Scienmag

APRIL 19, 2021

Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner.

Gene 44

Gene Medicine Research Allergies 44

Scienmag

MAY 11, 2021

An international team of researchers at Great Ormond Street Hospital (GOSH), and University of California, Los Angeles (UCLA) have developed a gene therapy that successfully treated 48 out of 50 children with a form of severe combined immunodeficiency that leaves them without an immune system.

Gene Therapy 73

Gene Therapy Gene Development Research 73

Scienmag

OCTOBER 26, 2020

Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus. The pro-viral and anti-viral […].

Gene 74

Gene Research Gene Therapy Allergies 74

Scienmag

DECEMBER 3, 2020

A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.

Genetic Engineering 40

Genetic Engineering Engineer Genetics Bacteria 40

The Pharma Data

AUGUST 7, 2020

As the pharma industry stands firm in its commitment to advance the sector to fight Covid-19, news has emerged from the European Commission who intend to streamline the development of therapies using genetically modified organisms to treat Covid-19. Regenerative medicine and advanced therapies thriving despite Covid-19 disruption.

Clinical Trials 52

Clinical Trials Clinical Trials Gene Trials 52

pharmaphorum

FEBRUARY 16, 2022

She received a cord blood transplant to treat the AML, receiving stem cells carrying a genetic mutation (CCR?5/?32) Having a third functional cure of HIV nevertheless does give pointers to how a more widely applicable cure might be developed in the future, for example using gene-editing drugs to introduce CCR5?32

Gene Editing 67

Gene Editing Research Gene Genetics 67

Scienmag

OCTOBER 25, 2020

Jänne New results from early clinical trials of a drug that targets a cancer-causing mutation in the KRAS gene have shown that it can shrink tumours and is well-tolerated by patients. Latest results from KRYSTAL-1 early clinical trial of adagrasib (MRTX849) Credit: Pasi A.

Gene 53

Gene Clinical Trials Clinical Trials Trials 53

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.

Genome 40

Genome Genomics Genetics Gene 40

Scienmag

OCTOBER 29, 2020

USF Health-led TEDDY analysis focuses on development of multiple distinct autoantibodies targeting insulin-producing cells, from initial autoimmunity to symptomatic type 1 diabetes Credit: Courtesy of USF Health TAMPA, Fla.

Genetics 92

Genetics Insulin Development Clinical Trials 92

Drug Discovery World

AUGUST 1, 2023

Antisense Oligonucleotides (ASOs) ASOs are a type of nucleotide-based therapeutic that are short, synthetic, chemically modified chains of nucleotides that have the potential to target any gene product of interest 2. Though some genetic mutations are harmful, others can be protective.

RNA 52

RNA Drugs Gene Silencing Vaccination 52

Scienmag

DECEMBER 13, 2020

In this type of therapy, T cells, a type of white blood cell, are collected from a patient’s blood and subjected to genetic engineering to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) […].

Genetic Engineering 95

Genetic Engineering Engineer Genetics Allergies 95

XTalks

DECEMBER 24, 2020

From rare disease drug approvals to treatments involving immunotherapies and gene therapies and awarding of a Nobel Prize to the inventors of the gene-editing tool CRISPR, 2020 was a year of great activity and productivity despite the backdrop of the pandemic. CRISPR Gene Editing Inventors Win Nobel Prize.

Life Science 111

Life Science Vaccination Vaccine Gene 111

Scienmag

NOVEMBER 25, 2020

First and corresponding author Dr Lucy van Dorp (UCL Genetics […]. The analysis of virus genomes from over 46,000 people with COVID-19 from 99 countries is published today in Nature Communications.

Genome 58

Genome Genomics Genetics Research 58

Scienmag

OCTOBER 9, 2020

Findings could lay the foundation for the development of effective therapeutic and malaria vaccine strategies, which has largely been hindered by a lack of understanding of the host immune response Credit: Aissatou Diawara Abu Dhabi, UAE, October 9, 2020: The Plasmodium parasite, which transmits malaria to humans through infected mosquitos, triggers (..)

Immune Response 52

Immune Response Gene Research Vaccination 52

The Pharma Data

JULY 8, 2021

The FDA grants Priority Review to applications for medicines that offer significant advantages over available options by demonstrating safety or efficacy improvements, preventing serious conditions or enhancing patient compliance.(1) Results from the NAVIGATOR Phase 3 trial were published in the New England Journal of Medicine in May 2021.

Allergies 52

Allergies Trials In-Vivo Medicine 52

Scienmag

OCTOBER 12, 2020

Mouse immune study gives pointers for development of vaccines and immune therapies Researchers have charted the activity of tens of thousands of genes in mouse immune cells over the course of an infection.

Gene 40

Gene Vaccination Vaccine Development 40

XTalks

DECEMBER 20, 2023

The companies include a diverse range engaged in innovative approaches in areas like oncology, genetic medicines, inflammatory diseases, dermatology and cardiorenal therapy. Bayer’s Astepro (azelastine), an over-the-counter medication for cold, flu and allergies, led the pack in the first half of 2023 with 7.4

Life Science 59

Life Science Clinical Trials Clinical Trials FDA Approval 59

The Pharma Data

MAY 13, 2021

The REAL problem lies in the fact that most of the foods we eat today have been Genetically Modified. food is “A food in which the gene from one species has been forced into the DNA of another species and the process itself creates all sorts of unpredicted side effects.”. A better definition of a G.M.O. When lab rats were given G.M.O.

Production 52

Production Containment Genetics Doctors 52

The Pharma Data

NOVEMBER 9, 2020

9, 2020 /PRNewswire/ — Amgen (NASDAQ:AMGN) and AstraZeneca today announced positive topline results from the Phase 3 NAVIGATOR trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations compared to placebo in patients with severe asthma. THOUSAND OAKS, Calif. ,

Trials 52

Trials Production Sales Manufacturing 52

Scienmag

JULY 14, 2021

Scientists report that the alternative-splicing regulator NSrp70 influences immune T cell development Credit: Gwangju Institute of Science & Technology T lymphocytes, or T cells, are immune cells with diverse roles in building the body’s immunity. How does one particular cell type fight against a host of different pathogens?

Regulation 98

Regulation Scientist Development Allergies 98

Scienmag

JUNE 20, 2021

Researchers shed light on a potential intervention that could make tumors responsive to modern-day immunotherapies Credit: Mei Huang, PhD BOSTON – Researchers from Massachusetts General Hospital (MGH) have discovered a biological mechanism that transforms cells exposed to carcinogens from environmental factors like smoking and ultraviolet light (..)

Research 98

Research Allergies Gene Genetics 98

Drug Discovery World

NOVEMBER 9, 2023

James Cooke, PhD, Associate Director, Bicycle Therapeutics, on: ‘Engineering bicyclic peptides for precision targeted medicine’. Marine Houdou, Genetic Engineering Specialist, Polyplus, on: ‘From modular DNA assembly to recombinant protein production at Polyplus’.

Engineer 52

Engineer Antibody Protein In-Vivo 52

Scienmag

NOVEMBER 24, 2020

Credit: Salk Institute LA JOLLA–(November 24, 2020) Salk Professors Susan Kaech and Alan Saghatelian have been named 2020 Fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society and publisher of the journal Science.

Allergies 62

Allergies Gene Genetics Vaccination 62

Scienmag

FEBRUARY 11, 2021

MUSC Hollings Cancer Center researcher finds loss of STING in recipient dendritic cells increases GVHD severity Credit: MUSC Hollings Cancer Center MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD).

Research 53

Research Gene Therapy Allergies Gene 53

Scienmag

OCTOBER 19, 2020

Garrido, CNIO The sophisticated human immune system has evolved to become an effective protection system against a great number of diseases, cancer being one of them. The immune system recognises and destroys cancer cells using a monitoring process called immunological surveillance.

Dermatology 52

Dermatology Allergies Gene Genetics 52

XTalks

SEPTEMBER 14, 2020

These companies include Moderna, a US biotech company which has formed a partnership with the National Institute of Allergy and Infectious Diseases (NIAID), Oxford University who has partnered with AstraZeneca, and Johnson & Johnson, Merck and Pfizer. Brazil has the second worst outbreak in the world, as it is now reporting over 1.8

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Vaccination Vaccine Antibody Life Science 92