Scienmag

OCTOBER 1, 2020

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. . — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.

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Scienmag

MARCH 9, 2021

CHOP researchers find small changes in RNA due to RNA editing could have a large impact on gene expression and phenotype Philadelphia, March 9, 2021–Combining computational mining of big data with experimental testing in the lab, researchers at Children’s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence (..)

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Scienmag

JULY 12, 2021

Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […]. The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell.

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Drug Discovery Today

APRIL 24, 2023

Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that variations in chromatin accessibility, and thus gene expression, may explain why people of European descent with APOE4 gene variants have a greater risk of developing Alzheimer’s disease than people of African descent with similar genetics.

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Medical Xpress

FEBRUARY 10, 2023

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

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Medical Xpress

MARCH 13, 2023

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

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BioTech 365

NOVEMBER 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study highlights role of disordered protein interactions in gene expression.A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered … Continue reading →

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Medical Xpress

NOVEMBER 22, 2022

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

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Drug Discovery World

FEBRUARY 27, 2024

CAR-T Therapies have revolutionised the field of personalised medicine, especially in oncology. Orchestrating the naturally occurring conductors of gene expression can shift the functional state of cells and alter gene expression. BS: The field of genetic tuning is full of innovation and potential.

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Scienmag

MARCH 19, 2021

Credit: Thomas Gorochowski In a recent study led by the University of Bristol, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.

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Scienmag

MAY 16, 2022

Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment.

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Scienmag

DECEMBER 22, 2020

Blocking gene expression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read.

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Drug Discovery World

FEBRUARY 16, 2024

Small RNAs promote wound-healing without scarring A class of molecules playing a crucial role in the regulation of gene expression and other cellular processes can restore normal skin structure rather than producing a scar, a University of Manchester-led study suggests.

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Scienmag

SEPTEMBER 29, 2020

By changing gene expression first, some immunotherapies may work better, models show Credit: (courtesy of Hackensack Meridian Health) September 29, 2020 – Nutley, NJ – A one-two punch of changing gene expression, then deploying immune checkpoint inhibitors, shows promise in battling one of the most treatment-resistant types of cancer in (..)

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Scienmag

SEPTEMBER 10, 2020

Findings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […]. (..)

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Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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Scienmag

APRIL 5, 2021

Study shows that tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression PHILADELPHIA – A team led by scientists at the Perelman School of Medicine at the University of Pennsylvania has illuminated the functions of mysterious structures in cells called “nuclear speckles,” showing that they can work in (..)

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Drug Discovery World

FEBRUARY 14, 2024

A class of molecules playing a crucial role in the regulation of gene expression and other cellular processes can restore normal skin structure rather than producing a scar, a University of Manchester-led study suggests. The findings offer hope for a solution to the global problem of non-healing wounds, thought to cost between £11.25

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Scienmag

JUNE 9, 2021

First study to show gene expression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. However, we still know relatively little about its physiological basis.

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Drug Discovery World

JULY 27, 2023

The researchers from Boston University Chobanian & Avedisian School of Medicine in collaboration with the Icahn School of Medicine, Columbia University and the New York State Psychiatric Institute used experimental models to explore the cellular actions of tianeptine.

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XTalks

AUGUST 5, 2020

Visium Spatial Gene Expression Solution. To address challenges associated with loss of spatial context, 10x Genomics has developed the Visium Spatial Gene Expression solution, which enables answering biological questions in the context of tissue using an unbiased gene expression approach.

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Scienmag

FEBRUARY 18, 2021

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

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Scienmag

MAY 14, 2021

The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including […].

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Drug Discovery World

SEPTEMBER 27, 2023

Founder Dr Moshe Szyf Founder shares the potential of harnessing precision medicine. Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy.

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Scienmag

FEBRUARY 23, 2021

Credit: Sorbonne Université Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage (..)

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Scienmag

NOVEMBER 9, 2020

million National Institute on Aging grant to USC’s Eileen Crimmins supports collaboration of large studies in US, Republic of Ireland and Northern Ireland to answer questions about how life circumstances affect gene expression and health.

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Scienmag

SEPTEMBER 28, 2020

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of (..)

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Scienmag

AUGUST 4, 2020

Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing […].

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Scienmag

MARCH 3, 2021

Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an ‘aging clock’ that reads the biological age of an organism directly from its gene expression, the transcriptome.

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Scienmag

DECEMBER 24, 2020

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche Credit: ©Atsushi IWAMA, The Institute of Medical Science, The University of Tokyo By transferring mouse aged hematopoietic stem cells (aged HSCs, *1) to the environment of young mice (bone marrow niche, *2), it was demonstrated that the pattern of stem cell gene expression (..)

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Pharma Marketing Network

DECEMBER 21, 2020

Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e., those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies.

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Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

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The Pharma Data

FEBRUARY 24, 2022

UNC researchers now show that these two factors can directly associate with one another, modulating cancer-cell-specific programs of gene expression. ” They found that EZH2 possesses two different binding patterns on chromatin in acute leukemia cells, eliciting two distinct gene-regulatory programs (Figure 1).

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Scienmag

JUNE 14, 2021

The study, “Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure,” is published in the journal Translational Psychiatry by researchers […].

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Scienmag

MAY 23, 2021

Press release – Abstract 1394: Alterations in clock genes expression in Eutopic and Ectopic Endometrial Tissue New research suggests that night shift work is linked to menstrual irregularity and increased chance of developing endometriosis According to a study being presented at the 23rd European Congress of Endocrinology (e-ECE 2021), on Sunday (..)

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Scienmag

JANUARY 11, 2021

These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a […].

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The Pharma Data

JULY 12, 2021

online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval. “Academic labs and pharmaceutical and? the success rates in drug discovery?are

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