Bioengineer

JULY 22, 2021

Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its effects to slow cancer cell growth with a targeted drug.

Genetics 52

Genetics Drugs Clinical Trials Clinical Trials 52

Drug Discovery World

OCTOBER 18, 2023

4 Unfortunately, many AAV-based gene therapies fail during clinical trials, despite them appearing safe and efficacious in preclinical studies. Consequently, researchers are progressing treatments that are unlikely to succeed at clinical trials, while rejecting potentially powerful ones.

Gene Therapy 64

Gene Therapy Gene Clinical Trials Clinical Trials 64

XTalks

AUGUST 21, 2023

“For the first time, doctors have an approved medicine available to them, shown to reduce the formation of new, abnormal bone growth, known as heterotopic ossification (HO), which causes debilitating mobility challenges and has a devastating impact on the lives of people with FOP.”

Drugs 98

Drugs FDA Approval Genetics Clinical Trials 98

pharmaphorum

SEPTEMBER 21, 2021

Global Gene’s Craig Martin introduces a new patient identification initiative that strives to improve diagnosis and access to clinical trials for all patients with rare CNS conditions. Doctors are often unfamiliar with these conditions. Rare diseases impact more than 30 million Americans, and 400 million people around the globe.

Gene Therapy 76

Gene Therapy Gene Clinical Trials Clinical Trials 76

ACRP blog

OCTOBER 6, 2022

population, but comprise over 90% of the population in clinical trials. The total percentage of minority inclusion from all clinical trials in the United States during the last 25 years was just 3.95%. [1]. Study sites may also add any of their clinical trials at no cost. of the U.S. 1] Manuel A.

Research 98

Research Clinical Trials Clinical Trials Trials 98

STAT News

MARCH 6, 2023

Still, when doctors told her last year that the cancer was growing despite two operations, radiation therapy, and a fifth regimen of chemotherapy, the retired business-meeting facilitator decided to do something unorthodox: spend $83,000 out of pocket on an unproven experimental cancer vaccine.

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Vaccination Vaccine Drugs Clinical Trials 98

Olympian Clinical Research

JUNE 2, 2021

One of the most frustrating things about atopic dermatitis is that doctors still don’t know exactly what causes the condition, which means that most treatments are centered around symptom mitigation rather than addressing the root cause. Eczema Clinical Trials In Tampa & Largo. What Causes Atopic Dermatitis?

Clinical Trials 52

Clinical Trials Clinical Trials Clinical Research Trials 52

The Pharma Data

DECEMBER 11, 2020

And even when Black people with AML have the same access to treatment as white patients, their survival is shorter — something genetic differences might explain. But even when patients of both races received the same treatments, Black patients’ outcomes were worse, clinical trial data showed.

Genetics 52

Genetics Clinical Trials Clinical Trials Genetic Analysis 52

The Pharma Data

AUGUST 16, 2021

If this genetic material is further replicated, defective RNA copies are produced and the pathogen can no longer spread. Molnupiravir is currently being tested in clinical trials. Based on preliminary clinical trials, the compound promises to be highly effective against Sars-CoV-2.

RNA 52

RNA Drugs Genome Genomics 52

pharmaphorum

SEPTEMBER 17, 2020

The vaccine is based on a weakened virus that causes cold symptoms in chimpanzee, which causes an immune respone with genetic material coding for the spike protein found on the surface of the coronavirus. According to the World Health Organization, AZ’s vaccine is the most advanced in a list of 36 vaccines in clinical trials for COVID-19.

Vaccination 105

Vaccination Vaccine Trials Doctors 105

pharmaphorum

DECEMBER 21, 2020

As it’s just a messenger molecule, it does not affect the body’s own genetic code when it is injected as a vaccine – but what it does do is instruct cells to code for copies of a certain protein. They are very good doctors, scientists and entrepreneurs. He told pharmaphorum: “They are very good doctors, scientists and entrepreneurs.

Vaccination 93

Vaccination Vaccine Doctors Doctor 93

XTalks

APRIL 6, 2022

Therefore, these patients could have a clinical benefit from further treatment or participation in a clinical trial. If that happens, it is a big setback for patients and the doctors treating them,” said Dr. Rosenfeld in a news release by Cancer Research UK.

DNA 105

DNA In-Vitro Doctors Doctor 105

XTalks

MAY 20, 2022

A clinical scientist runs experiments on biological samples — cells, tissues, blood and body fluids to identify infections and biomarkers. Doctors and physicians rely on the results provided by a clinical scientist to make an accurate prognosis, diagnosis and assessment for a patient’s treatment plan. Genetic Science.

Scientist 105

Scientist Life Science Clinical Research Doctors 105

pharmaphorum

AUGUST 1, 2022

Sarepta reported updated clinical trial results with the one-shot therapy in July which bolstered the data for SRP-9001 (delandistrogene moxeparvovec) for efficacy and durability, but also raised a concern about its safety after a serious case of myocarditis was seen in one of 38 patients enrolled in its ENDEAVOR study.

Gene Therapy 105

Gene Therapy Gene Trials Genetics 105

The Pharma Data

DECEMBER 17, 2020

Dr. Lisa Forbes — his doctor and co-author of a letter describing his case in the Oct. This patient had a genetic mutation that ruxolitinib is known to work on. Forbes said it’s not clear if other people with type 1 diabetes also have this specific genetic mutation. WEDNESDAY, Oct.

Insulin 52

Insulin Genetics Doctors Doctor 52

Olympian Clinical Research

FEBRUARY 17, 2022

However, genetic abnormalities or other health problems may be involved in the condition. When diagnosing PN, a doctor may perform a skin biopsy to look for signs of the condition, such as thickened skin and inflammation. If this is the case, clinical research studies may be a good option for you. . The Itch-Scratch Cycle.

Clinical Trials 52

Clinical Trials Clinical Trials Clinical Research Trials 52

Olympian Clinical Research

NOVEMBER 6, 2023

While the exact cause is unknown, factors like genetics, inflammation, and hormones play a role. Apply topical medication as prescribed by your doctor if needed. Apply a topical or oral anti-inflammatory medication as prescribed by your doctor. You can contribute to this essential work by participating in our clinical trials.

Hormones 52

Hormones Doctors Doctor Clinical Trials 52

XTalks

DECEMBER 20, 2023

The companies include a diverse range engaged in innovative approaches in areas like oncology, genetic medicines, inflammatory diseases, dermatology and cardiorenal therapy. 9. 10 Trends and Statistics for Clinical Trials in 2023 Several key trends in clinical trials have been shaping the landscape of the field this year.

Life Science 59

Life Science Clinical Trials Clinical Trials FDA Approval 59

XTalks

SEPTEMBER 22, 2020

“Helping people understand and manage their heart health has always been a priority for Fitbit, and our new ECG app is designed for those users who want to assess themselves in the moment and review the reading later with their doctor,” Eric Friedman, Fitbit co-founder and CTO said in a statement.

Gene 107

Gene Doctors Doctor Clinical Trials 107

pharmaphorum

SEPTEMBER 28, 2022

Minor variations in one’s genetic makeup can impact individual responses to medication. Understanding these differences across diverse populations can help doctors and HCPs determine what medication and dosage best fit a patient. ” All of Us is currently looking at ways to share its data with the for-profit sector.

Research 94

Research Medicine Clinical Trials Clinical Trials 94

The Pharma Data

MAY 9, 2022

Investigators discovered meningiomas can be divided into molecular subgroups with different clinical outcomes and recurrence rates. Currently, after surgery, doctors examine a specimen of a tumor under a microscope and grade it one, two or three in its aggressiveness. The paper was published today in Nature Genetics.

Drugs 52

Drugs Scientist DNA Genetics 52

pharmaphorum

OCTOBER 6, 2022

By reducing the disease to its key components, a computer-readable network of disease markers was characterised using genetic, biomarker, and clinical data; the model was also populated with ‘disease vs control’ data. Not only does this make drug discovery more efficient, but it is also less resource intensive. The future of in silico.

In-Vivo 98

In-Vivo Research Genetics Drugs 98

pharmaphorum

AUGUST 13, 2020

It’s bad form to compare performance of drugs in separate clinical trials, but results suggest that Viltepso helps patients produce more dystrophin than Sarepta’s rival Vyondys 53 (golodirsen). Viltepso was evaluated in two clinical studies with a total of 32 patients, all of whom were male and had genetically confirmed DMD.

FDA Approval 52

FDA Approval Drugs Gene Trials 52

XTalks

JUNE 8, 2021

In addition, recent data from a Phase I trial has shown ‘remarkable’ long-term results of the gene therapy in children with the disease. The prevalence of SMA is about one in 10,000 children, and one in 54 people carry the SM1 genetic mutation; two carriers have a 25 percent chance of having a child with SMA.

Gene Therapy 110

Gene Therapy Gene Protein Trials 110

Drug Discovery World

APRIL 14, 2023

He is being recognised for his revolutionary contributions to developing the first gene-edited cell-based therapy for cancer that involves the genetic re-engineering of a patient’s own T cells to combat their disease, and for demonstrating that adoptive T-cell therapy can induce remission and in some cases cure patients with advanced cancer.

Genetics 52

Genetics Research Medicine Clinical Research 52

Drug Discovery World

SEPTEMBER 5, 2022

Tumours (yellow) pervade the lungs of mice genetically prone to small cell lung cancer (left) on this computed tomography scan. We’re talking to a number of other groups about starting a Phase I clinical trial as soon as possible,” Mosammaparast said. Hindering this repair process makes the drug much more effective. .

Protein 52

Protein Drugs Medicine Research 52

Olympian Clinical Research

SEPTEMBER 16, 2021

Similar to a majority of autoimmune diseases, the cause is most likely genetic, but environmental triggers are required to initiate disease activity. . In addition, your child’s doctor will likely recommend an antihistamine , which is a kind of drug that treats allergies to help with itching. Contact Olympian Clinical Research .

Clinical Research 52

Clinical Research Allergies Development Doctors 52

pharmaphorum

FEBRUARY 28, 2022

Many of the small challenges that face individual doctors and patients in seeking to find a solution for a rare disease also contribute to the difficulty of researching and developing an effective treatment. Once diagnosed, only 5% of rare diseases actually have an effective treatment. The outlook for rare disease R&D.

Gene Therapy 98

Gene Therapy Gene Development Medicine 98

pharmaphorum

JANUARY 29, 2021

This has, of course, garnered immense excitement – Doctors Emmanuelle Charpentier and Jennifer Doudna were named winners of the Nobel Prize for chemistry in recognition of their discovery of CRISPR/Cas9 gene editing technology. And ultimately we will be able to add genetic influences to diseases that don’t have a genetic cause.

Gene Editing 145

Gene Editing Gene Gene Therapy In-Vivo 145

pharmaphorum

AUGUST 25, 2022

That was until my doctors stunned me with the news that I had cirrhosis caused by non-alcoholic steatohepatitis, or NASH, a severe form of fatty liver disease that often has few or no symptoms until very late stages. Obesity, diabetes, and genetics are the primary drivers, and COVID is about to make this exponentially worse.

Development 98

Development Drugs Trials Medicine 98

Bioengineer

JULY 23, 2021

. “By applying high-resolution imaging, advanced cell and molecular readouts and RNA sequencing methods leveraging the OTME-Chip, we discovered the actual genetic signaling pathways behind the blood cell triggered metastasis of ovarian cancer and a new drug strategy to stop this process.” ” ###.

Engineer 52

Engineer Gene Editing Clinical Trials Clinical Trials 52

pharmaphorum

JUNE 18, 2021

This mission saw him become a diplomat in the Middle East, a McKinsey consultant in Asia, and take on roles in international intelligence before realizing he could use his knowledge and skills in solving complex problems to crack one of healthcare’s greatest challenges—accelerating clinical trials. positioned to rise to the challenge.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Big Data 52

The Pharma Data

NOVEMBER 27, 2020

The hand-held testing device uses lateral flow – like a home pregnancy test – to detect the virus’s interaction with sugars around human cells, so that nurses, doctors and patients can all easily perform the test without any prior training and at any location. .

Vaccination 52

Vaccination Vaccine Immune Response Marketing 52

pharmaphorum

APRIL 8, 2021

COVID-19 has been a trial-by-fire showing just how quickly drugs and vaccines can be developed under the right circumstances – but there is much to do to ensure this progress is not lost, said speakers at WIRED Health 2021, including the CEOs of BioNTech and BenevolentAI. . In the UK we have world leading genetic sequencing capabilities.

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Development Drugs Vaccination Vaccine 82

pharmaphorum

SEPTEMBER 12, 2022

Across LabCorp , we innovate through science and technology, with access to approximately 2,500 [doctors] and PhDs and over 700 patients. Everyone’s genetic makeup differs, and each person’s cancer experience is unique to them – how cancer develops, how fast it spreads, which drugs it responds to, and more. Tailored oncology.

Genome 105

Genome Genomics Clinical Trials Clinical Trials 105

pharmaphorum

NOVEMBER 10, 2022

Elliott informed those in attendance that for the next five years, with about £5 billion in funding for pipelines across a network of research and institute centres in clinical trials, that the aim is for everyone to live a life free of cancer. And in the UK over 30% of clinical trials funded has one European partner at least.

Nurses 92

Nurses Research Clinical Trials Clinical Trials 92

The Pharma Data

NOVEMBER 18, 2020

The California company said that clinical trials showed 100% of patients were able to perform the Lucira test in about two minutes. Lab tests that look for the coronavirus’s genetic material using a technique called polymerase chain reaction (PCR) are still considered the gold standard for detecting the virus.

FDA Approval 52

FDA Approval Vaccination Vaccine Genetics 52