Scienmag

JANUARY 12, 2021

Martins Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics. The John Innes Centre researchers used the technology to create a new strain of Streptomyces formicae bacteria which over-produces the medically promising molecules.

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Gene Editing Gene Bacteria Scientist 53

Pharmaceutical Technology

NOVEMBER 16, 2022

ElevateBio has entered a partnership with Affini-T Therapeutics to progress the latter’s engineered TCR-T therapies focused on Kirsten rat sarcoma viral oncogene homolog (KRAS), a dominant oncogenic driver mutation in solid tumours.

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Development Gene Therapy Engineer Gene Editing 246

Drug Discovery World

NOVEMBER 1, 2023

DDW’s Diana Spencer meets Dr Stephen Jones, Research Professor and Group Leader at the EMBL Partnership Institute for Genome Editing Technologies at Vilnius University’s Life Sciences Center. SJ: I lead a research group at the EMBL Partnership Institute in Vilnius, Lithuania. SJ: CRISPR is the obvious one.

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Gene Editing Research Gene Genome 59

Pharmaceutical Technology

MAY 25, 2023

ElevateBio has raised $401m in a Series D financing round for advancing its technology platforms to expedite the design, production and development of cell and gene therapies. The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform.

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Gene Therapy Gene Gene Editing Manufacturing 243

Scienmag

JANUARY 5, 2022

SAN FRANCISCO, CA—January 5, 2021—Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Credit: Photo: Michael Short/Gladstone Institutes […].

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Gene Gene Editing Research Genome 87

BioTech 365

DECEMBER 23, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Genetic engineering without unwanted side effects helps fight parasites.Modified CRISPR-Cas9 gene editing scissors are enabling researchers at the University of Zurich to make alterations to the genetic … Continue reading (..)

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Genetic Engineering Engineer Genetics Gene Editing 40

XTalks

JANUARY 26, 2024

Technological advancements are revolutionizing cancer research and therapies. Innovations in Cancer Therapy CRISPR/Cas9, a groundbreaking gene-editing technology, has demonstrated significant potential in oncology, offering new avenues for cancer treatment.

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Research Gene Editing Gene Genetics 118

Drug Discovery World

MAY 5, 2023

Eterna Therapeutics, a life science company focused on mRNA cell engineering, has acquired Exacis Biotherapeutics’ immuno-oncology platform. In contrast to DNA-based reprogramming and gene editing, the mRNA-based approach does not expose cells to expensive and potentially harmful viruses or DNA vectors.

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Gene Editing Engineer DNA Life Science 52

Drug Discovery World

JANUARY 9, 2023

In this early research, Khalid Shah, Professor of Neurosurgery at Harvard Medical School and Brigham and Women’s Hospital, and colleagues tested the vaccine in an advanced mouse model of brain cancer glioblastoma, with promising results. “Our CRISPR-Cas9 gene editing .

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Scientist Gene Editing Gene Engineer 52

Drug Discovery World

OCTOBER 10, 2023

The National Institutes of Health has awarded the first phase of a roughly $40m grant to Yale University to advance a novel CRISPR-based gene-editing delivery platform for the targeted treatment of neurogenetic diseases. The two diseases being targeted in the project are Angelman syndrome and H1-4 (HIST1H1E) syndrome. It’s astonishing.”

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Gene Editing Development Drugs Clinical Trials 52

Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. In the UK, according to Cancer Research UK, around 167,000 people die from cancer in the UK each year. Research into new drugs and therapeutics is on-going and is helping drive mortality rates down.

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Development Research Drugs Antibody 64

Drug Discovery World

MARCH 22, 2023

A new approach that delivers a ‘one-two punch’ to help T cells attack solid tumours is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania. By building on previous research, we are starting to get closer to strategies that seem to be promising in the solid tumour context.”

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Gene Editing Gene Engineer Regulation 52

WCG Clinical

NOVEMBER 17, 2023

Originally released in 1976, the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules ( NIH Guidelines ) serve as the foundation of biosafety-focused oversight of research involving recombinant or synthetic nucleic acids (rsNA). Since then, however, certain genetic engineering technologies (e.g.,

Genome 52

Genome Genomics Gene Editing Genetic Engineering 52

Drug Discovery World

DECEMBER 8, 2023

ONK Therapeutics and NAYA Biosciences have agreed to develop a combination therapy of ONK’s optimally-engineered natural killer (NK) cell therapies and NAYA’s FLEX-NK bispecific antibodies. ONK and NAYA plan to assess several combination therapies in preclinical cancer models in 2024 prior to subsequently exploring initiating clinical trials.

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Antibody Gene Editing Clinical Trials Clinical Trials 52

pharmaphorum

MAY 7, 2021

Gene editing firm CRISPR Therapeutics has announced a collaboration with US biotech Nkarta to develop natural killer (NK) cell therapies for cancer. It’s at the forefront of gene editing although the technology has spawned rivals including Intellia Therapeutics, Caribou Biosciences, Sangamo Therapeutics and Mammoth Biosciences.

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Gene Editing Gene Genetic Engineering DNA 52

Drug Discovery World

JUNE 7, 2023

The disease-relevant mutation is engineered into bit.bio’s human ioWild Type  cells using CRISPR/Cas9 gene editing. iPSC-derived cells from patients offer a human model for disease research but sourcing them with the disease-specific mutation of interest can be a complex and time-consuming process.

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Gene Editing Scientist Gene Engineer 52

Drug Discovery World

JUNE 30, 2023

The patent granted by EPO specifically covers CISH KO NK cells, and cancer therapies that utilise NK cells with CISH KO, as well as NK cells engineered with the foundational CISH KO in combination with IL-15 (soluble or engineered), TGFβR2 KO, or TGFβR2 KO and IL-15 (soluble or engineered).

Gene Editing 52

Gene Editing Engineer Licensing Licensing 52

BioTech 365

APRIL 9, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing … Continue (..)

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Gene Expression DNA Gene Editing Gene 40

Drug Discovery World

NOVEMBER 27, 2023

Upstream cell line development has seen notable progress with recent advances in cell line engineering, particularly in enhancing gene of interest integration specificity, clone selection, and production efficiency. Next-generation engineering tools, such as gene editing have enabled knock-out cell lines with enhanced characteristics.

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Production Engineer Gene Editing Gene 59

Drug Discovery World

NOVEMBER 24, 2023

 Traditional approaches to research won’t cut it The pursuit of scientific knowledge is not merely an academic endeavour, but a necessary pathway to improving the longevity and quality of human lives. But ultimately, for medicines to be rolled out worldwide, they need to work with not against the market.

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Research Life Science Gene Editing Vaccination 59

Scienmag

FEBRUARY 23, 2021

CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes; to watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to me Credit: Image courtesy of Julene Madariaga Marcos.

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DNA Gene Gene Editing Scientist 56

Drug Discovery World

DECEMBER 12, 2022

Meanwhile, a UAE researcher was selected as a finalist for AstraZeneca’s R&D Postdoctoral Challenge, reported the Khaleej Times 2. It then revealed its decision to fund the finalists from the challenge with research positions at one of its global R&D centres. Research news .

Drugs 52

Drugs Gene Editing Genome Genomics 52

Pharmaceutical Technology

JANUARY 10, 2023

Asklepios BioPharmaceutical has entered a research partnership and option agreement with ReCode Therapeutics for exploring its single-vector gene-editing platform. The new solution will enable complete gene insertion by delivering the gene-editing tool and DNA as mixed cargo to desired targets in one LNP.

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Gene Editing Gene Gene Therapy Genetics 130

Drug Discovery World

JULY 3, 2023

In the Modulating Tumour Microenvironment programme, experts took a deeper look at the results we are seeing from emerging immunotherapies such as immune checkpoint blockade and chimeric antigen receptor T cells (CAR Ts), and also discussed advances in our understanding of and strategies to modulate the tumour microenvironment.

Antibody 52

Antibody In-Vitro Engineer In-Vivo 52

Scienmag

JULY 2, 2021

The ongoing effort to explore […].

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Gene Silencing Gene Editing Gene DNA 75

Drug Discovery World

SEPTEMBER 6, 2022

Cell and gene therapies are not only transforming the way diseases are treated but are also aiming to cure entirely new patient populations. New applications and indications are being researched daily with the hope to address a wide array of rare and chronic diseases that have long been thought incurable.

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Gene Therapy Gene Gene Editing Manufacturing 52

Drug Discovery World

JANUARY 12, 2023

CRISPR allows researchers to target and edit specific genes in order to better understand the genome, human diseases and the effects of specific mutations. Scientists use complex gene editing and disease modeling systems to gain insights on the potential of CRISPR. .

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Gene Editing Gene Drugs In-Vivo 98

The Pharma Data

JANUARY 24, 2021

Bond joins Notch from Kite, where he most recently served as Vice President of Cellular Engineering. “Adding Chris to our leadership team will bolster our preclinical pipeline and translational research capabilities to accelerate development of the company’s cell therapy candidates from discovery into clinical application.”

Engineer 52

Engineer Gene Editing Genome Genomics 52

XTalks

MARCH 28, 2024

In recent years, the initiative has garnered considerable attention and helped increase education and research funding and provide better treatment options to fight this disease. There is also on-going research that aims to identify the most effective combinations and sequences of these therapies.

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Gene Editing Life Science Clinical Trials Clinical Trials 59

Bioengineer

JULY 23, 2021

Credit: Texas A&M Engineering. In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body. The team has recently submitted a patent disclosure with the Texas A&M Engineering Experiment Station.

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Engineer Gene Editing Clinical Trials Clinical Trials 52

Delveinsight

AUGUST 27, 2020

At Northwestern University, the researchers combined chemotherapy with an investigational bromodomain (BET) inhibitor to target breast cancer that had spread to the brain in mouse models. That overexpression of TUBB3 improved chemotherapy’s ability to target and kill the cancer cells in the brain, also reported by the researchers.

Vaccination 53

Vaccination Vaccine Research Trials 53

Drug Discovery World

DECEMBER 20, 2022

According to a survey of 150 biotech and biopharma leaders by clinical research company PPD , leveraging new technologies (including mRNA and drug discovery platforms) is one of the greatest opportunity areas in clinical trials for 2023. . Novel therapeutic platforms will drive innovation .

Drugs 52

Drugs Gene Editing Clinical Trials Clinical Trials 52

The Pharma Data

SEPTEMBER 1, 2021

With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation. million adults in the United States.

Drugs 52

Drugs Engineer Drug Delivery Gene 52

Bioengineer

JULY 19, 2021

WINSTON-SALEM, NC, JULY 19, 2021 — Wake Forest researchers and clinicians are using patient-specific tumor ‘organoid’ models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people. Credit: WFIRM. ” ###.

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Engineer Medicine Clinical Trials Clinical Trials 52

Drug Discovery World

JULY 10, 2023

This paid-for advertorial by Taconic appeared in DDW Volume 24 – Issue 3, Summer 2023 Overcoming challenges in model generation Genetically engineered mouse models are essential tools for biomedical research. In response, researchers often breed several founders.

Genetics 52

Genetics Gene Editing Genetic Engineering In-Vitro 52

Cloudbyz

MARCH 6, 2024

Pharmaceutical companies are increasingly investing in biotechnology research and development to capitalize on the growing demand for biologic therapies. Biologic drugs often command premium prices compared to their small molecule counterparts, reflecting the substantial investment required for research, development, and manufacturing.

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Gene Immune Response Manufacturing Gene Therapy 73

Drug Discovery World

DECEMBER 15, 2022

As gene editing technologies like CRISPR progress toward clinical study, researchers must continue to advance new approaches and address inherent challenges, explains Jon Chesnut, PhD, Senior Director, Cell Biology R&D, Thermo Fisher Scientific. Early phase clinical trials for gene editing therapies.

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Gene Editing Gene In-Vivo Genome 52