XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. When people think about innovation drivers in global healthcare, they often think of “big pharma,” and not necessarily companies in the plasma medicines space.

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Medicine Recombinant Antibody Protein Antibody 111

Pharmaceutical Technology

APRIL 10, 2023

Health director-general Tan Sri Dr Noor Hisham Abdullah stated that the approval of Evusheld was granted at the 383rd Drug Control Authority (DCA) meeting. The approval comes after the therapy was granted conditional registration approval during the 372nd DCA meeting.

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Immune Response Antibody Vaccination Vaccine 264

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

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Immune Response Development Medicine Drugs 52

pharmaphorum

OCTOBER 12, 2022

Having spent 10 years working in the genomics field, Del Bourgo noticed manufacturers spending extensive resources on drug development without harnessing the transformative power of data. Genomic medicine is a rapidly growing space in which researchers use the information in a person’s genes to identify and administer medical treatment.”.

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Genome Genomics Medicine Development 92

Drug Discovery World

APRIL 12, 2024

The cancer research news has been coming thick and fast from the American Association of Cancer Research (AACR) Annual Meeting in San Diego this week, so our Friday round-up focuses on drug discovery in oncology. The post This week in drug discovery (8-12 April) appeared first on Drug Discovery World (DDW).

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Drugs Genetic Engineering Immune Response Engineer 52

Pharmaceutical Technology

NOVEMBER 11, 2022

The latest development comes after the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) provided a positive opinion on vaccine use. The vaccine elicited a robust immune response against several variants in registrational trials conducted when the Omicron variant of the virus was dominant.

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Cloudbyz

MARCH 5, 2024

In the intricate dance of drug discovery and development, two protagonists emerge as the cornerstones of modern medicine: biologics and small molecules. Manufacturing Process : Small Molecules: Manufactured through chemical synthesis, small molecule drugs can be consistently reproduced with a high degree of purity and stability.

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Development Drugs Manufacturing Immune Response 78

STAT News

DECEMBER 13, 2022

Medicines that reshape or tamp down immune responses may be life-changing for patients with cancer and autoimmune disorders, but in some cases they can awaken a dormant virus and unleash a deadly brain disease. A new study suggests that the root of the problem is buried in our genetic code.

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Genetics Immune Response Gene Drugs 105

Pharmaceutical Technology

FEBRUARY 6, 2023

Led by Feinstein Institutes researcher Haichao Wang, the new study focuses on detecting protein mediators that might contribute to uncontrolled immune responses to lethal infections. Feinstein Institutes Institute of Molecular Medicine professor Dr Wang said: “Sepsis is a complex and fatal complication.

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Protein Research Antibody Immune Response 263

NY Times

MAY 11, 2022

Antibody levels rose in the children who received it, suggesting the vaccine protects against infection. But the data were gathered before the arrival of Omicron.

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Immune Response Vaccination Vaccine Antibody 62

Scienmag

MAY 28, 2021

The drug diABZI — which activates the body’s innate immune response — was highly effective in preventing severe COVID-19 in mice that were infected with SARS-CoV-2, according to scientists in the Perelman School of Medicine at the University of Pennsylvania.

Immune Response 71

Immune Response Drugs Scientist Research 71

Pharmaceutical Technology

DECEMBER 16, 2022

The example of rituximab, originally a cancer drug, now used for lupus, has shown the potential of adopting cancer medications for lupus. In a recent paper in Nature Medicine by Mackensen and colleagues, a CD19 CAR-T cell therapy was successfully used to treat five patients with refractory SLE.

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Drug Discovery World

SEPTEMBER 7, 2023

A new study, led by scientists at Oregon Health & Science University (OHSU), has revealed that a form of cell death known as ferroptosis – caused by a build-up of iron in cells – destroys microglia cells, a type of cell involved in the brain’s immune response, in cases of Alzheimer’s and vascular dementia.

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Scientist Drugs Immune Response Medicine 64

Drug Discovery World

APRIL 9, 2024

A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendritic cells directly into cancerous lung tumours can help promote a stronger immune response. Additionally, they observed that this therapy helped to establish a long-lasting immune response against the cancer.

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Genetic Engineering Engineer Genetics Immune Response 52

Drug Discovery World

OCTOBER 6, 2022

Precision medicine promises a paradigm shift to confidently match the right patients to the right treatment at the right time. In the cancer space alone over the last five years, clinical trials have increased 500% for new drugs and new drug combinations.

Medicine 52

Medicine Clinical Trials Clinical Trials Genome 52

Scienmag

APRIL 12, 2021

BOSTON – Exercise training may slow tumor growth and improve outcomes for females with breast cancer – especially those treated with immunotherapy drugs – by stimulating naturally occurring immune mechanisms, researchers at Massachusetts General Hospital (MGH) and Harvard […].

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Immune Response Drugs Research Allergies 41

Drug Discovery World

AUGUST 3, 2023

Bimervax from HIPRA Human Health has been authorised in the UK after meeting the Medicines & Healthcare products Regulatory Agency’s (MHRA) required safety, quality and effectiveness standards. It becomes the ninth Covid-19 vaccine to be authorised by the UK’s independent medicines regulator.

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pharmaphorum

MAY 11, 2021

Flagship Pioneering, the VC fund run by Moderna’s co-founder Noubar Afeyan has launched a new biotech Laronde , with an ambitious plan to create a new class of drugs based on Endless RNA. Called eRNA for short, this class of medicines is programmable and can continuously express therapeutic proteins inside the body.

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RNA Drugs Protein Immune Response 98

Drug Discovery World

JULY 31, 2023

Because of the Covid-19 vaccine success, many drug programmes pivoted to mRNA- based strategies for other diseases, including influenza, shingles, multiple sclerosis, or heart conditions, with several therapies having regulatory approval or in clinical.

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DNA Medicine Manufacturing Production 52

Pharmaceutical Technology

APRIL 24, 2023

Researchers may develop nanodrugs due to their smaller surface area to allows drugs to dissolve faster, or nanoparticles may encapsulate drugs, so they last longer in the body. This intersection will be remembered as one of the most significant achievements in science and medicine”.

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Drug Discovery World

FEBRUARY 13, 2023

Dr Stephen Barat, Senior Vice President and Therapeutics Division Head at HTG Molecular Diagnostics tells DDW how transcriptomics is driving drug discovery and precision medicines. DDW: What are some of the challenges in early-stage drug discovery and development? DDW: Could you explain the process of transcriptomics?

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RNA Drugs Gene Expression Gene 52

Pharmaceutical Technology

APRIL 28, 2023

THN391 binds the inflammation-driving component of fibrin, known for activating the immune responses in neurodegenerative and ophthalmologic diseases. Therini Bio will use part of the funds to advance its potential first-in-class investigational antibody, THN391, into clinical trials.

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Drug Discovery World

AUGUST 7, 2023

Evox Therapeutics has agreed a research collaboration and option agreement with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) in New York, NY, US. Susmita Sahoo, Associate Professor of Medicine, Cardiology at Icahn Mount Sinai has been exploring the use of exosomes in gene therapy for several years.

Gene Therapy 52

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Scienmag

JANUARY 26, 2022

WHAT: In adults who had previously received a full regimen of any of three COVID-19 vaccines granted Emergency Use Authorization (EUA) or approved by the Food and Drug Administration (FDA), an additional booster dose of any of these vaccines was safe and prompted an immune response, according to preliminary clinical trial results reported in The […]. (..)

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Vaccination Vaccine Immune Response Trials 84

Drug Discovery World

APRIL 11, 2024

We have noted that cancer patients can develop powerful anti-tumour immune responses that can result in complete cure of the disease and we call these patients ‘elite responders’. By understanding what triggers the adaptive immune response in “elite responders” we have identified new targets and therapeutic antibodies.

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Research Immune Response Antibody Medicine 59

Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

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Bacteria Drugs Gene Immune Response 52

Drug Discovery World

APRIL 3, 2023

A team of researchers at the Keck School of Medicine of University of Southern California (USC) have found a drug with the potential for curbing painful hyperinflammation from osteoarthritis, according to results of an animal study. In trying to fix the problem, the immune system causes even more damage,” said Evseenko.

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Clinical Trials Clinical Trials Trials Drugs 52

Drug Discovery World

AUGUST 31, 2023

Could boost immune response to cancer The scientists demonstrated that thymic stem cells contribute to the environment by producing proteins of the extracellular matrix, which functions as their own support system.

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Drug Discovery World

FEBRUARY 5, 2024

DDW’s Megan Thomas spoke to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. Through early diagnosis and precision medicine, we can improve quality of life and enable more people with cancer to survive. This is part of a series of predictions based on different themes.

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pharmaphorum

JULY 5, 2021

The reason none of them can say with certainty whether or not they are truly safe is because everyone’s immune response is unique to that individual. In some cases, we see significant variations among similarly aged people with similar health histories when it comes to their individual responses to the virus or vaccines.

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Drug Discovery World

NOVEMBER 30, 2022

Bio-chromatography company Sartorius BIA Separations (BIA) and exosomes medicines company Exopharm have signed a Material Transfer Agreement and associated collaborative programme. . The post Partnership hopes to improve large-scale exosome production appeared first on Drug Discovery World (DDW).

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Production Immune Response RNA Gene 52

Roots Analysis

FEBRUARY 28, 2024

On 28 October 2019, CARsgen Therapeutics , a clinical-stage biopharma company, announced that the FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to its investigational CT053 CAR-T cell therapy.

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Immune Response Development Medicine Drugs 52

The Pharma Data

APRIL 15, 2022

Food and Drug Administration in the coming days with additional submissions to other regulatory agencies worldwide to follow. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Pfizer Inc.

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Drug Discovery World

MARCH 26, 2024

The US Food and Drug Administration (FDA) has granted emergency use authorisation (EUA) to half-life extended monoclonal antibody (mAb) Pemgarda (pemivibart, or VYD222) for the pre-exposure prophylaxis (prevention) of Covid-19.

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Drug Discovery World

AUGUST 16, 2022

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved an updated version of Moderna’s Covid-19 booster vaccine that targets two coronavirus variants. . Known as a bivalent vaccine, Spikevax was approved following data that show it triggers a strong immune response against both Omicron (BA.1) References .

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Immune Response Vaccination Vaccine Clinical Trials 52

pharmaphorum

SEPTEMBER 29, 2022

Sanofi and Regeneron have claimed the first approval in the US for a drug for prurigo nodularis, after the FDA gave a green light to Dupixent as a treatment for adults with the rare skin disease following a priority review. The post FDA clears Dupixent as first drug for rare skin disorder appeared first on.

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Drugs Immune Response Allergies Sales 67

pharmaphorum

NOVEMBER 14, 2022

Sanofi and Regeneron’s Dupixent is on track to become the first targeted drug in the EU to be approved for prurigo nodularis (PN), a rare and highly debilitating skin disease. Sanofi and Regeneron are running a phase 3 trial of the drug in COPD patients with type 2 inflammation called NOTUS that is due to generate results next year.

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Sales Immune Response Drugs Medicine 99