Drug Discovery World

FEBRUARY 8, 2024

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

Gene Therapy 59

Gene Therapy Gene Bioinformatics Life Science 59

Drug Discovery World

JANUARY 23, 2024

For example, enzymes sourced from bacteria living around hydrothermal vents have been used to support the polymerase chain reaction, the test used for Covid-19 detection. ” The ability to collect and analyse such a new wealth of ocean data comes from major developments in DNA sequencing technology and computational power. .

DNA 103

DNA Drugs Gene Scientist 103

The Pharma Data

DECEMBER 13, 2020

Food and Drug Administration (FDA) approved a first-of-its-kind intentional genomic alteration (IGA) in a line of domestic pigs, referred to as GalSafe pigs, which may be used for food or human therapeutics. “The developer of GalSafe pigs participated in this program, proving the impact of this important FDA initiative.

FDA Approval 52

FDA Approval Genome Genomics Production 52

Drug Discovery World

OCTOBER 3, 2023

The event aimed to help the audience understand the AAV workflow, from upstream methods for AAV production and validation to downstream analysis of the packaged product for enhanced therapeutic development. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

Gene Therapy 52

Gene Therapy Gene Life Science Bioinformatics 52

Drug Discovery World

FEBRUARY 6, 2024

From finding potential active substances and identifying novel targets, to simulating how drugs will function in the human body and optimising laboratory workflows, digital technologies are having a significant impact on drug discovery and development. The company’s platform evaluated more than 11.4

Marketing 69

Marketing Medicine Genome Genomics 69

Drug Discovery World

MAY 6, 2024

In this article, DDW’s Diana Spencer highlights several prominent hotspots that are taking the lead on advancing European drug discovery and development. Even before this, however, Amsterdam was established as an important centre for drug development. The CDD will sponsor and manage KWF-supported trials.

Drugs 59

Drugs Life Science Gene Editing Gene 59

Drug Discovery World

JULY 29, 2022

But with hundreds of bacterial species populating our gastrointestinal tract, it’s a daunting task to pinpoint which molecules made by which bacteria affect which biological processes—and how they do so. Such knowledge is essential for learning how to manipulate gut bacteria to treat or prevent illness. New doors open.

Bacterium 52

Bacterium Research Bacteria Immune Response 52

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.

Genome 114

Genome Genomics Medicine Gene 114

pharmaphorum

NOVEMBER 10, 2021

Success, then, will rely on an integrated response that focuses on surveillance, stewardship, and intervention accessibility across the spectrum of human, animal, and environmental health, said the report, which was commissioned to assess the progress of the 2014 National Strategy for Combating Antibiotic-Resistant Bacteria. Surveillance.

Medicine 100

Medicine Genome Genomics Genotype 100

Drug Discovery World

APRIL 25, 2024

Reece Armstrong offers an overview of cell line development and outlines the benefits the technology is bringing to biopharmaceutical developers. Cell line development is an essential underpinning of the drug development process, enabling teams to test, optimise and manufacture therapeutics at a commercial scale.

Development 59

Development Protein In-Vivo Life Science 59

XTalks

NOVEMBER 3, 2023

CRISPR works as genetic scissors to edit parts of the genome. The CRISPR-Cas9 gene editing system was first discovered to be endogenous in bacteria. The companies used data from the 1,000 Genomes Project but from that, only 61 datasets made the cut to encompass the ideal patient population. “I

Gene Therapy 59

Gene Therapy Gene Gene Editing In-Vivo 59

The Pharma Data

JULY 11, 2021

It is believed to be involved in the development of chronic inflammatory intestinal diseases, to trigger diabetes, to be responsible for obesity, even neurological diseases such as multiple sclerosis and Parkinson’s could have their causes here – not to mention depressions and autistic disorders.

Bacteria 52

Bacteria Genetics Regulation Scientist 52

Scienmag

MAY 27, 2021

Credit: LIU Yang Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a technique to sort and sequence the genome of bacteria in soil one bacterial cell at a time, while also identifying what its function is in the soil environment. […]. (..)

Bacteria 67

Bacteria Development Research Genome 67

The Pharma Data

OCTOBER 19, 2020

. “Innovation in cancer treatment is realized through collaboration, and the physicians and researchers at Emory’s Winship Cancer Institute have consistently shown their commitment to developing novel cancer therapies using this collaborative approach,” said Chadi Nabhan , M.D., Ramalingam , M.D.,

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

XTalks

DECEMBER 17, 2021

Given the rapid development of the vaccines and the relative unfamiliarity of new technologies like mRNA technology among the public, vaccine hesitancy has been an ongoing issue that has hindered vaccine uptake in some cases. Young children are most affected by the deadly disease in the continent of Africa.

Life Science 98

Life Science Vaccination Vaccine Trials 98

XTalks

DECEMBER 14, 2022

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

Gene Editing 98

Gene Editing DNA Gene Gene Sequencing 98

Drug Discovery World

JULY 26, 2023

An industry overview of the role of the microbiome in precision medicine, and its interplay with research tools, diagnostics, and therapeutic development. These novel tools are facilitating the exploration of the microbiome in diagnostics development and drug discovery. At the heart of these diagnostics is the sequencing process.

Medicine 52

Medicine Genome Genomics Bioinformatics 52

Pharmaceutical Technology

FEBRUARY 26, 2023

The idea behind these treatments relies on altering the gut microbiome by designing therapeutics that contain bacteria derived from donated stool samples. Although research here is about 20 years old, it remains new compared to other areas like genomics, says Gilbert.

Bacteria 278

Bacteria Trials Research Medicine 278

Drug Discovery World

AUGUST 10, 2022

And as researchers study all of these factors, they are also discovering that CAR T cell development and manufacturing require a new approach to quality control to ensure their safety and efficacy. Developing the first CAR T cell therapy. These treatments have shown success in treating a variety ofcancers 4.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

The Pharma Data

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell , could have implications for gene editing therapies as well. In bacteria with unaltered tracr-L, levels of CRISPR-related genes were low. The authors found that tracr-L redirects Cas9 in S.

Bacteria 52

Bacteria Gene Editing Research RNA 52

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Years of development and fast-paced research have continued to unlock its potential, expanding how CRISPR can be used to treat, detect, and prevent common diseases such as cancer and Covid-19.

DNA 98

DNA Genome Genomics RNA 98

The Pharma Data

DECEMBER 2, 2020

Howard Mayer, Ipsen’s head of research and development, called the Fast Track designation for Onivyde “an extension of Ipsen’s focus and contribution” to the oncology landscape. The goal is to develop a first-in-class treatment for Staphylococcus aureus infections and thereby prevent exacerbation of pneumonia.

Drugs 52

Drugs Gene Editing Genome Genomics 52

Drug Discovery World

OCTOBER 4, 2022

Rebecca McClellan, Scientific Program Manager, Research, Development & Communications, explains how scientists are learning more about the connections between the microbiome and human health to potentially develop first-in-class microbiome therapies. Building the ark.

Research 52

Research Bacteria Scientist Bacterium 52

Drug Discovery World

MAY 2, 2023

In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. In the event of an attack from similar bacteriophages, the bacteria can recognise these segments and use this to discern and cleave the viral DNA, which disrupts the viral gene function.

Genome 52

Genome Genomics Gene DNA 52

The Pharma Data

DECEMBER 31, 2020

When brains develop, they constantly grow new neuronal connections—synapses—as they learn and remember. New Class of Antibiotic Works Against Range of Bacteria. Isoprenoids are required for cell survival in most pathogenic bacteria. Rhesus Macaque Genome Reference Includes 85 Million Genetic Variants.

Antibody 52

Antibody Research Bacteria Genetics 52

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. mRNA exists in every cell within the human body and this, along with its role in the development of proteins, are the reasons why mRNA therapies have such potential in treating many diseases.

RNA 52

RNA Protein Vaccination Vaccine 52

Drug Discovery World

NOVEMBER 18, 2022

It states that whilst some antibiotic prescribing can be “appropriate when risks for related bacterial or fungal infections are unknown,” this level of high prescribing can “put patients at risk for side effects and create a pathway for resistance to develop and spread.” . Still, there are positive developments occurring within the sector.

Bacteria 52

Bacteria Drugs Development Research 52

Drug Discovery World

MAY 4, 2023

The magic bullet was the drug, while the specific mark it would reach in the syphilis causing bacteria to eliminate the disease was the drug target. The drug target for Penicillin is a protein that helps bacteria to synthesise its cell wall. Salvarsan was soon overtaken by the Penicillin antibiotics.

Medicine 52

Medicine Protein Drugs Bioassay 52

The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens. Open channel assays may include IVD assays, also as routine lab developed tests (LDTs).

Marketing 52

Marketing In-Vitro DNA Bacteria 52

XTalks

DECEMBER 24, 2020

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. Most antibody drugs and vaccines have been developed to target parts of the spike protein. Pandemic Efforts.

Life Science 111

Life Science Vaccination Vaccine Gene 111

The Pharma Data

OCTOBER 14, 2020

Priothera will use the funds to progress the clinical development of mocravimod, a modulator of sphingosine 1 phosphate (S1P) receptors, to enhance the curative potential of allogeneic hematopoietic stem cell transplantation (HSCT) for treating AML. ERS Genomics – Ireland’s ERS Genomics signed an agreement with FASMAC Co.,

Clinical Trials 52

Clinical Trials Clinical Trials Manufacturing Trials 52