XTalks

FEBRUARY 25, 2022

There has been increasing awareness around the need for improving inclusion and diversity in clinical trials. As such, there has been a growing emphasis on efforts to achieve better and more accurate representations of minority and underrepresented populations like Black people in clinical studies.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Research 52

XTalks

JUNE 8, 2021

Novartis’ Zolgensma (onasemnogene abeparvovec) gene therapy has been making significant strides as of late, including dosing of the first Spinal Muscular Atrophy (SMA) patient with the treatment in the UK last week. SMA is caused by mutations in the survival motor neuron 1 ( SMN1) gene, which along with the SMN2 gene, encode the SMN protein.

Gene Therapy 110

Gene Therapy Gene Protein Trials 110

pharmaphorum

JANUARY 26, 2021

Under the leadership of CEO Vas Narasimhan, who took over in 2018, the company has focused on using digital technology to engage with both patients and doctors. Marie-France Tschudin, president of Novartis’s pharmaceuticals business, said digital technology had helped to improve productivity and its interactions with doctors.

Doctors 111

Doctors Doctor Sales Clinical Trials 111

pharmaphorum

SEPTEMBER 21, 2021

Global Gene’s Craig Martin introduces a new patient identification initiative that strives to improve diagnosis and access to clinical trials for all patients with rare CNS conditions. Doctors are often unfamiliar with these conditions. Less than 5% of the more than 7,000 rare diseases have approved treatments.

Gene Therapy 90

Gene Therapy Gene Clinical Trials Clinical Trials 90

Advarra

MARCH 10, 2023

hindering progress on SCD – there is also a lack of clinical trials and research. Diversity in Clinical Trials and SCD As many clinical trials in the U.S. One reason for recruitment obstacles is generational fear of clinical trials due to their history.

Clinical Trials 98

Clinical Trials Clinical Trials Trials Doctors 98

Drug Discovery World

AUGUST 16, 2023

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. “Our findings paint a complex picture – with many, dynamic factors driving how tumours respond to treatment.”

Genetics 52

Genetics Gene Hormones RNA 52

Velocity Clinical Research

OCTOBER 4, 2023

Velocity Clinical Research, the leading multi-specialty clinical sites business, announced it is opening greenfield clinical research sites in Bristol, Leicester, and Romford, demonstrating the company’s commitment to the U.K. The sites launch at a time when clinical trial activity in the U.K.

Clinical Research 52

Clinical Research Research Clinical Trials Clinical Trials 52

XTalks

MAY 17, 2024

Dr. Philipson’s transition to the biotech sector began with a position at UK-based biotech Trizell, where his efforts culminated in a gene therapy FDA submission for bladder cancer. The company also has a Phase II trial looking at setanaxib in patients with head and neck cancer. Can they do it?

Development 52

Development Drugs Clinical Trials Clinical Trials 52

Pharmaceutical Technology

AUGUST 12, 2022

Dr Merit Cudkowicz, a co-principal investigator in Amylyx’s clinical trials, says patients and investigators are pushing for an approval given the unmet need for therapies. “By Another objective deals with improving trial infrastructure and encouraging enrolment on decentralised clinical trials (DCT).

Research 246

Research Gene Therapy Drugs Trials 246

Drug Discovery World

DECEMBER 18, 2023

Digital biomarkers promise to transform preventive medicine and clinical trials, but also raise issues of security, regulation and potential disparities in access. Deepika Khedekar, Clinical Trial Lead at IQVIA, provides an overview of the pros and cons, and suggests a possible solution.

Clinical Research 59

Clinical Research Research Clinical Trials Clinical Trials 59

Pharmaceutical Technology

JULY 28, 2022

Roche’s Susvimo (ranibizumab sustained release formulation) follows a similar theme; patients who are implanted with Susvimo are expected to visit their doctor only twice a year to have the implant refilled so that the medicine can be delivered to their eyes continuously. The therapy received FDA approval in October last year.

Marketing 130

Marketing Gene Therapy FDA Approval Doctors 130

pharmaphorum

OCTOBER 21, 2021

Many are still predicting multibillion-dollar sales for the drug, albeit with a longer runway, despite reservations about its clinical efficacy among doctors and payers. Analysts meanwhile have suggested that Aduhelm may start to pick up momentum if that review is positive.

Sales 122

Sales Doctors Doctor Gene Therapy 122

Olympian Clinical Research

JUNE 10, 2022

If you are experiencing any of the above symptoms, it is important to consult with your doctor or dermatologist for an accurate diagnosis. This condition occurs when a gene variation causes the skin to become dry and irritated. Talk to your doctor about prescription medications that may help relieve itching and inflammation.

Allergies 98

Allergies Clinical Trials Clinical Trials Clinical Research 98

Camargo

JULY 30, 2021

In 1981, I got my doctorate degree in Clinical Pharmacology, but more importantly, my research was heavily involved in neonatal medicine, developing drugs there. That has to do a lot with the work in gene therapy and rare disease and the ultra-rare space because there are 7,000 rare diseases that have been identified.

Clinical Research 226

Clinical Research Research Gene Therapy Gene 226

pharmaphorum

AUGUST 13, 2020

NS Pharma’s Viltepso (viltolarsen) has been approved in patients who have confirmed mutation of the DMD gene that is amenable to exon 53 skipping. The DMD gene is made up of 79 exons, and mutations in that code can result in a deficiency in dystrophin which is responsible for the muscle wasting in DMD.

FDA Approval 52

FDA Approval Drugs Gene Trials 52

Bioengineer

JULY 22, 2021

The scientists now call for clinical trials to begin imminently, in which an already approved class of drugs called “EZH2 inhibitors” can be assessed. How to target this cancer-causing gene with a drug that slows cancer cell growth. Key findings and implications.

Genetics 52

Genetics Drugs Clinical Trials Clinical Trials 52

XTalks

APRIL 6, 2022

Register for this webinar to get an overview of the role of long non-protein coding RNAs (lncRNAs) in gene regulations. Therefore, these patients could have a clinical benefit from further treatment or participation in a clinical trial. Live and On-Demand: Thursday, April 21, 2022, at 11am EDT (4pm BST/UK).

DNA 105

DNA In-Vitro Doctors Doctor 105

XTalks

SEPTEMBER 22, 2020

“Helping people understand and manage their heart health has always been a priority for Fitbit, and our new ECG app is designed for those users who want to assess themselves in the moment and review the reading later with their doctor,” Eric Friedman, Fitbit co-founder and CTO said in a statement.

Gene 107

Gene Doctors Doctor Clinical Trials 107

pharmaphorum

FEBRUARY 28, 2022

Many of the small challenges that face individual doctors and patients in seeking to find a solution for a rare disease also contribute to the difficulty of researching and developing an effective treatment. Once diagnosed, only 5% of rare diseases actually have an effective treatment. The outlook for rare disease R&D. Work to be done.

Gene Therapy 104

Gene Therapy Gene Development Medicine 104

XTalks

DECEMBER 20, 2023

Originally launched in 2020 to encourage doctor visits during the pandemic, the BMS-Pfizer campaign, which also covers deep vein thrombosis and pulmonary embolism, aligned with the growing sales of their anticoagulant, Eliquis (apixaban). Read the full article for more insights into the dynamic field of life science consulting.

Life Science 59

Life Science Clinical Trials Clinical Trials FDA Approval 59

pharmaphorum

APRIL 11, 2022

As an oncology trained medical doctor who practiced in the UK NHS for 10 years, I have seen the benefits first-hand, as patients live longer lives, free from symptoms, and are able to return to work. Medicines and vaccines are among the most powerful interventions that can help improve quality of life for people across the world.

Medicine 116

Medicine Clinical Trials Clinical Trials Development 116

Bioengineer

JULY 23, 2021

” Jain’s team in College Station for this research includes postdoctoral researcher Dr. Biswajit Saha and doctoral students Jim Tronolone and Tanmay Mathur. Gang Bao, a gene editing expert from Rice University. Their research involving the OTME-Chip was recently published in the journal Science Advances. ” ###.

Engineer 52

Engineer Gene Editing Clinical Trials Clinical Trials 52

The Pharma Data

MARCH 30, 2021

Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for atogepant, an investigational orally administered calcitonin gene-related peptide (CGRP) receptor antagonist (gepant), for the preventive treatment of migraine in adults who meet criteria for episodic migraine.

Botox 52

Botox Drugs Doctors Doctor 52

pharmaphorum

APRIL 16, 2021

Longer term challenges, such as the slowdown of HTA outputs, delays to clinical trials and regulatory submission, and the coming impact of economic crisis on medicines budgets will further challenge launch prognosis in the coming years. Once approved, launches do not necessarily become immediately commercially available. “For

Sales 95

Sales Marketing Medicine Doctors 95

The Pharma Data

MAY 9, 2022

Investigators discovered meningiomas can be divided into molecular subgroups with different clinical outcomes and recurrence rates. Currently, after surgery, doctors examine a specimen of a tumor under a microscope and grade it one, two or three in its aggressiveness.

Drugs 52

Drugs Scientist DNA Genetics 52

pharmaphorum

MAY 10, 2022

And those doctors have been born with TikTok on the mind and they will not go with the communication from the previous millennium. Hutnik gave an example of her work with Spark Therapeutics to develop a product to teach haemophilia patients about gene therapy. The first Gen Z HCPs are reaching the practice.

Marketing 98

Marketing Sales Gene Therapy Branding 98

Drug Discovery World

APRIL 14, 2023

He is being recognised for his revolutionary contributions to developing the first gene-edited cell-based therapy for cancer that involves the genetic re-engineering of a patient’s own T cells to combat their disease, and for demonstrating that adoptive T-cell therapy can induce remission and in some cases cure patients with advanced cancer.

Genetics 52

Genetics Research Medicine Clinical Research 52

pharmaphorum

SEPTEMBER 12, 2022

Across LabCorp , we innovate through science and technology, with access to approximately 2,500 [doctors] and PhDs and over 700 patients. Cancer cells and tumours behave differently than normal cells and have changes in their genes that make them different from an individual’s normal cells. Navigating barriers to access.

Genome 106

Genome Genomics Clinical Trials Clinical Trials 106

WCG Clinical

JUNE 4, 2024

We started, you know, experimenting with different gene therapies and antisense therapies. Doctors actually like to write. One of the things it does, it would allow regulators to compare the trial results of a clinical trial to something. We developed our own mouse models and cell lines. All of us have MyChart.

Research 52

Research Clinical Trials Clinical Trials Doctors 52

WCG Clinical

SEPTEMBER 26, 2023

Listen and Subscribe: Apple PodCASTs Spotify Google PoDCASTS About this episode: Join WCG Talks Trials podcast host Kelly Fitzgerald, PhD, in a riveting dialogue with guest expert Currien MacDonald, MD, as they unravel the nuances of “Psychedelics in Research: Ethical and Medical Perspectives.” We’ve never seen before.

Research 59

Research Drugs Trials Clinical Research 59

pharmaphorum

OCTOBER 27, 2020

Novartis’ pharmaceutical sales recovered in the third quarter of this year after an earlier COVID-19 decline, as new drugs like gene therapy Zolgensma gathered pace. . Correcting for currency fluctuations, net sales were flat at $12.3 Sales are expected to rise by a mid-single digit percentage in 2020 as a whole.

Sales 98

Sales Gene Therapy Dermatology Gene 98

World of DTC Marketing

JANUARY 31, 2021

I have been recruited by these companies who promise huge payouts when they are acquired if their drug shows promise in clinical trials. Ex vivo (where cells are genetically modified outside the body) cell and gene therapies have generated considerable excitement on their potential to cure previously incurable diseases.

In-Vivo 187

In-Vivo Generic Drugs Gene Therapy Drugs 187

XTalks

JUNE 19, 2023

Pfizer acquired Nurtec ODT and five preclinical calcitonin gene-related peptide (CGRP) receptor antagonist candidates from Biohaven’s CGRP inhibitor portfolio last year. Talk to a doctor about Nurtec ODT.” How Does Nurtec ODT (Rimegepant) Work?

FDA Approval 97

FDA Approval Trials Doctors Doctor 97

The Pharma Data

SEPTEMBER 8, 2021

Real-World Evidence for Control of Patients With Chronic Migraine Who Received Calcitonin Gene?Related Patients treated for overactive bladder: In clinical trials, 36 of the 552 patients had to self-catheterize for urinary retention following treatment with BOTOX ® compared to 2 of the 542 treated with placebo.

Botox 52

Botox Doctors Doctor Medicine 52

The Pharma Data

DECEMBER 3, 2020

Clinical Trials. Targeted Augmentation of Nuclear Gene Output (TANGO) of SCN1A Reduces Seizures and Rescues Parvalbumin Positive Interneuron Firing Frequency in a Mouse Model of Dravet Syndrome. protein expression by leveraging the non-mutant (wild-type) copy of the SCN1A gene to restore physiological Na V 1.1

Medicine 52

Medicine Genetics Clinical Trials Clinical Trials 52

Pharmaceutical Technology

FEBRUARY 1, 2023

However, subsequent RSV drugs, like Medimmune’s motavizumab, failed in clinical trials. This would be preferable for patients as doctors must administer Synagis to patients five times per month during peak RSV season.

Vaccination 162

Vaccination Vaccine Antibody FDA Approval 162

Pharma Marketing Network

JANUARY 20, 2021

Assuming these findings are replicated in clinical trials, this vaccine, with its more-appealing route of administration and convenient (refrigerator) storage requirements could make an important contribution to containing the disease.

Vaccination 52

Vaccination Vaccine In-Vivo Genetics 52