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Engineering an “invisible cloak” for bacteria to deliver drugs to tumors

The Pharma Data

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Sheng Professor of Biomedical Engineering. Using Bacteria For Therapy.

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MBL team discovers new DNA modification system in animals, captured from bacteria more than 60 MYA

Scienmag

— Your DNA holds the blueprint to build your body, but it’s a living document: Adjustments to the design can be made by epigenetic marks. — Your DNA holds the blueprint to build your body, but it’s a living document: Adjustments to the […]. WOODS HOLE, Mass. Shribak and I. Yushenova WOODS HOLE, Mass.

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Regulating the ribosomal RNA production line

Scienmag

coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].

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Global advances in synthetic biology

Drug Discovery World

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

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CRISPR Therapeutics begins natural killer cell cancer tie-up with Nkarta

pharmaphorum

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of the gene editing technology and has refined it to the point where it can be used to accurately edit DNA to correct genetic conditions or modify cells to fight disease.

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Could Fluoride be the Solution to Antibiotic Resistance? A New Study Weighs In

The Pharma Data

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. “Essentially, what Justin did was to create a series of DNA instructions you can give to cells that will enable them to survive when fluoride is around,” said O’Malley.

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

Researchers from the University of Oslo, University of Chicago Pritzker School of Medicine, and Insilico Medicine used an AI target discovery engine to analyse transcriptomic data to identify dual targets for cancer and ageing 5. Digital tech is also helping researchers to find target candidates for some of the most challenging disease areas.