Scienmag

FEBRUARY 23, 2021

Scientists discover complex and dynamic bacterial ecosystem in human breast milk using genomic technology pioneered for the International Space Station Credit: Emmanuel Gonzalez et al.

Bacteria 52

Bacteria Genome Genomics Scientist 52

Drug Discovery World

OCTOBER 18, 2022

The researchers also found that Dynobactin kills Gram-negative bacteria, which include many dangerous and resistant pathogens. . The search for antibiotics against this group of bacteria is far from trivial,” said Hiller. Peptides encoded in bacterial genome. And these peptides are encoded in the bacterial genome. .

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Bacteria Genome Genomics Gene 94

Scienmag

JUNE 21, 2022

Peer-reviewed / Observational study / People Largest genome sequencing study of S. Typhi – the bacteria that causes Typhoid fever – charts the emergence and spread of antibiotic-resistant strains. Typhi genomes – mostly from South Asia – shows resistant strains have spread between countries at least 197 times in […].

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Bacteria Genome Genomics 40

Scienmag

JUNE 21, 2022

HOUSTON – (June 21, 2022) – It’s a given that certain bacteria and viruses can cause illness and disease, but the real culprits are the sequences of concern that lie within the genomes of these microbes. Credit: Treangen Lab/Rice University HOUSTON – (June 21, 2022) – It’s a given that certain bacteria and viruses can […].

DNA 62

DNA Bacteria Genome Genomics 62

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry CRISPR nuclease is a key innovation area in pharmaceutical development CRISPR, which refers to clustered regularly interspaced short palindromic repeats, are bacteriophage-derived DNA sequences that had previously infected the prokaryote and are found in the genomes of bacteria and archaea.

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In-Vivo Genome Genomics Gene Editing 162

Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

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Bacteria Drugs Gene Immune Response 52

STAT News

SEPTEMBER 30, 2022

The shortlist includes researchers who elucidated how cells make energy, those who discovered the chemical chatter of bacteria, many of the brilliant minds who shepherded us into the “ era of the genome ,” and most prominently, the pioneers behind the mRNA Covid vaccines. Read the rest…

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Bacteria Genome Genomics Vaccination 124

BioTech 365

MARCH 16, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists reveal new mechanism of xenogeneic silencing in bacteria.Lateral gene transfer (LGT) plays a prominent role in the genome evolution and environmental adaptation of prokaryotes.

Scientist 40

Scientist Bacteria Genome Genomics 40

Scienmag

OCTOBER 1, 2020

Work allows genomic monitoring for epidemic strains of Vibrio cholerae bacteria The evolution of epidemic and endemic strains of the cholera-causing bacterium Vibrio cholerae in Argentina has been mapped in detail by researchers at the Wellcome Sanger Institute, the London School of Hygiene and Tropical Medicine, the University of Cambridge and the (..)

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Bacterium Bacteria Genome Genomics 75

Delveinsight

JANUARY 28, 2021

Gut Bacteria proffer insight into molecules protective against asthma and COVID-19. The researchers began by transplanting gut bacteria from an immune-deficient mouse model into normal mice and observing the animals’ immune systems.

Bacteria 52

Bacteria Trials Drugs Clinical Trials 52

The Pharma Data

MAY 22, 2023

WHO launches global network to detect and prevent infectious disease threats WHO and partners are launching a global network to help protect people from infectious disease threats through the power of pathogen genomics. COVID-19 highlighted the critical role pathogen genomics plays in responding to pandemic threats.

Genome 52

Genome Genomics Bioinformatics Bacteria 52

Scienmag

OCTOBER 6, 2021

Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. Credit: María Lluch/CRG Researchers at […].

Medicine 40

Medicine Bacteria Genome Genomics 40

Scienmag

JUNE 7, 2021

Travellers abroad may pick up bacteria and other vectors containing genes conferring antimicrobial resistance which remain in the gut when returning to their home country, according to a study published in Genome Medicine.

Gene 40

Gene Bacteria Genome Genomics 40

pharmaphorum

MARCH 7, 2022

The approach combines phenotypic screening, proteomics, and genomics-based technologies with machine learning-powered analysis of data, avoiding the use of standard growth inhibition assays which can be slow and may miss potentially promising mechanisms.

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Bacteria Drugs Genome Genomics 137

The Pharma Data

DECEMBER 13, 2020

Food and Drug Administration (FDA) approved a first-of-its-kind intentional genomic alteration (IGA) in a line of domestic pigs, referred to as GalSafe pigs, which may be used for food or human therapeutics. SILVER SPRING, Md. , 14, 2020 /PRNewswire/ — Today, the U.S.

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FDA Approval Genome Genomics Production 52

Drug Discovery World

JANUARY 23, 2024

For example, enzymes sourced from bacteria living around hydrothermal vents have been used to support the polymerase chain reaction, the test used for Covid-19 detection. The ocean’s microbes represent the earliest lifeforms on Earth, making them important to study, not only for the evolution of life, but also for biotechnology.

DNA 103

DNA Drugs Gene Scientist 103

Drug Discovery World

FEBRUARY 8, 2024

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing.

Gene Therapy 59

Gene Therapy Gene Bioinformatics Life Science 59

Drug Discovery World

JULY 29, 2022

But with hundreds of bacterial species populating our gastrointestinal tract, it’s a daunting task to pinpoint which molecules made by which bacteria affect which biological processes—and how they do so. Such knowledge is essential for learning how to manipulate gut bacteria to treat or prevent illness.

Bacterium 52

Bacterium Research Bacteria Immune Response 52

Drug Discovery World

OCTOBER 3, 2023

This is largely due to their highly stable Inverted Terminal Repeat (ITR) regions, as this secondary structure is prone to deletions during propagation in bacteria and cannot be read by standard Sanger sequencing.

Gene Therapy 52

Gene Therapy Gene Life Science Bioinformatics 52

XTalks

MARCH 10, 2022

As the leader in genomic sequencing, Clear Labs helps its clients better understand and manage pathogens, from foodborne illnesses to SARS-CoV2. Salmonella , for example, has more than 2,400 types of the bacteria. Xtalks spoke to Sasan Amini, founder and CEO of Clear Labs, to find out more about the evolving food safety standards. .

Manufacturing 98

Manufacturing Genome Genomics Contamination 98

Drug Discovery World

FEBRUARY 6, 2024

Verge Genomics’ potential amyotrophic lateral sclerosis (ALS) treatment VRG50635 is one of the first drugs to enter clinical trials that was entirely discovered and developed using an AI-enabled platform 6. Automation is also being applied to genomics sample preparation, an area that requires particular robustness and scalability.

Marketing 69

Marketing Medicine Genome Genomics 69

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. I saw this, in particular, with the finishing of the human genome,” says Charlie. “At In reality, finishing the human genome was the first step of what is a long journey.”.

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Genome Genomics Medicine Gene 117

XTalks

NOVEMBER 3, 2023

CRISPR works as genetic scissors to edit parts of the genome. The CRISPR-Cas9 gene editing system was first discovered to be endogenous in bacteria. The companies used data from the 1,000 Genomes Project but from that, only 61 datasets made the cut to encompass the ideal patient population. “I

Gene Therapy 59

Gene Therapy Gene Gene Editing In-Vivo 59

The Pharma Data

JULY 11, 2021

We are talking about the microbiome – the vast collection of bacteria in the human gut. The microbiome has been the focus of research for 20 years – ever since a new technique made it possible to analyse these bacteria quickly and precisely: high-throughput sequencing. The immune system is mentioned particularly frequently.

Bacteria 52

Bacteria Genetics Regulation Scientist 52

Drug Discovery World

MAY 6, 2024

Mazzetti and Schneider give the example of T3 Pharmaceuticals, a University of Basel spin-off that developed a proprietary cancer therapy platform based on regulating and harnessing the natural behaviours of live bacteria. This knowledge base will accelerate the sector and encourage new companies.

Drugs 59

Drugs Life Science Gene Editing Gene 59

pharmaphorum

NOVEMBER 10, 2021

Success, then, will rely on an integrated response that focuses on surveillance, stewardship, and intervention accessibility across the spectrum of human, animal, and environmental health, said the report, which was commissioned to assess the progress of the 2014 National Strategy for Combating Antibiotic-Resistant Bacteria. Surveillance.

Medicine 104

Medicine Genome Genomics Genotype 104

Scienmag

MAY 27, 2021

Credit: LIU Yang Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed a technique to sort and sequence the genome of bacteria in soil one bacterial cell at a time, while also identifying what its function is in the soil environment. […]. (..)

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Bacteria Development Research Genome 67

The Pharma Data

OCTOBER 19, 2020

By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through the Caris Molecular Intelligence® platform, physicians from Winship will be able to further prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

XTalks

DECEMBER 14, 2022

The CRISPR-Cas9 gene editing system uses a programmable single guide RNA sequence (sgRNA) to find and bind to specific regions of DNA and the Cas9 nuclease induces double strand breaks at these target regions of the genome. Integrases are used by viruses called bacteriophages to insert their genetic material into bacteria.

Gene Editing 98

Gene Editing DNA Gene Gene Sequencing 98

Drug Discovery World

JULY 26, 2023

With 100-fold the number of genes in the human genome 1 , this microbial collection is a rich genetic signature of clinical significance that we have only recently gained the tools to explore. Genome editing tools such as CRISPR may be employed to create “live biotherapeutics” (drugs composed of living bacteria).

Medicine 52

Medicine Genome Genomics Bioinformatics 52

Pharmaceutical Technology

FEBRUARY 26, 2023

The idea behind these treatments relies on altering the gut microbiome by designing therapeutics that contain bacteria derived from donated stool samples. Although research here is about 20 years old, it remains new compared to other areas like genomics, says Gilbert. Vedanta is a subsidiary of Puretech Health.

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Bacteria Trials Research Medicine 278

The Pharma Data

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell , could have implications for gene editing therapies as well. In bacteria with unaltered tracr-L, levels of CRISPR-related genes were low. The authors found that tracr-L redirects Cas9 in S.

Bacteria 52

Bacteria Gene Editing Research RNA 52

XTalks

FEBRUARY 11, 2021

The Human Genome Project recently marked 20 years since the publication of the first full sets of human genomic sequences, an endeavor that spanned well over a decade. Today, new next-generation sequencing technologies allow for the sequencing of complex genomes within just a day or two.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

MAY 2, 2023

In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. In the event of an attack from similar bacteriophages, the bacteria can recognise these segments and use this to discern and cleave the viral DNA, which disrupts the viral gene function.

Genome 52

Genome Genomics Gene DNA 52

The Pharma Data

DECEMBER 31, 2020

New Class of Antibiotic Works Against Range of Bacteria. They focused on a metabolic pathway essential for bacteria but absent in humans, called methyl-D-erythritol phosphate (MEP) or non-mevalonate pathway, which is responsible for biosynthesis of isoprenoids. Isoprenoids are required for cell survival in most pathogenic bacteria.

Antibody 52

Antibody Research Bacteria Genetics 52

Drug Discovery World

AUGUST 10, 2022

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. If the gene does not integrate into the genome, the cell will not become a CAR T cell. National Institutes of Health researcher Ping Jin, Ph.D.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

Drug Discovery World

OCTOBER 4, 2022

Fischbach, who is an Associate Professor of Bioengineering and of Microbiology and Immunology, and others saw one solution: Build a microbiome from scratch by growing individually and then mixing its constituent bacteria. They introduced hCom1 to mice that are carefully designed to have no bacteria present. Building the ark.

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Research Bacteria Scientist Bacterium 52