Medical Xpress

FEBRUARY 21, 2023

A large research project, led by scientists at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, has found that whole genome sequencing (WGS) can provide much more information about classic Hodgkin lymphoma (cHL) than exome sequencing, (..)

Genome 72

Genome Genomics Research Protein 72

pharmaphorum

AUGUST 4, 2022

Unlocking the secrets of the human genome has long been an ambitious pursuit for researchers around the world. Today, the landscape of genomic testing and research is rapidly progressing, with significant scientific and technological advances driving a paradigm shift in the understanding of oncology at a molecular level.

Genome 52

Genome Genomics Genome Project DNA 52

Scienmag

FEBRUARY 12, 2021

— An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells. Research offers new lead for cancer drug discovery Credit: Rensselaer Polytechnic Institute TROY, N.Y.

Genome 98

Genome Genomics DNA Protein 98

Scienmag

APRIL 15, 2021

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos Credit: MPI of Immunobiology and Epigenetics, F. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This […].

Genome 56

Genome Genomics DNA Genetics 56

Scienmag

DECEMBER 22, 2021

Genes code for proteins – the building blocks of life. of our entire DNA Very little is known about the function of regions of DNA outside our genes – termed the ‘dark genome’ A Cambridge-led team recently discovered that proteins are produced by over […].

Genome 63

Genome Genomics DNA Gene 63

pharmaphorum

AUGUST 5, 2021

Protein-protein interactions (PPIs) are becoming increasingly relevant in the pathology of many diseases, including cancer. PPIs are an integral part of the physiology of living organisms, as complexes which control biological pathways mediated by proteins. These regions are critical for optimal interactions between proteins.

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Protein Gene Bioassay DNA 126

Pharmaceutical Technology

MAY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Oncolytic viral proteins. Sillajen and Advaxis are the other key patent filers of oncolytic viral proteins.

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Protein Gene Genetics Gene Therapy 130

Medical Xpress

APRIL 17, 2023

Columbia researchers have shined new light on how the "dark" part of the genome allows cancer cells to be detected by the immune system, which could lead to better immunotherapies.

Protein 75

Protein Genome Genomics Research 75

Scienmag

NOVEMBER 20, 2021

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

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DNA Gene Expression Genome Genomics 96

Scienmag

FEBRUARY 21, 2021

‘Exploring one of the biggest challenges facing genomics today – understanding genetic variants’ SEATTLE (February 22, 2021) – Global experts performing leading edge research in precision medicine, functional genomics, protein science, and variant interpretation and prediction will share their expertise and insights April 5-7 (..)

Genome 40

Genome Genomics Genetics Protein 40

Scienmag

MAY 11, 2021

MIT researchers have determined the virus’ protein-coding gene set and analyzed new mutations’ likelihood of helping the virus adapt. CAMBRIDGE, MA — In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2.

Genome 40

Genome Genomics Gene Protein 40

Scienmag

MARCH 12, 2021

Credit: The Wistar Institute PHILADELPHIA — (March 12, 2021) — Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome […].

RNA 92

RNA Protein Genome Genomics 92

BioTech 365

OCTOBER 26, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: A ‘genomic rosetta stone’ for discovering the rules of gene regulation.As

Genome 40

Genome Genomics Gene Regulation 40

BioTech 365

DECEMBER 1, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Genomics, gene-editing and the Blue Revolution.Aquaculture—the farming of fish and shellfish, is the world’s fastest growing primary industry.

Gene Editing 40

Gene Editing Genome Genomics Gene 40

BioTech 365

OCTOBER 11, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Machine learning offers high-definition glimpse of how genomes organize in single cells.Within the microscopic boundaries of a single human cell, the intricate folds and arrangements of protein … Continue reading → (..)

Genome 40

Genome Genomics Protein Research 40

Scienmag

JUNE 28, 2021

Small molecule designed to inhibit protein aggregation associated with Alzheimer’s disease and Type II diabetes is shown to effectively reactivate a critical tumor suppressor protein inactivated in more than one-half of all human cancers Fast facts 1) Dubbed the ‘guardian of the genome’, p53 is a tumor suppressor protein that prevents (..)

Protein 72

Protein Genome Genomics Development 72

Scienmag

MARCH 9, 2022

— Each simple RNA virus has a genome, its “native RNA.” This genome dictates how the virus replicates in cells to eventually cause disease. The genome also has the code for making a capsid, the protein shell of a virus that encapsulates the genome and protects it like a nanocontainer. RIVERSIDE, Calif.

Packaging 84

Packaging Packaging Genetics Genome 84

Scienmag

SEPTEMBER 16, 2020

Credit: Matt Jaremko/CSHL Joshua-Tor lab The most basic activity of a living thing is to turn one copy of its genome into two copies, crafting one cell into two. That replication event begins with a set of proteins–the Origin of Replication Complex (ORC).

Genome 42

Genome Genomics Protein Gene 42

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. PRC2 can be blocked with chemicals, but they are imprecise, affecting PRC2 function throughout the genome. it can be reawakened.

Protein 52

Protein Gene Genome Genomics 52

Scienmag

AUGUST 11, 2020

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

Bacteria 41

Bacteria Genome Genomics Protein 41

Scienmag

OCTOBER 21, 2020

Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, […].

Protein 76

Protein Genome Genomics Research 76

BioTech 365

JUNE 4, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: The cut and restore protein trick: Self-excising designer proteins.Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, … Continue reading →

Protein 40

Protein Genome Genomics Gene 40

Medical Xpress

MAY 4, 2023

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it. While the gene was discovered more than four decades ago, researchers have so far been unsuccessful at determining exactly how it works.

Scientist 105

Scientist Gene Genome Genomics 105

Pharmaceutical Technology

JUNE 23, 2022

It functions as a molecular scissor by slicing long chains of virus’ polypeptide proteins into smaller component proteins. These viruses can develop rapid defences at the cellular level by orchestrating these layers, or folding mechanisms, in viral proteins so the key is to find a way to shut them down.”.

Drugs 130

Drugs Protein Genome Genomics 130

Drug Discovery World

OCTOBER 2, 2023

X-Chem and the Structural Genomics Consortium (SGC) have entered a collaboration aimed at creating new chemical tools to study human proteins. Under the agreement, X-Chem will use its DEL platform to create datasets for proteins chosen and supplied by the SGC, which will be posted to a public portal to be used for model building.

Genome 52

Genome Genomics Protein DNA 52

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry CRISPR nuclease is a key innovation area in pharmaceutical development CRISPR, which refers to clustered regularly interspaced short palindromic repeats, are bacteriophage-derived DNA sequences that had previously infected the prokaryote and are found in the genomes of bacteria and archaea.

In-Vivo 162

In-Vivo Genome Genomics Gene Editing 162

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1. To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase.

Protein 52

Protein Genome Genomics Research 52

pharmaphorum

FEBRUARY 25, 2022

A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Indeed, this latest discovery follows scientists uncovering the genome stage of development in mouse embryonic stem cells (ESCs) a decade ago.

Research 68

Research Genome Genomics Protein 68

Scienmag

OCTOBER 13, 2020

The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). A research team from Cologne has discovered that a change in the DNA structure – more precisely in the chromatin – plays a decisive role in the recovery phase after DNA damage. The discovery was made by […].

Genome 72

Genome Genomics DNA Research 72

Bioengineer

JANUARY 16, 2024

This mutation hinders the drug’s binding to the mutant EGFR protein. Osimertinib, however, can covalently bind to the T790M and cysteine-797 (C797) residue at the protein’s ATP binding site, overcoming resistance mechanisms. T790M loss has been linked to earlier resistance and poorer survival in other cohorts.

Genome 119

Genome Genomics Protein In-Vitro 119

pharmaphorum

MAY 12, 2022

Bristol-Myers Squibb’s Celgene unit has clearly been impressed by progress in its four-year-old alliance with Evotec on protein degradation. These small drug compounds destabilise proteins by bringing them into proximity with enzymes called E3 ubiquitin ligases that cause them to be broken down. billion partnership last week. .

Protein 52

Protein Genome Genomics Drugs 52

Scienmag

NOVEMBER 20, 2020

It contains the information for the production of 27 proteins. This is not much compared to the possible 40,000 kinds of protein that a […].

Genome 70

Genome Genomics RNA Protein 70

Medical Xpress

JANUARY 20, 2023

In their paper published in the journal Science, the group describes using the gene editing system to modify two bases in the mouse genome to prevent hyperactivation of a protein that can lead to heart disease.

Gene Editing 81

Gene Editing Genome Genomics Gene 81

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

Genetics 105

Genetics DNA Genome Genomics 105

Drug Discovery World

FEBRUARY 22, 2024

The astonishing pace of innovation has led to new, potentially safer CRISPR-based techniques, including base editing, prime editing and epigenome editing, and researchers are moving beyond the Cas9 system to Cas12 and other proteins, opening the realms of possibilities for genomic editing.

Gene Editing 52

Gene Editing Gene Genome Genomics 52

Drug Discovery World

JANUARY 26, 2023

This is the latest episode of the free narrated DDW podcast, “CRO’s and targeted protein degradation offer an exciting future”. They are called “ CROs: Drug discovery expertise on hand ” and “ Why the emergence of targeted protein degradation is so exciting ”.

Protein 52

Protein Drugs Research Marketing 52

STAT News

APRIL 10, 2023

So we were excited when we were referred to a pediatric geneticist who offered Gabrielle whole exome sequencing , which sequences all of the protein-coding regions of the genome, to determine whether there was a genetic cause. Read the rest…

Genetics 98

Genetics Genome Genomics Protein 98