amyloid oligomers are clusters of individual amyloid proteins and represent a target that drugs can hit before full-blown amyloid plaques form.

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Camargo

NOVEMBER 29, 2021

Recombinant therapeutic proteins. Fusion proteins. They may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

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XTalks

SEPTEMBER 17, 2020

Acromegaly Surrogate Endpoint: Serum growth hormone and serum insulin-like growth factor 1 (IGF-1) are acceptable surrogate endpoints for acromegaly clinical trials involving somatostatin analogs such as octreotide, lanreotide and pasireotide. Dietary changes, including restriction of salt and animal protein, are also recommended.

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The Pharma Data

DECEMBER 13, 2020

PXL770 is a first-in-class, oral direct adenosine monophosphate-activated protein kinase (AMPK) activator. AMPK activation has the potential to improve the underlying root causes of NASH, such as insulin resistance, the dysregulation of lipid and glucose metabolism and inflammation. . Placebo.

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