Synplogen and Ginkgo Bioworks sign MoU for DNA manufacture
Pharmaceutical Technology
DECEMBER 7, 2023
Synplogen and Ginkgo Bioworks have signed an MOU to expedite DNA manufacturing and gene therapy platform services in Japan.
A new startup from Feng Zhang and an ex-Illumina executive zeroes in on the epigenome
Bio Pharma Dive
JANUARY 4, 2024
Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.
Gene Editing 
349
349 Join 32,000+
Insiders
Sign Up for our Newsletter
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Sartorius upscales gene therapy prowess with $2.6bn Polyplus acquisition
Pharmaceutical Technology
APRIL 3, 2023
The deal will see Polyplus join the German life science group’s portfolio allowing the latter to leverage expertise in transfection reagents and plasmid DNA for gene therapy. Polyplus, based in Strasbourg, France, produces key components in the production of viral vectors used in cell and gene therapies.
Gene Therapy 246
246 
World’s largest catalogue of ocean DNA could boost drug discovery
Drug Discovery World
JANUARY 23, 2024
Scientists at the King Abdullah University of Science and Technology (KAUST) in Thuwal, Saudi Arabia used the KAUST Metagenomic Analysis Platform (KMAP) to analyse massive amounts of sequencing data to release Global Ocean Gene Catalog 1.0.
DNA 103
103 
Gene Therapy and Pharmacokinetics
Camargo
JULY 27, 2021
How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Therapy Definition.
Gene Therapy 238
238 
Unlocking the potential of synthetic DNAÂ
Drug Discovery World
NOVEMBER 20, 2023
Raquel Sanches-Kuiper , Vice President of Science and Applications at Evonetix, and Clare Whitewoods , Marketing Communications Manager at Evonetix, look at the benefits synthetic DNA brings to pharmaceutical development.
DNA 69
69 
Blocking DNA production in cancer therapy by targeting the POLtheta enzyme
Medical Xpress
NOVEMBER 17, 2022
BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instances, leading to breast and ovarian cancer, plays an important role in the body's DNA repair mechanisms. BRCA1, once mutated, can cause cancer to develop.
DNA 119
119 
New facility boosts UK’s cell and gene therapy manufacturing capacity
Pharmaceutical Technology
MARCH 10, 2023
On 10 March, the National Health Service Blood and Transplant (NHSBT) opened a new Clinical Biotechnology Centre (CBC) with the aim of improving the UK’s ability to develop and manufacture cell and gene therapies. The strategy , underlines one of the government’s goals of increasing the UK’s manufacturing capacity for DNA-based therapeutics.
Gene Therapy 264
264 
Researchers discover key role of DNA methylation in Alzheimer's disease
Medical Xpress
FEBRUARY 22, 2023
Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).
DNA 98
98 
UK scientists say they have found cancer driver in junk DNA
pharmaphorum
JULY 20, 2022
It has suspected for many years that some diseases may be linked to non-coding or ‘junk’ DNA, but the mechanism behind the pathology hasn’t been worked out. Junk DNA is a term used to describe the 97% of the genetic sequence in human cells found between the 3% coding for our 20,000 genes, once thought to be inert.
DNA 114
114 
New London facility exceeds global plasmid DNA demandÂ
Drug Discovery World
MAY 24, 2023
Touchlight, a company providing DNA services and manufacturing enzymes, has completed the redevelopment and expansion of its UK manufacturing facility in London, UK. The expanded facility’s manufacturing capacity has tripled and is now capable of producing more than 8kg a year.
DNA 52
52 
Gene editing DNA deletion sizes reduced with new fusion method developed at WFIRM
Scienmag
MAY 2, 2022
WINSTON-SALEM, NC – May 2, 2022 — Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.
Gene Editing 58
58 
Scientists use DNA origami to monitor CRISPR gene targeting
Scienmag
FEBRUARY 23, 2021
CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes; to watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to me Credit: Image courtesy of Julene Madariaga Marcos.
DNA 56
56 
Desktop DNA synthesis could ‘revolutionise’ engineering biology
Drug Discovery World
MAY 11, 2023
The first DNA synthesised using Evonetix’s semiconductor chip technology has been delivered to the Department of Chemical Engineering and Biotechnology at the University of Cambridge. The DNA was delivered to Dr Jenny Molloy, Co-chair of the Engineering Biology Interdisciplinary Research Centre at the University of Cambridge.
DNA 52
52 
Moderna partners with Life Edit for mRNA gene editing therapies
Pharmaceutical Technology
FEBRUARY 23, 2023
Moderna has entered a strategic research and development partnership with ElevateBio’s Life Edit Therapeutics to discover and develop new in-vivo mRNA gene editing therapies. The company’s nuclease collection includes several Protospacer Adjacent Motifs (PAMs), short sequences that help determine the genome’s DNA segments.
Gene Editing 147
147 
STAT+: After early wins, CRISPR gene editing is about to get a lot harder
STAT News
SEPTEMBER 21, 2022
The short history of CRISPR gene editing in humans has, with rare exception, been a history of triumphant progress: A patient apparently cured of sickle cell in 2019, six patients with toxic DNA knocked out of their liver last year, another six patients with a different strand of toxic liver DNA knocked out last week.
Gene Editing 128
128 
Opinion: Needed: stricter screening of gene synthesis orders, customers
STAT News
OCTOBER 5, 2022
Scientists rely on gene synthesis technologies as a research tool for everything from basic research to vaccine development and drug target identification. Ever since the inception of gene synthesis, there have been concerns about possible misuse of synthetic genes.
Gene 98
98 
Researchers speed identification of DNA regions that regulate gene expression
Scienmag
MAY 6, 2021
Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Credit: St. Jude Children’s Research Hospital St.
Mitochondrial drugs, with a twist: Pretzel Therapeutics launches with $72.5M in funding
Bio Pharma Dive
SEPTEMBER 12, 2022
Scientists at Pretzel believe fixing mutated mitochondrial DNA with a mix of small molecule therapies and gene editing could be key to solving a number of hard-to-treat diseases.
Gene Editing 256
256 
A startup emerges with $125M and plans to edit the epigenome
Bio Pharma Dive
NOVEMBER 17, 2021
Chroma Medicine's launch is the latest step in a decadeslong quest by drugmakers to capitalize on research into epigenetics, a way of controlling gene expression without altering DNA.
Gene Expression 311
311 
STAT+: Intellia says CRISPR treatment safely corrects DNA of six patients with rare disease
STAT News
SEPTEMBER 16, 2022
Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells.
DNA 142
142 
Forge adds plasmid DNA manufacturing to integrate gene therapy production service
BioPharma Reporter
OCTOBER 20, 2022
Forge Biologics has added plasmid DNA manufacturing to its roster of services, enabling it to vertically integrate its production process.
DNA 75
75 
Novel artificial genomic DNA can replicate and evolve outside the cell
Scienmag
NOVEMBER 20, 2021
Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.
DNA 96
96 
DNA therapy effective against chemo-resistant ovarian cancer
Drug Discovery World
DECEMBER 4, 2023
A novel DNA vaccine in combination with chemotherapy has demonstrated promising clinical results against a deadly form of ovarian cancer. The investigational compound Elenagen is an experimental DNA therapy that consists of a circular piece of DNA called a plasmid that includes a gene for a human protein called p62/SQSTM1.
DNA 59
59 
Princeton-led study of DNA repair boosts prospects for gene editing technology
Scienmag
OCTOBER 20, 2021
The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all.
DNA 75
75 
GenScript ProBio and CCS partner for cell and gene therapies development
Pharmaceutical Technology
JUNE 8, 2023
GenScript ProBio has collaborated with the New York Blood Center Enterprises’ business unit, called Comprehensive Cell Solutions (CCS), to accelerate the development and manufacture of cell and gene therapies. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
Gene Therapy 130
130 
Ionis teams with Metagenomi and dives into gene editing
Bio Pharma Dive
NOVEMBER 14, 2022
The RNA drug developer is paying the richly-funded startup $80 million in a wide-ranging alliance that marks its first foray into DNA editing medicines.
Gene Editing 156
156 
Faulty DNA repair may lead to BRCA-linked cancers
Medical Xpress
NOVEMBER 15, 2022
Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators. The discovery has potential implications for preventing the development of cancer in patients with these mutations.
DNA 75
75 
Gene p16, which drives colorectal cancer, is emerging as a target for potential therapies
Medical Xpress
MAY 10, 2023
How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models.
Gene 105
105 
Epigenic joins wave of startups raising cash to edit the epigenome
Bio Pharma Dive
AUGUST 30, 2023
The China-based company is one of at least four young biotechs in a competitive race to use CRISPR tools to alter gene expression without changing DNA.
Gene Expression 148
148 
Intellia cleared to start key CRISPR drug study in UK
Bio Pharma Dive
OCTOBER 19, 2020
The trial would be the first test of a systemically administered gene editing treatment that uses the Nobel Prize-winning technology to alter DNA.
Gene Editing 315
315 
#news #biotech Fluorescence lifetime imaging for studying DNA compaction and gene activities
BioTech 365
DECEMBER 27, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Fluorescence lifetime imaging for studying DNA compaction and gene activities.Studies of the genomic DNA compaction in the cell nucleus and dynamic reorganization during physiologic processes or disease … Continue reading (..)
DNA 40
40 
New gene implicated in cancer, cellular stress response
Medical Xpress
FEBRUARY 21, 2023
Northwestern Medicine scientists have identified a gene that plays a role in cellular responses to molecular stressors, such as DNA damage and nutrient scarcity, according to findings published in Nature Communications.
Gene 75
75 
Study identifies two genes linked to microcephaly
Medical Xpress
DECEMBER 15, 2022
Northwestern Medicine scientists have identified disease-causing DNA variants in two genes linked to neurodevelopmental deficits including microcephaly in children, according to findings published in Nature Communications.
Gene 75
75 
Huge U.S. study starts sharing gene findings with volunteers
STAT News
DECEMBER 13, 2022
More than 155,000 Americans who shared their DNA for science are about to learn something in return: Do they have some particularly worrisome genes? It’s part of a massive project to unravel how people’s genetics, environments, and habits interact to determine their overall health.
Gene 105
105 
DNA Cloning Market: A Step Towards Future of Genetics Science
Roots Analysis
JUNE 1, 2022
DNA cloning is the field of synthetic biology which can be helpful to understand the effect of mutation on a particular gene. Many diseases that can be treated using DNA cloning, such as leukemia and sickle cell anemia, involving the replacement of defected gene. DNA Cloning Kit Providers – Current Market Landscape.
DNA 52
52 
Leading innovators in IgG gene expressing animal models for the pharmaceutical industry
Pharmaceutical Technology
FEBRUARY 15, 2023
In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: IgG gene expressing animal models. To obtain human antibody responses within a mouse, mice are genetically engineered to be humanised for their Ig genes.
Gene Expression 130
130 
New mouse study shows genes aren’t only way to pass obesity to next generation
STAT News
FEBRUARY 7, 2023
But a new study in mice provides the clearest evidence yet that acquired traits can be passed down from one generation to the next in mammals without DNA changes, challenging centuries of evolutionary dogma and raising fresh questions about the factors that affect our health. Read the rest…
Gene 105
105 
STAT+: New CRISPR startup, drawing big-name backers, seeks to fix diseases caused by large DNA errors
STAT News
SEPTEMBER 20, 2022
A new CRISPR startup — backed by some big names in venture capital — is planning to develop gene-editing treatments that can insert a genetic sequence of any length, at any location in the DNA strand, according to industry insiders and documents.
DNA 98
98 
New method boosts the study of regulation of gene activity
Scienmag
JULY 1, 2022
One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].
Regulation 63
63 
Researchers teach AI to tailor artificial DNA for drug development
Drug Discovery World
NOVEMBER 29, 2022
Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . First it was about being able to fully ‘read’ the DNA molecule’s instructions. The next step is to use human cells.
DNA 52
52 
STAT+: After blazing trails in RNA-targeted drugs, Ionis jumps into gene editing
STAT News
NOVEMBER 14, 2022
Ionis Pharmaceuticals, the California company that turned RNA-targeting medicines from an unproven idea into blockbuster drugs, is now expanding into a new class of therapeutics that treat disease by editing DNA. On Monday, the company announced a partnership with Metagenomi to kickstart these efforts.
Gene Editing 98
98 
Gene editing: beyond the hype
pharmaphorum
JANUARY 29, 2021
Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. Zinc fingers.
Gene Editing 144
144 
Is single-cell gene expression the next trend in next generation sequencing?Â
Drug Discovery World
OCTOBER 10, 2022
By Dr Dina Finan, PhD, Product Manager at 10x Genomics and Dr Nick Downey, PhD, NGS Collaborations Lead at Integrated DNA Technologies. The post Is single-cell gene expression the next trend in next generation sequencing? While bulk sequencing—or sequencing the transcriptome of an entire sample at once—has contributed to many [.].
Let's personalize your content