Drug Discovery World

AUGUST 31, 2023

Other potential cancer indications with ongoing in vitro work include breast and ovarian cancer. HBCI’s CEO, Dr Bomi Framroze said: “HBCI is at the forefront of research in using peptides to modulate gene expression. Our first therapeutic target is resistant castration-resistant prostate cancer (CRPC).

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Gene Expression Gene In-Vitro Research 52

Scienmag

DECEMBER 10, 2020

For this, they successfully generated reconstituted chromatin bearing histone modifications in vitro. Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model.

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Gene Expression In-Vitro Gene Scientist 52

Pharmaceutical Technology

AUGUST 11, 2022

Alnylam Pharmaceuticals and collaborators have identified rare mutations in the INHBE gene that is expressed in the liver, related to a lower waist-to-hip ratio for body mass index (BMI), which is often used as an indicator of abdominal fat and is correlated with the risk of type 2 diabetes (T2D) and coronary heart disease.

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Gene Biobanking Gene Expression In-Vitro 130

Drug Discovery World

AUGUST 22, 2023

In addition, total blood levels of sulforaphane (SFN) and SFN-metabolites were confirmed in the micromolar range, where efficacy is seen in vitro. Evgen Pharma has revealed the final data from its Phase Ib healthy volunteer study using the company’s new enteric coated tablet formation of its lead asset SFX-01.

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Gene Expression In-Vitro Gene Trials 52

Roots Analysis

JANUARY 14, 2024

Expression Systems for Biologics The processes associated with the manufacturing of biopharmaceuticals are complex and require highly sterile and aseptic conditions. It is worth mentioning that in vitro gene expression requires a suitable host for the production of a specific gene product.

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Contract Manufacturing Manufacturing Protein Bacteria 40

Drug Discovery World

AUGUST 3, 2022

Plus, in numerous in vitro experiments, the conjugate has been able to specifically enter ? CDMO in peptides and oligonucleotides manufacturing, Bachem, has started building a new future for oligonucleotides: solving the industry’s main challenges around capacity, sustainability and cost-effectiveness. Nanoparticles 6.

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Bioavailability In-Vivo RNA In-Vitro 52

Delveinsight

JANUARY 18, 2021

Usually, only a single copy of the gene is required that too from the mother, however, in cases of AS, either the child does not get any copy, or the child receives two copies – each from mother and father. Angelman syndrome (AS) is a complex genetic rare disorder that affects the nervous system.

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Marketing Gene Drugs Protein 52