Scienmag

OCTOBER 4, 2020

CHICAGO – Researchers have identified genetic mutations that appear to protect women from severe bleeding after childbirth, a leading cause of maternal death. DNA, which carries genetic information in cells, contain biological instructions. A genetic mutation, which is a permanent […].

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The Pharma Data

NOVEMBER 19, 2020

MD, FAAP, Cincinnati Children’s Hospital, who will discuss genetic forms of hearing loss in children. Dr. John Greinwald is a tenured professor of Otolaryngology and Pediatrics with over 20 years of experience with a focus on the genetic causes and treatment of deafness. To register for the call, please click here. Disclaimer.

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Genetics Containment Genetic Disease Gene Therapy 52

Drug Discovery World

FEBRUARY 7, 2024

Astellas has submitted a supplemental new drug application (sNDA) in Japan for Padcev (enfortumab vedotin (genetical recombination)) with Keytruda (pembrolizumab (genetical recombination)) for the first-line treatment of advanced bladder cancer. The sNDA is based on results from the Phase III EV-302 clinical trial.

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Regulation Containment Genetics Clinical Trials 52

Scienmag

NOVEMBER 15, 2021

Cell biologists track this process by observing chromosomes—structures made of DNA that contain the genetic material of an organism. Cell division is an important process that underlies biological growth and repair. However, their analysis is still […].

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DNA Containment Genetics Research 83

Pharmaceutical Technology

FEBRUARY 15, 2023

The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule. The vaccine also contains other inactive ingredients such as cholesterol.

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Drug Discovery World

DECEMBER 20, 2023

Relatively little has been known about the genetics or biology of this metastatic site until now. BCLM genetically distinct from primary breast tumour For this study, researchers at the Breast Cancer Now Toby Robins Research Centre at the ICR analysed liquid biopsies, which contain circulating tumour DNA (ctDNA).

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Drug Discovery World

JANUARY 23, 2024

Moreover, the use of marine genetic resources in industrial processes yields an estimated $6 billion annually, a number that doubles every six years as more genes in ocean microbes are found.

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DNA Drugs Gene Scientist 103

The Pharma Data

DECEMBER 28, 2020

About Fulgent Genetics. Fulgent Genetics’ proprietary technology platform has created a broad, flexible test menu and the ability to continually expand and improve its proprietary genetic reference library while maintaining accessible pricing, high accuracy and competitive turnaround times. TEMPLE CITY, Calif.,

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Genetics Sales Gene Sequencing Marketing 52

Scienmag

FEBRUARY 19, 2021

Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells Credit: DGIST Despite our great progress in understanding various cellular mechanisms over the last decades, many of them remain unclear.

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Scienmag

MAY 7, 2021

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling […]. (..)

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DNA Regulation Genome Genomics 62

FDA Law Blog

DECEMBER 8, 2022

labeling of major food allergens in bulk foods, dietary supplements, protein-free ingredients, and foods produced through genetic engineering); and. Most notably, the draft guidance clarifies that the following food products are subject to the allergen labeling requirements: Bulk containers (e.g., Other technical labeling matters.

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Genetic Engineering Containment Cosmetics Protein 59

Advarra

OCTOBER 26, 2023

Controlled Environment and IP Containment The potential for a release, and the risk associated with a genetically engineered IP, are part of the IBC’s assessment purview under National Institutes of Health (NIH) Guidelines. The containment must then prevent spills or leaks if the IP is dropped. Size matters.

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Drug Discovery World

JULY 3, 2023

The OXEGENE dataset contains anonymised genotype data including disease stage and infertility status, from 1,000 surgically confirmed patients. There are currently no approved diagnostic biomarkers or cures for the disease. The post Endometriosis partners to discover personalised treatments appeared first on Drug Discovery World (DDW).

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Genetics Genotype Medicine Licensing 52

Pharmaceutical Technology

SEPTEMBER 20, 2022

The production of commercial dose non-sterile products such as tablets, capsules, ointments, creams, and powders is rising due to their growing global demand, attributed to increasing demand for anti-ageing products, hereditary factors, genetic mutations, exposure to harmful radiation, and rising geriatric population.

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Scienmag

JANUARY 18, 2022

The authors found that, whilst a low proportion of breastmilk contained COVID-19 genetic material, this did not translate into the presence of infectious replicating viral particles or lead to evidence of […].

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Containment Genetics Research 58

Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

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Genome Genomics RNA Protein 70

The Pharma Data

OCTOBER 20, 2020

$1 million in research funding to support PD GENEration, a first-of-its-kind national study offering free genetic testing and counseling for people with Parkinson’s disease (PD). 10-15% of people with Parkinson’s disease have a genetic form of the disease. CAMBRIDGE, Mass.

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Scienmag

JUNE 9, 2021

Credit: Kazan Federal University Homocysteine (HCY) is a sulfur-containing aminoacid, which attract more and more attention as the increase of homocysteine level associates with a number of pathological conditions. Hyperhomocysteinemia (hHCY) is an elevation of HCY level in plasma and develops due to genetic mutations of enzymes […].

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Containment Genetics Development Research 52

XTalks

MARCH 21, 2024

The products contain ingredients like bamboo fiber, pea protein and mushrooms. The study also highlights how genetically engineered microorganisms can inhibit the growth of foodborne pathogens. Additionally, the offerings have the distinctive “snap” of the outer casing and the savory smokiness of Oscar Mayer products.

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Advarra

AUGUST 31, 2022

Tools or special sharp containers to remove the needle and replace with a fresh and already capped needle. All potentially infectious sharps must be disposed of in a biohazard sharps container immediately after use without recapping. The container can be a rigid plastic container (e.g., The one-handed scoop technique.

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Production Biohazard Biohazard Containment 52

Drug Discovery World

APRIL 12, 2024

The top stories: Genetically engineered dendritic cells enhance lung cancer therapy A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response.

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Drug Discovery World

JULY 21, 2023

BioIVT has acquired PrecisionMed, a supplier of human biological material for genetics, drug discovery, and biomarker research and in vitro diagnostics. Its collection contains both normal and diseased CSF samples together with other matched biofluids, such as plasma, sera, and whole blood.

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Scienmag

SEPTEMBER 14, 2021

The term ‘DNA’ immediately calls to mind the double-stranded helix that contains all our genetic information. But the individual units of its two strands are pairs of molecules bonded with each other in a selective, complementary fashion.

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DNA Gene Containment Genetics 40

Medical Xpress

MAY 9, 2023

Leucine-rich repeats containing 4 (LRRC4)—a gene abundantly found in the brain and located on human chromosome 7q31–32—plays a pivotal role in memory formation, autism, spinal cord injury, as well as in determining the malignant potential, development, and progression of glioblastoma (GB), an aggressive cancer involving the brain and/or spinal cord. (..)

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Drug Discovery World

DECEMBER 5, 2022

Scientists have unlocked key insights into virus evolution, revealing new information that could help develop treatments for a wide variety of genetic diseases. . Some have even been successfully harnessed as gene therapy vectors for the treatment of genetic diseases. .

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Gene Therapy Gene Genetic Disease Genetics 52

Scienmag

MAY 18, 2021

(Boston)–Researchers from Boston University School of Medicine (BUSM) report the formation of human cells containing a green fluorescent protein or GFP (one of the most important proteins in biology and fluorescence imaging) genetically fused with two interferon stimulated genes (ISGs), namely Viperin and ISG15.

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Immune Response Reagent Research Protein 41

Scienmag

APRIL 23, 2021

Our cells, and those of animals, plants and fungi, contain compartments that produce chemical fuel. These compartments contain their own DNA, which stores instructions for important […].

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DNA Containment Research Genetics 89

FDA Law Blog

SEPTEMBER 29, 2022

Plaintiffs challenged the use of the term bioengineered (rather than GMO or genetically engineered), the limitation of the mandatory disclosure being required only if the food contains detectable modified genetic material and the options of using a QR code disclosure or a text message for the disclosure statement.

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Genetic Engineering Containment Genetics Regulation 59

Drug Discovery World

JANUARY 11, 2024

The team, led by University College London (UCL), King’s College London and Moderna scientists, found that mRNA could be used to correct a rare genetic liver disease known as argininosuccinic aciduria in a mouse model. mRNA contains instructions that direct the cells to make proteins.

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Pharmaceutical Technology

DECEMBER 12, 2022

It leverages the new D-Domain binder of Arcellx and contains autologous T cells genetically modified for targeting multiple myeloma. An investigational late-stage product candidate, CART-ddBCMA is being analysed in the Phase II iMMagine-1 clinical trial at present.

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Pharmaceutical Technology

MAY 24, 2023

It can correct several disease elements associated with PKD, a rare, monogenic red blood cell disorder caused by a mutation in the PKLR gene.

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Drug Discovery World

SEPTEMBER 14, 2023

Europe has one of the highest rates of bladder cancer in the world 1 , with more than 203,000 patients diagnosed in 2020 alone 2. 8 On August 29, Janssen submitted a supplemental New Drug Application (sNDA) to the FDA seeking full approval of erdafitinib in this indication based on Cohort 1 of the Phase III THOR study.

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Medical Xpress

MARCH 23, 2023

It contains all the information that our cells need to make proteins and other molecules vital for our development, growth and survival. DNA is our body's instruction manual.

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DNA Containment Protein Development 56

Drug Discovery World

JULY 10, 2023

This paid-for advertorial by Taconic appeared in DDW Volume 24 – Issue 3, Summer 2023 Overcoming challenges in model generation Genetically engineered mouse models are essential tools for biomedical research. Figure 1: Characterisation of chimeric founders for a genetically humanized allele. (A)

Genetics 52

Genetics Gene Editing Genetic Engineering In-Vitro 52

WCG Clinical

NOVEMBER 17, 2023

Although the NIH Guidelines were originally written with non-clinical laboratory research in mind, they also apply to human gene transfer (HGT) research, wherein rsNA or rsNA-containing products are administered to research participants. Since then, however, certain genetic engineering technologies (e.g.,

Genome 52

Genome Genomics Gene Editing Genetic Engineering 52

XTalks

MARCH 22, 2024

According to the EWG, about 95 percent of nonorganic strawberries, certain leafy greens (including spinach, kale, collard and mustard greens), grapes, peaches and pears contain detectable levels of pesticides. Children and farmworkers are among the most vulnerable, and exposure can lead to genetic damage and impaired neurodevelopment.

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Contamination Regulation Containment Genetics 109

Roots Analysis

FEBRUARY 26, 2024

Whether it was a common cold or a genetic disease, prayers and sacrifices to the gods were the only hope of a remedy at such times. It is possible that the legend of Big Foot may be based on an unfortunate person suffering from elephantiasis or gigantism or some other genetic predisposition that would have rendered him abnormal.

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