Tue.Mar 15, 2022

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Passage Bio to cut jobs in latest biotech restructuring

Bio Pharma Dive

Stung by a stock market downturn, a number of biotechs are trimming spending and reprioritizing research to save cash. Passage's layoffs will reduce its workforce by 13%.

Marketing 310
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NHS mental health referrals has reached record high

Pharma Times

COVID-19 has highlighted another significant widespread problem – the mental health pandemic

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Sanofi lures Blackstone backing in unusual deal for multiple myeloma drug

Bio Pharma Dive

Rather than fund development of a more convenient version of its blood cancer drug Sarclisa on its own, Sanofi has instead turned to Blackstone, which has fast become one of the sector's more active investors.

Drugs 277
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Sanofi announces €300m collaboration with Blackstone Life Sciences for multiple myeloma treatment

BioPharma Reporter

Sanofi and Blackstone today announced a strategic, risk-sharing collaboration under which funds managed by Blackstone Life Sciences will contribute up to â300m ($329m) to accelerate development for subcutaneous formulation and delivery of anti-CD38 antibody Sarclisa to treat patients with multiple myeloma (MM).

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Unlocking Excellence: How Catalent Is Transforming Japan’s Clinical Research

Planning on running clinical trials in Japan? How can you reliably supply these studies? Discover Catalent’s clinical supply packaging facility in Shiga, Japan. Strategically located between Tokyo and Osaka, and one of largest in Japan, this 6,000 square meter facility offers comprehensive services including primary and secondary clinical packaging and labelling, comparator sourcing, cold chain storage, local and global distribution, local language support and white glove service to support stud

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Merck bid to combine two top drugs for prostate cancer falls short

Bio Pharma Dive

The pharma ended a large study of Keytruda and Lynparza early after disappointing results, a setback for a combination that research has suggested could treat a range of cancers.

Drugs 148
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Eisai hands off responsibility for Aduhelm to Biogen

pharmaphorum

Japanese pharma Eisai has backed away from its 50:50 profit-sharing arrangement with Biogen for troubled Alzheimer’s therapy Aduhelm, handing over full responsibility to its US counterpart. The changes to the terms of their longstanding collaboration on Aduhelm (aducanumab) means that Eisai’s profit-share converts to a simple royalty rate on revenues from 1 January next year.

Sales 118

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Pharma group seeks digital measure standards for Alzheimer’s

pharmaphorum

A group of pharma companies and academic groups have joined forces with the Digital Medicine Society (DiMe) to develop standardised, digital clinical measures that can be used in the development of therapies for Alzheimer’s disease and related dementias. According to the consortium – which includes drugmakers Biogen, Eisai, Eli Lilly and Merck & Co – there is a lack of measures that can be used to determine whether new therapies for Alzheimer’s are actually working.

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These Food Companies are Cutting Ties with Russia Amid War with Ukraine

XTalks

Hundreds of companies have announced plans to suspend or halt operations in Russia amid the ongoing war with Ukraine, many of which are well-known Western food companies. Among them include food giants like General Mills, Nestlé and Cargill. But a small number of companies are still doing business in Russia, including Restaurant Brands International (RBI), the owner of Burger King.

Sales 98
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Disrupted medical conferences: Lessons learnt

pharmaphorum

The new normal is already here. Get used to it. The COVID-19 pandemic has radically disrupted traditional medical society conferences in a way that could scarcely have been imagined in 2019. The vast majority of societies were able to transition their planned physical events to virtual formats within remarkably short periods of time, and some delivered impressive attendee experiences.

Doctors 105
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Birds of prey populations across Europe suppressed by lead poisoning from gun ammunition – study

Scienmag

Poisoning caused by preying on or scavenging animals shot by hunters using lead ammunition has left the populations of many raptors – or birds of prey – far smaller than they should be, according to the first study to calculate these impacts across Europe. Credit: Ian McCarthy/RSPB Poisoning caused by preying on or scavenging […].

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The New Age of Decentralized Clinical Trials

White paper that delves into the complex topic of Decentralized Clinical Trials and how to master them within the confines of FDA Regulations

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5 best practices for improving patient engagement

pharmaphorum

Life science companies invest a significant number of resources to engage physicians and patient advocates. However, companies often fall short when it comes to engaging patients in a meaningful way during the product development process. In a new whitepaper, Best Practice Guide: Insights Management and Virtual Patient Engagement, Within3 provides a detailed roadmap to help life science companies navigate engagement in the virtual world.

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Furthering fat loss in the fasting response

Scienmag

Osaka, Japan – The coming of spring harkens spring cleaning; a time to de-clutter your home and discard things that are no longer needed. In the body, a cellular process calledautophagy occurs regularly to “de-clutter” our cells. Recently, researchers in Japan have shed new light on the relationship between this process and the body’s metabolic […].

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Blackstone funds new trials of Sanofi’s Sarclisa in myeloma

pharmaphorum

Sanofi has agreed a deal with life sciences investor Blackstone to help fund clinical trials of a new formulation of Sarclisa for blood cancer multiple myeloma, accelerating its development. Blackstone will provide €300 million in funding for the project, which will focus on a subcutaneous formulation of Sarclisa (carfilzomib) that is due to start a pivotal study later this year.

Trials 97
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High blood pressure genes improve heart surgery survival in children

Scienmag

Children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery, according to a new study published in Circulation Research. Credit: Vanderbilt University Medical Center Children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart […].

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Roles and Responsibilities of Specialized Clinical Supply Experts

When selecting a clinical supply provider, consideration often focuses upon the manufacturing, packaging, storage and distribution capabilities available that will, at face-value, be sufficient to meet the needs of the sponsor and their trial. However, there are human-based and knowledge-driven factors that are often overlooked that go beyond these basic physical capabilities and are integral to the development and delivery of high performing clinical supply chains.

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Real-time Abbott glucose monitor available to NHS after UK launch

pharmaphorum

The latest version of Abbott’s FreeStyle Libre continuous glucose monitor is now available via the NHS to eligible people with diabetes in the UK. Abbott’s wearable FreeStyle Libre 3 device – which is billed as the smallest and thinnest real-time CGM system available – sends glucose readings every minute directly to the user’s smartphone for up to 14 days, allowing them to adjust treatment as needed.

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Tricking the body to treat breast cancer

Scienmag

With the help of two new grants from the National Institutes of Health totaling more than $4.4 million, Sanford Burnham Prebys professor Charles Spruck, Ph.D., and his team are refining a cutting-edge breast cancer treatment. The new approach, known as viral mimicry, tricks the body into thinking that it has a viral infection, stimulating immune responses […].

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NOW AVAILABLE: The 2022 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers

Drug Channels

I am pleased to announce our new 2022 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers , available for purchase and immediate download. Click here to download a free report overview (including key industry trends, the Table of Contents, and a List of Exhibits) New Drug Channels Institute Study Examines Consolidation and Vertical Integration of U.S.

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Staying alive, Arabian oryx style

Scienmag

In a world-first, the DNA of a vulnerable species, the iconic Arabian Oryx, has been decoded. An international team led by the University of Sydney undertook this project to ensure the survival of the species, by using the genetic data to inform breeding programs. Credit: Gongora et al. In a world-first, the DNA of a […].

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The New Age of Decentralized Clinical Trials

This new white paper defines and details the impact of Decentralized Clinical Trials on the Pharmaceutical industry and how the impact can be measured along with steps companies can take to ensure adoption.

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Bill & Melinda Gates Foundation launch initiative for future pandemics

Pharma Times

The initiative will catalyse discovery and early development of antiviral medicines for future pandemics

Medicine 101
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Marine snail inspires fast-acting injectable insulin for better diabetes control

Scienmag

For millions of people with diabetes, insulin is essential medicine. But for some ocean-dwelling predators, insulin is a weapon. With a burst of venom, a fish-hunting cone snail can drop the blood sugar of its prey so precipitously that it quickly becomes paralyzed and defenseless. That remarkable phenomenon has inspired scientists at University of Utah […].

Insulin 82
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Tevogen Bio receives new investment for precision T cell platform

BioPharma Reporter

Clinical stage biotech Tevogen Bio has announced a new strategic investment by HMP Partners, a life sciences investment firm.

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New toolkit aids discovery of mineral deposits crucial to ‘green economy’ transition

Scienmag

Scientists have developed a new toolkit for the discovery of mineral deposits crucial to our transition to a ‘green economy’. A study led by Lawrence Carter from the University of Exeter’s Camborne School of Mines, has given fascinating new insights into how to discover porphyry-type copper deposits. Porphyry-type deposits provide most of the world’s copper […].

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Accelerating Clinical Supply Through Integrated Drug Development

As the development pipeline for new drugs continues to grow, biopharmaceutical companies are re-evaluating how to best manage and balance resources across an increasing number of development projects and complex clinical trials. There are two approaches that can be used to speed a drug from development to clinic faster: timeline compression and parallel processing, but only one that considers the benefits of integrating clinical supply into the overall drug development process.

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Preparing industry leaders for digital transformation

pharmaphorum

In a fireside chat hosted by pharmaphorum’s Jonah Comstock, Healthware Group CEO Roberto Ascione (author of the recent book “The Future of Health”) and Politecnico di Milano Professor Emanuele Lettieri will discuss recent trends in digital transformation in healthcare and life sciences that prompted the creation of the Programme as well as share a little about the programme itself.

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Stand up to Cancer announces $1 million donation from Zentalis Pharmaceuticals to fund targeted cancer therapy research

Scienmag

LOS ANGELES – March 15, 2022 – Stand Up To Cancer® (SU2C) and Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL) today announced that Zentalis will contribute $1 million to the SU2C Catalyst® program to support research that investigates the use of certain small molecule inhibitors for treating a variety of cancer types. Through the SU2C Catalyst® program, […].

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2022 Symposium on Infectious Diseases

Sciensano

Diagnostic and surveillance of infectious diseases Event type: symposium Audience: health professionals scientists specialist in clinical biology Description: Sciensano organises each year a scientific seminar about infectious diseases. The focus of this event is on surveillance, prevention, treatment and epidemics’ management. Have a look at the abstractbook_-_symposium_infectious_diseases_2022.pdf.

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A new brain-computer interface with a flexible backing

Scienmag

Engineering researchers have invented an advanced brain-computer interface with a flexible and moldable backing and penetrating microneedles. Adding a flexible backing to this kind of brain-computer interface allows the device to more evenly conform to the brain’s complex curved surface and to more uniformly distribute the microneedles that pierce the cortex.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Advantages of Conducting Clinical Trials in Australia

ProRelix Research

Clinical trials are research studies in which participants volunteer to test new treatments, therapies, or tests in the hopes of preventing, detecting, treating, or managing a wide range of diseases […]. The post Advantages of Conducting Clinical Trials in Australia appeared first on ProRelix Research.

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Hoverfly brains mapped to detect the sound of distant drones

Scienmag

For the first time, Australian researchers have reverse engineered the visual systems of hoverflies to detect drones’ acoustic signatures from almost four kilometres away. Credit: University of South Australia For the first time, Australian researchers have reverse engineered the visual systems of hoverflies to detect drones’ acoustic signatures from almost four kilometres away.

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Teva Announces Donations of Essential Medicines in Support of Ukrainian Refugees

The Pharma Data

Teva is donating medicines valued at over $11M, for acute therapies in support of Ukrainian refugees The donations include over 1 million packages of antibiotics and other essential medicines as well as hygienic products for Ukrainian infants and children. Teva Pharmaceutical Industries Ltd. today announced a donation of essential medical products valued at over $11M, for acute therapies in humanitarian support of Ukrainian refugees.

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New sabre-tooth predator precedes cats by millions of years

Scienmag

The fossil, housed in The Nat’s paleontology collection, offers a window into what the Earth was like during the Eocene Period, more than 40 million years ago. The specimen includes a lower jaw and well-preserved teeth, giving us new information about the behavior and evolution of some of the first mammals to have an exclusively […].

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The New Clinical Trial Supply Chain: Resilient, Flexible, and Patient-Centric

The global landscape of clinical trials is rapidly changing as studies become more complex. An increasing number of sponsors are seeking enhanced flexibility in their supply chains to address a variety of clinical supply challenges, including patient demand and reducing delays. Demand-led supply and direct-to-patient distribution are next-generation solutions that are helping to meet these growing needs, allowing for more streamlined processes and patient-centric studies.