Drug Discovery World

JUNE 9, 2023

The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to DTx Pharma’s DTx-1252, an investigational small interfering RNA (siRNA) therapeutic for the treatment of Charcot-Marie-Tooth Disease Type 1A (CMT1A). “We are pleased to receive Orphan Drug Designation from the FDA for DTx-1252. and Europe.

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Genetics RNA Packaging Packaging 52

Drug Discovery World

JANUARY 17, 2023

Oregon State University College of Pharmacy scientists have shown that lipid nanoparticles and messenger RNA could treat blindness associated with a rare genetic condition. . AAV has limited packaging capacity compared to LNPs and it can prompt an immune system response,” Sahay said. “It

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Gene Editing Gene Gene Therapy Genetics 98

Roots Analysis

OCTOBER 30, 2023

In the past few years, Next Generation RNA therapeutics have emerged as one of the key therapeutic modalities in the modern healthcare industry. These RNA based therapeutics play a crucial role in protein production and regulation of gene functions.

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RNA Vaccination Vaccine Development 40

The Pharma Data

MARCH 7, 2022

The new technique controls gene activity without altering the DNA sequence of the genome by targeting chemical modifications that help package genes in our chromosomes and regulate their activity. Cas9 binds and uses RNA as an address-tag. The AI-designed blocking protein was the cargo of the dCas9-RNA construct.

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Protein Gene Genome Genomics 52

Pharmaceutical Technology

DECEMBER 9, 2022

Our QC testing capabilities range from solids, semi-solids and liquids for oral, inhaled and injectable use to packaging materials, including rubber closures, glass and plastic containers. Ribonucleic acid (RNA) based technologies are among many innovative approaches explored to tackle the Covid-19 pandemic.

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The Pharma Data

DECEMBER 8, 2020

Laying down a new track for RNA processing, Remix launched with $81 million in financing. Funds will be used to support development of the REMaster technology platform and advance the company’s pipeline of RNA processing targeted therapeutics as well. “As Pear Therapeutics. Most read today on BioSpace: Source link.

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RNA Antibody Life Science Protein 52

The Pharma Data

MAY 3, 2021

Pfizer reported that it submitted its application for extension of authorization last week, and EMA announced today that it has undertaken the evaluation of the messenger RNA (mRNA) vaccine. The vaccine has been authorized by the EU for use in people 16 years and up since December 2020. .

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Vaccination Vaccine Antibody RNA 52

The Pharma Data

DECEMBER 16, 2020

Gustave Perna, who oversees the logistics for Operation Warp Speed, told reporters earlier this week that McKesson will package and distribute the vaccine to more than 3,000 sites across the country. The Moderna vaccine is similar to Pfizer and BioNTech’s vaccine in the sense that they both use an approach utilizing messenger RNA (mRNA).

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Vaccination Vaccine Immune Response FDA Approval 52

pharmaphorum

DECEMBER 13, 2021

It, too, announced plans to invest $500 million in a new facility in Africa for the production, fill/finish and packaging of mRNA vaccines. Dormitzer comes from Pfizer, where he was chief scientific officer for RNA and viral vaccines for more than six years. The UK firm also recently hired Phil Dormitzer as head of vaccines R&D.

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RNA Vaccination Vaccine Development 105

The Pharma Data

JANUARY 17, 2021

It received FDA guidance January 5 th and is in the midst of preparing the first package of investigational new drug (IND) applications – usually with an n-of-1, for individual patients. That’s not the case with RNA-targeted drugs. Patient dosing is expected to begin later this year. “No

Genetics 52

Genetics Clinical Trials Clinical Trials Drugs 52

Pfizer

AUGUST 15, 2022

Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course.

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Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development. discoveries!)

Bioinformatics 115

Bioinformatics Genetics RNA Drugs 115

Drug Discovery World

FEBRUARY 6, 2023

This approach has led to the development of two software packages for RNA sequencing analysis and reproducible ribosomal profiling 1,2. For example, we recently collaborated with two sequencing laboratories to determine optimal parameters for RNA-Sequencing (RNA-Seq) in the context of a vaccine clinical trial.

Big Data 52

Big Data RNA Bioinformatics Vaccination 52

Drug Discovery World

MAY 2, 2023

Bacterial RNA is replaced by a synthetic guide RNA (gRNA) that can recognise a specific target DNA sequence. Pooled CRISPR screens usually employ lentiviral libraries comprising gRNA-containing plasmids packaged into lentiviral particles. The gRNA is accompanied by the Cas9 enzyme responsible for cutting DNA.

Genome 52

Genome Genomics Gene DNA 52

Drug Discovery World

FEBRUARY 6, 2024

He discussed how microfluidics assisted synthesis and biologics testing, high throughput automated platforms, functional multiomics screening, artificial intelligence and machine learning have accelerated the development of protein and RNA-based therapeutics.

Life Science 65

Life Science Genome Genomics RNA 65

Pfizer

DECEMBER 13, 2021

The teams started changing existing filling lines, building formulations booths and new filling lines, constructing packaging lines and a “freezer farm,” while recruiting and training new colleagues. 1 They collaborated on methods to purify the RNA using a process called tangential flow filtration, which removes unneeded materials.

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Manufacturing Vaccination Vaccine Production 52

World of DTC Marketing

DECEMBER 29, 2020

Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. These vaccines were developed using different “platform technologies” that involve slotting genetic material from the virus into a tried and tested delivery package.

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The Pharma Data

JANUARY 21, 2021

CABENUVA, a co-packaged kit with two injectable medicines, offers people living with HIV a new approach for maintaining viral suppression. In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 c/mL, meeting noninferiority criteria.

FDA Approval 52

FDA Approval RNA Drugs Containment 52

The Pharma Data

SEPTEMBER 1, 2020

In general, antigen tests have a high specificity, though are not as sensitive as molecular tests that amplify the target viral DNA or RNA sequence in order to generate a quantifiable signal to indicate the presence of the virus in a sample. SARS-CoV-2 Rapid Antigen Test package insert [2] European Centre for Disease Prevention and Control.

In-Vitro 52

In-Vitro Antibody Medicine Clinical Trials 52

Drug Discovery World

JULY 18, 2023

CRISPR diagnostics have successfully detected various pathogens, including RNA viruses (eg. In the context of non- infectious diseases, CRISPR diagnostics have been developed to detect RNA species, such as human CXCL9 mRNA, for kidney transplant rejection. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g.,

DNA 98

DNA Genome Genomics RNA 98

Pfizer

JANUARY 27, 2023

Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course.

Marketing 75

Marketing Production Drugs Licensing 75

The Pharma Data

OCTOBER 19, 2020

Spectrum’s self-contained saliva collection kit provides critical sample consistency while suspending and neutralizing viral RNA transcripts completely inactivating the live virus. Qualified commercial RNA extraction chemistries include Perkin Elmer, Thermo Fisher, Roche, and Qiagen. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

RNA 52

RNA DNA Engineer Packaging 52

pharmaphorum

JUNE 28, 2021

Intellia and Regeneron’s in vivo approach involves administration of a gene-editing drug – in the form of a CRISPR mRNA and guide RNA packaged in a lipid nanoparticle – directly into the body. . — Eric Topol (@EricTopol) June 26, 2021.

In-Vivo 104

In-Vivo Gene Editing Trials Drugs 104

XTalks

FEBRUARY 11, 2021

The RNA is transcribed from DNA in 40-liter vessels containing enzymes and chemicals over the course of three to four days. Given RNA’s instability and high susceptibility to degradation (due to RNAses from other organisms and those lurking in the general environment), the RNA is produced in an extremely high-tech manufacturing suite.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

The Pharma Data

AUGUST 3, 2021

The company confirmed the tirzepatide SURPASS program has met global regulatory submission requirements for evaluating cardiovascular risk and its intention to submit the registration package to regulatory authorities by the end of 2021. Business Development/Other Developments.

Antibody 52

Antibody Sales Development Production 52

Drug Discovery World

DECEMBER 15, 2022

Prime editing, while also employing a single strand nick, expands this scope to all 12 possible changes using a more complex prime editing guide RNA (pegRNA). DNA targeting specificity of RNA-guided Cas9 nucleases . Prime editing can be used for base swapping, as well as for targeted small insertions and deletions. References.

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Gene Editing Gene In-Vivo Genome 52

The Pharma Data

MARCH 20, 2021

Coronaviruses are RNA viruses and include common human coronaviruses, severe acute respiratory syndrome-CoV (SARS-CoV), Middle East respiratory syndrome-CoV (MERS-CoV) and SARS-CoV-2 ( 1 ). INTRODUCTION. SARS-CoV-2 nucleocapsid is highly expressed during infection ( 22 ) and a potential target for viral detection by mass spectrometry.

Protein 52

Protein Antibody Development RNA 52

Pfizer

DECEMBER 13, 2022

Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course.

Drugs 110

Drugs Licensing Licensing Production 110

Pfizer

DECEMBER 20, 2022

Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course.

Drugs 69

Drugs Licensing Licensing Containment 69

XTalks

AUGUST 2, 2023

2) Paxlovid (nirmatrelvir/ritonavir) Paxlovid is a dual-packaged oral medication for the treatment of COVID-19. a month for either 150 mg or 300 mg dose strength packages, and $3,462.13 for the 75 mg dose strength package in January 2023, according to the manufacturer. for a 2-pen package (0.6 for the 3-pen package (1.8

Sales 98

Sales Manufacturing FDA Approval Life Science 98

Pfizer

NOVEMBER 23, 2022

Nirmatrelvir is designed to inhibit viral replication at a stage known as proteolysis, which occurs before viral RNA replication. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course. Our Commitment to Access.

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Licensing Licensing Drugs Manufacturing 40

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced that the primary efficacy analysis of the Phase 3 study of mRNA-1273 conducted on 196 cases confirms the high efficacy observed at the first interim analysis.

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Vaccination Vaccine Medicine Clinical Trials 52

The Pharma Data

MAY 13, 2021

Stimulates DNA and RNA synthesis. You should apply the MindBody Matrix Pain Relief cream 3-4 times per day for the first week after you receive your package. Increases your energy levels by increasing ATP production. Activates and speeds up the lymphatic system. Reduces painful symptoms associated with arthritis.

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Pharmacy Production Doctors Doctor 52

Pharmaceutical Technology

DECEMBER 15, 2022

As the demand for messenger RNA (mRNA) vaccines in southeast Asia increased due to the COVID-19 pandemic, international giants decided to open more manufacturing factories in Singapore. This year, BioNTech (Mainz, Germany) announced plans to acquire a Singapore facility from Novartis for captive capacity vaccine manufacturing.

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Manufacturing Vaccination Vaccine Production 264

XTalks

SEPTEMBER 14, 2020

The company’s candidate vaccine, mRNA-1273, is a synthetic messenger RNA that encodes the stabilized SARS-CoV-2 spike protein. trillion) agreement reached in late July between leaders of the 27 countries in the European Union, a truly historic stimulus package designed to rescue flailing economies from COVID-19.

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Vaccination Vaccine Antibody Life Science 92