Drug Discovery World

MARCH 2, 2023

Scientists at The Institute of Cancer Research, London have revealed how a key epigenetic signal called H3K4me3 determines when and how DNA should be read and translated into proteins within our cells. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

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Pharmaceutical Technology

APRIL 5, 2023

But access to these treatments continues to remain limited due to high price tags and variable availability across regions. Currently, all approved CAR-T therapies are autologous, where T cells taken from patients are modified and then re-infused. AZ: Cell and gene therapies often come with a high price.

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Delveinsight

FEBRUARY 25, 2021

Beam employs three approaches to deliver its genetic medicines to cells. Electroporation is used for ex vivo delivery of therapies to blood and immune cells. The GuideTx technology screens for lipid nanoparticles inside the body that can be used to deliver RNA to cells throughout the body.

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The Pharma Data

MARCH 7, 2022

Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports. “The beauty of this approach is we can safely upregulate specific genes to affect cell activity without permanently changing the genome and cause unintended mistakes,” Levy said.

Protein 52

Protein Gene Genome Genomics 52

pharmaphorum

JUNE 12, 2022

Cases of cancer associated with insertional mutagenesis, caused when the viral vectors used to deliver the gene therapy to host cells, have been seen with bluebird’s gene therapies but have been more apparent in trials involving its CALD and sickle cell disease candidates than beti-cel.

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pharmaphorum

APRIL 14, 2022

million price tag. Beta thalassaemia is caused by a gene defect that impairs the ability of red blood cells to produce haemoglobin, the body’s oxygen-carrying molecule, and is found in around 40,000 new births every year.

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Delveinsight

FEBRUARY 23, 2021

The company plans to use the capital to expand its pipeline of protein-based vaccines and biologic cancer therapies utilizing its innovative and proprietary Trimer-Tag technology platform. Libtayo for First-line Advanced Non-small Cell Lung Cancer Subset. BrainStorm Receives Feedback on BLA Submission for ALS.

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pharmaphorum

JULY 25, 2022

The new drug is one of two bispecifics for multiple myeloma in the late-stage pipeline of J&J’s Janssen division stemming from its longstanding and fertile collaboration with Danish biotech Genmab, along with talquetamab which binds to CD3 and GPRC5D.

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pharmaphorum

AUGUST 18, 2022

bluebird bio’s Zynteglo has become the first cell-based gene therapy to be approved in the US, getting the nod from the FDA as a treatment for patients with beta thalassaemia who require regular blood transfusions. bluebird has opted to launch it at a cost of $2.8 million, which compares to the $1.7

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XTalks

AUGUST 19, 2022

Along with beti-cel, there is one being developed for sickle cell (approved in Europe as Skysona or eli-cel) and another being jointly developed with Bristol Myers Squibb for melanoma. The cells are prepared outside of the body ( ex vivo ) and then infused into the patient. Zynteglo’s hefty price tag of $2.8

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Gene Therapy FDA Approval Gene Clinical Trials 95

Delveinsight

DECEMBER 3, 2020

Roche has got an authorization from the FDA for a more accurate COVID-19 blood test capable of measuring the levels of specific antibodies, which target the cell-unlocking spike protein of coronavirus. An overactivity of complement damages cells in the macula in geographic atrophy. Merck chooses TriNKET cancer immunotherapy program.

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Gene Therapy Gene Antibody Research 52

pharmaphorum

DECEMBER 2, 2020

With fingers in every pie, ranging from small molecules to biologics in every clinical area, to stem cells and consumer goods, Pfizer will surely celebrate its 200th anniversary in as strong a position as it spent the last 160 years. For all the latest Pfizer news follow pharmaphorum’s Pfizer tag.

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Drug Discovery World

NOVEMBER 9, 2023

Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’. Gail Calvert, Field Application Scientist, Sartorius UK, on: ‘Leveraging integrated and advanced technologies for successful cell line development’.

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XTalks

SEPTEMBER 27, 2022

Treatment options prior to Skysona were limited to allogeneic hematopoietic stem cell transplant (allo-HSCT), which has a high risk of serious complications including death, particularly in patients without a human leukocyte antigen (HLA)-matched donor. Related: Bluebird’s $2.8M

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pharmaphorum

FEBRUARY 16, 2021

There is a curative treatment for people who rely on blood transfusions to survive and maintain their levels of red blood cells. But haematopoietic stem cell transplantation is only possible when a donor with a matching human leukocyte antigen signature, within the correct age range, is available. million in Europe.

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Drug Discovery World

NOVEMBER 13, 2023

Alexander Yermanos, PhD, Lecturer, Systems & Synthetic Immunology, ETH Zurich, on: ‘Integrating single-cell immune repertoire sequencing, machine learning, and biophysical properties of antibodies’. He will discuss selection technologies for membrane targets using advances in whole cell panning and comparative deep sequencing.

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Protein Antibody Engineer Scientist 59

The Pharma Data

MAY 13, 2021

Which is one of the only ingredients ever scientifically proven to lower cortisol and block Adamts1’s conversion of stem cells into fat cells. After all, the ingredients we’ve chosen to include in Spade SB-66 are premium ingredients and come with a hefty price tag. FREE SHIPPING. 365 DAY GUARANTEE. Free Shipping.

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Drug Discovery World

OCTOBER 21, 2022

Take, for example, its use for CD4 T cell counting to facilitate HIV monitoring. Flow cytometry is a technique used to rapidly analyse single cells in order to characterise their physical, chemical and biological properties. . Overview, evolution, trends .

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XTalks

FEBRUARY 11, 2021

The Hershey-Chase experiment was actually a set of experiments conducted by Hershey and Chase that helped them conclude that DNA served as the genetic material of a cell. Bacteriophages inject their DNA into cells but not protein, which is mainly a constituent of their outer envelope, or capsid.

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