Scienmag

OCTOBER 7, 2020

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications DNA and RNA have been compared to “instruction manuals” containing the information needed for living “machines” to operate.

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RNA DNA Containment Bioinformatics 69

Pharmaceutical Technology

AUGUST 1, 2022

4/5 strain messenger RNA (mRNA). The mRNA-1273.222 vaccine containing the BA.4/5 The contract comprises a $1.74bn award to produce and supply these vaccine doses and options to further procure up to 234 million additional doses of the company’s booster candidates. Another vaccine, mRNA-1273.214, comprises the BA.1

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Scienmag

FEBRUARY 19, 2021

Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells Credit: DGIST Despite our great progress in understanding various cellular mechanisms over the last decades, many of them remain unclear. The […].

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Containment RNA Protein Genetics 52

Scienmag

JANUARY 27, 2022

A Rutgers study has detected tiny airborne particles containing RNA from the SARS-CoV-2 that causes COVID-19, both inside and outside of the rooms in which infected people were self-isolating at home. The study, […].

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Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

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Genome Genomics RNA Protein 70

Roots Analysis

AUGUST 16, 2023

Given such technical and operational challenges associated with the production of RNA-based products, innovators in the biopharmaceutical industry are increasingly relying on the contract manufacturing service providers to cater to the urgent global demand.

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Contract Manufacturing Manufacturing Marketing RNA 52

XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. Moreover, Berrio says the changes likely affected the folding and function of viral RNA. We’ll need to be able to recognize it and make efforts to contain it early.”.

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RNA Protein Genome Genomics 98

Drug Discovery World

OCTOBER 19, 2022

Yapan Bio has expanded its capabilities with a new process development facility at Genome Valley, Hyderabad, India, which has enhanced its ability to support end-to-end development and manufacturing of RNA, DNA and gene therapy products starting from plasmids. .

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Development Gene Therapy RNA DNA 52

Drug Discovery World

JANUARY 11, 2024

Researchers have used messenger RNA (mRNA) to create an effective therapy for a rare liver disease in preclinical studies, demonstrating the technology’s potential therapeutic use in people. mRNA contains instructions that direct the cells to make proteins.

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Research Gene Therapy RNA Gene 59

The Pharma Data

AUGUST 16, 2021

The antiviral agent incorporates RNA-like building blocks into the RNA genome of the virus. If this genetic material is further replicated, defective RNA copies are produced and the pathogen can no longer spread. When it enters the cell, it is converted into RNA-like building blocks.

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RNA Drugs Genome Genomics 52

Drug Discovery World

OCTOBER 25, 2023

CRISPR-Ready ioGlutamatergic Neurons are first-in-class stem-cell derived human neurons containing a constitutively-expressed Cas9 nuclease for gene knockouts and CRISPR screens. The potential applications include studies of neurodegenerative diseases such as Parkinson’s and Huntington’s disease as well as certain types of dementia.

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Genome Genomics Gene Scientist 52

XTalks

JANUARY 3, 2024

Amvuttra: Alnylam’s Similar Treatment on the Market In 2022, Alnylam, a US-based biopharma company with expertise in RNA interference therapeutics for genetically defined diseases, received FDA approval for its drug Amvuttra (vutrisiran) for the treatment of hATTR.

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Roots Analysis

MARCH 8, 2023

INTRODUCTION TO EXOSOMES Exosomes are extracellular vesicles, which have endosomal origin and may contain different biomolecules, including proteins, DNA, lipids, miRNA or RNA , based on the type of cell of their origin and its conditions. Exosomes convey a wide range of information to the target cells, depending on their source.

RNA 52

RNA Drug Delivery DNA Development 52

pharmaphorum

NOVEMBER 16, 2022

The study of GSK3036656 – an inhibitor of the bacterial enzyme leucyl t-RNA synthetase (LeuRS) – showed that 14 days’ treatment with a low once-daily dose showed it was able to kill Mycobacterium tuberculosis in patients with drug-susceptible pulmonary tuberculosis , with no serious adverse effects.

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XTalks

JUNE 14, 2023

The solution of Vevye does not contain water, anti-microbial preservatives, oils or surfactants. Miebo contains perfluorohexyloctane as its active ingredient, a semifluorinated alkane that forms a protective layer over the tear film, reducing evaporation at the ocular surface. Vevye (cyclosporine ophthalmic solution) 0.1

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Gene Silencing Drug Delivery FDA Approval RNA 97

pharmaphorum

SEPTEMBER 14, 2021

The Cambridge, Massachusetts biotech is focusing specifically on the 60% of DNA sequences that repeat themselves hundreds or thousands of times in the genome, known as the ‘repeatome’, that could contain targets for cancer and autoimmune disorders. That muffles the immune system response and allows the cancer to grow.

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DNA Immune Response Genome Genomics 52

pharmaphorum

MAY 26, 2022

His work on a technique known as Hijack RNA, which tricks viruses into killing the cells they infect, underpins Enochian’s antiviral pipeline. The DoJ notes that the indictment charging Gümrükcü and Eratay “contains accusations only, and the defendants are presumed innocent until and unless proven guilty.”

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Gene Expression RNA Licensing Licensing 102

The Pharma Data

OCTOBER 27, 2020

“Applying 3a’s proprietary enhanced RNA technology to PCR testing was a logical next step in our product development pipeline,” said Dr. Heinrich Jehle, managing director of 3a-Diagnostics. “We are currently developing two saliva-based tests to detect SARS-CoV-2 RNA. About XPhyto Therapeutics Corp.

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XTalks

APRIL 29, 2021

Compared to standard plasma HIV-1 RNA drug resistance profiling, which requires a viral load of at least 500 copies per mL, proviral HIV-1 testing can be performed on samples with much lower virion counts of <50 copies per mL (below the detectable limit in RNA testing). Proviral DNA Genotyping.

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DNA Drugs RNA Genotype 98

Drug Discovery World

AUGUST 9, 2023

Read more: Théa acquires ProQR’s RNA ophthalmic assets Sygnature Discovery acquires NuChem Sciences Sygnature Discovery acquired Canada-based contract research organisation NuChem Sciences, expanding its business operations into the North American market.

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Drugs Drug Delivery Systems Drug Delivery Life Science 52

Pharmaceutical Technology

DECEMBER 9, 2022

Our QC testing capabilities range from solids, semi-solids and liquids for oral, inhaled and injectable use to packaging materials, including rubber closures, glass and plastic containers. Ribonucleic acid (RNA) based technologies are among many innovative approaches explored to tackle the Covid-19 pandemic.

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pharmaphorum

MARCH 29, 2022

We designed BIIB078 to test the prevailing hypothesis that the mechanisms of disease for C9orf72-associated ALS were caused by toxicity associated with the repeat containing RNA and corresponding dipeptides,” said C.

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Trials RNA Containment Genetics 48

XTalks

DECEMBER 1, 2021

While most of the current COVID-19 PCR tests involve detection of spike RNA, Cue’s test does not and, instead, is based on identifying RNA encoding the virus’s nucleocapsid proteins. Similarly, Abbott explained that both its rapid antigen and PCR tests do not depend on detection of the genetic material that codes for spike.

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Gene Genome Genomics Genetics 105

pharmaphorum

DECEMBER 7, 2020

On top of this is the requirement for the cutting-edge RNA-based vaccines to be stored at ultra-low temperatures. Most portable vaccine carriers and cold containers cannot keep cold beyond 12 hours, especially if it is hot outside.

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Pharmaceutical Technology

OCTOBER 28, 2022

For companies in the US, if the results show bioequivalence, an abbreviated new drug application (ANDA) containing the results is sent to the FDA to review and potentially approve. In the case of generics, the only concerns you might see is where the brand name and generic drug contain different excipients,” explained Dr Amiji. “A

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Worldwide Clinical Trials

JUNE 15, 2022

Further, some patients are still hesitant to go into the clinic, and the prevalence of misinformation from the pandemic has led to greater concerns about therapies like gene therapies and the impact they fear it will have on their RNA/DNA. IBCs perform a full risk assessment and propose solutions to mitigate the risks.

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Gene Therapy Gene Clinical Trials Clinical Trials 130

The Pharma Data

OCTOBER 25, 2020

Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. 26, 2020 11:00 UTC. CAMBRIDGE, Mass.–( About Moderna. Moderna has been named a top biopharmaceutical employer by Science for the past five years. To learn more, visit www.modernatx.com. Forward-Looking Statements.

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Roots Analysis

AUGUST 15, 2023

Additionally, these types of cell free systems do not contain proteases and nucleases as crude cell lysates, which further helps in improving the production of many proteins. Such systems provide control over the components used for the synthesis of target products making it easier to manipulate the contents according to specific needs.

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Protein In-Vitro Production Reagent 52

XTalks

AUGUST 18, 2020

Moreover, samples for the SalivaDirect test can be collected in any sterile container, and hence does not require any specific type of swab or collection vessel, making collection quick and easy. This is significant because shortages of RNA extraction kits have been a recurrent issue since the beginning of the pandemic.

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FDA Approval Reagent RNA Genome 90

Pharmaceutical Technology

MAY 2, 2023

4/5 Covid-19 messenger RNA (mRNA) vaccines. The use of these current vaccines is important from a public health perspective as they are likely to play a role in further containing the spread of Covid-19 and speeding up the pace of reaching herd immunity.

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pharmaphorum

MAY 24, 2022

While health authorities are on alert, the WHO said it thinks the outbreak can be contained and that the overall risk to the population remains low. Monkeypox is considered less likely to mutate quickly because it is a DNA virus rather than an RNA virus like influenza or COVID-19.

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Vaccination Vaccine RNA DNA 84

Pharmaceutical Technology

SEPTEMBER 8, 2022

A first-in-human drug product, ARDS-003 contains the active pharmaceutical agent, Onternabez. A selective viral RNA-dependent RNA polymerase (RdRP) inhibitor, Favipiravir has antiviral activity against single-stranded RNA viruses, such as coronaviruses. Qifenda is a broad-spectrum antiviral drug in the commercial stage.

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Development RNA Containment Drugs 331

The Pharma Data

MARCH 8, 2021

In both studies, >98% of participants who initiated treatment with Biktarvy and remained in the study achieved and maintained an undetectable viral load (HIV-1 RNA <50 copies/mL) through four years of follow-up (n=235/237 for study 1489, n=241/243 for study 1490). BOXED WARNING: POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B.

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Containment RNA Drugs Protein 52

Advarra

MARCH 31, 2023

This trend came to the forefront during the COVID-19 pandemic, as the three most popular vaccines developed in response to the coronavirus contained engineered genetic materials in the form of mRNA or a genetically engineered virus.

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Engineer Genetics Clinical Research Research 52

The Pharma Data

DECEMBER 17, 2020

Words such as “expects,” “intends,” “indicator” “progress towards” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements necessarily contain these identifying words. Our mission is to empower precision medicine at the local level.

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The Pharma Data

OCTOBER 28, 2020

Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today confirmed that the Ministry of Health, Labour and Welfare of Japan (MHLW) and Takeda Pharmaceutical Co., 29, 2020 06:00 UTC. CAMBRIDGE, Mass.–(

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The Pharma Data

AUGUST 30, 2021

As the first and only small interfering RNA to provide effective and sustained LDL-C reduction, Leqvio helps manage a critical cardiovascular risk factor for ASCVD. Leqvio is the first and only approved small interfering RNA (siRNA) LDL-C-lowering treatment in Europe 6,7. It is currently under review by the U.S. Disclaimer.

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