Scienmag

MAY 11, 2021

MIT researchers have determined the virus’ protein-coding gene set and analyzed new mutations’ likelihood of helping the virus adapt. CAMBRIDGE, MA — In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2.

Genome 40

Genome Genomics Gene Protein 40

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Now scientists at La Jolla Institute for Immunology (LJI) and Scripps Research have found a promising strategy for stopping Ebola virus polymerase. For the new study, Fang and her colleagues tried a new strategy.

Protein 52

Protein Genome Genomics Research 52

Drug Discovery World

NOVEMBER 22, 2022

The new strategy aims to implement new approaches to target cancer – by setting up streamlined processes to prioritise potential drug targets and employing state-of-the-art technology to eradicate cancer proteins from cells. . Opening up new lines of attack.

Scientist 52

Scientist Immune Response Research Drugs 52

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

Genetics 105

Genetics DNA Genome Genomics 105

Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

Genome 70

Genome Genomics RNA Protein 70

Scienmag

NOVEMBER 20, 2020

20, 2020) — For more than a decade, scientists studying epigenetics have used a powerful method called ChIP-seq to map changes in proteins and other critical regulatory factors across the genome. Credit: Courtesy of Van Andel Institute GRAND RAPIDS, Mich.

Genome 91

Genome Genomics Protein Scientist 91

pharmaphorum

FEBRUARY 25, 2022

A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Indeed, this latest discovery follows scientists uncovering the genome stage of development in mouse embryonic stem cells (ESCs) a decade ago.

Research 67

Research Genome Genomics Protein 67

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

Protein 130

Protein RNA Genome Genomics 130

Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

Drugs 52

Drugs Gene Editing Genome Genomics 52

The Pharma Data

FEBRUARY 24, 2022

On the one hand, EZH2 forms a canonical protein complex termed PRC2, leading to gene repression at a set of genomic regions; on the other hand, EZH2 interacts with cMyc to activate gene expression at genomic sites distinctive from the above ones.

Scientist 52

Scientist Gene Expression Gene Genome 52

Drug Discovery World

OCTOBER 26, 2023

The technologies cover the whole range of biomolecules from genes to protein to metabolites. While we are using standard commercially available processes for genomics, we have invested massively into high-throughput and high-resolution transcriptomics, proteomics, and metabolomics methods. phosphorylations or ubiquitinations).

Drugs 52

Drugs Protein Genome Genomics 52

XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. The researchers focused on the spike proteins that protrude from the surface of the coronavirus, which are responsible for viral attachment and entry into host cells.

RNA 98

RNA Protein Genome Genomics 98

Drug Discovery World

NOVEMBER 1, 2022

Researchers say they have successfully used a cell’s natural process for making proteins to ‘slide’ genetic instructions into a cell and produce critical proteins missing from those cells. . Two methods currently used to deliver protein-making packages into cells, ‘mini promoters’ and serotype-mediated gene expression, vary widely.

Gene Expression 52

Gene Expression Gene Packaging Packaging 52

Drug Discovery World

APRIL 19, 2023

Scientists at The Institute of Cancer Research, London, are teaming up with small molecule neoantigen immuno-oncology company NeoPhore to develop new potential cancer drugs. Under a new strategic research collaboration, an ICR team led by Professor Chris Lord will investigate the effect of NeoPhore’s inhibitors on tumours in the laboratory.

DNA 98

DNA Development Drugs Genome 98

Scienmag

APRIL 16, 2021

Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome — proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

DNA 40

DNA Genome Genomics Gene 40

Drug Discovery World

MARCH 2, 2023

Epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome. But the new findings answer a fundamental and longstanding question – how epigenetic proteins regulate the processes of transcription and gene expression, through which our genes are read and translated into proteins.

Gene Expression 52

Gene Expression Gene DNA RNA 52

The Pharma Data

MARCH 31, 2023

Better understanding of enzymes and their functions would be a boon for research in genomics, chemistry, industrial materials, medicine, pharmaceuticals and more. “Almost every researcher, when working with a new protein sequence, wants to know right away what the protein does. .

Protein 40

Protein Genome Genomics Engineer 40

Drug Discovery World

APRIL 8, 2024

Aviv Regev, Head and Executive Vice President of Research and Early Development at Genentech, opened the session with a discussion of how advances in genomic sequencing are fostering the development of data-rich cell atlases and what that data could mean for new insights into cancer biology and novel therapeutics.

In-Vivo 52

In-Vivo In-Vitro Antibody Protein 52

Drug Discovery World

MAY 25, 2023

Gyros Protein Technologies: Gyrolab Generic Cyno Anti-Drug Antibodies (ADA) Kit Reagents The kit reagents are for the detection of circulating immune complexes of human IgG with cyno anti-human IgG.

Production 52

Production Reagent DNA Drugs 52

The Pharma Data

DECEMBER 17, 2020

Lupus causes the production of proteins called autoantibodies in the immune system, which attack tissues and organs, including the kidneys. Klisyri is a home-grown product discovered and characterized by Athenex scientists and developed from pre-IND to NDA by the Athenex team. We are extremely proud of our team’s excellent execution.

FDA Approval 52

FDA Approval Genome Genomics Production 52

Drug Discovery World

NOVEMBER 8, 2022

“By doing a temporal analysis, we were able to see how the virus has evolved over time, and a key finding was the virus is now accumulating mutations specifically where drugs and antibodies from vaccines are supposed to bind,” said Shrikesh Sachdev, Senior Research Scientist. .

Drugs 52

Drugs DNA Vaccination Vaccine 52

Drug Discovery World

SEPTEMBER 1, 2023

In the new study, led by scientists at The Institute of Cancer Research and published in Nature Communications , researchers identify a new cellular role of a protein called EXD2 nuclease and, importantly, its role in the so-called ALT (alternative lengthening of telomeres) pathway.

Drugs 59

Drugs Protein Research DNA 59

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

Genome 101

Genome Genomics Genetics Genome Project 101

XTalks

JULY 14, 2022

For example, when T cells (a type of white blood cells that fight off infections and cancer) are activated in our immune systems, thousands of proteins in these cells change. The proteins are interconnected and changes in one protein level can impact that of another.

Gene 98

Gene Regulation Protein Gene Editing 98

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g. Dr. Connor W.

Protein 52

Protein Scientist Gene Development 52

XTalks

MARCH 18, 2024

By genetically editing microorganisms, scientists can now manipulate the metabolic pathways to produce foods with desirable properties. It allows for the production of animal-free dairy proteins, such as casein and whey, which are identical to their cow-produced counterparts.

Genetic Engineering 52

Genetic Engineering Genetics Production Protein 52

pharmaphorum

FEBRUARY 1, 2022

2 is now the dominant strain of the COVID-19 virus in Denmark, and scientists from the country’s Statens Serum Institute (SSI) have compared the two subvariants in more than 8,500 households including almost 18,000 people. The new BA.2 2 subvariant of Omicron is around 50% more transmissible than the original BA.1

Vaccination 98

Vaccination Vaccine Scientist Genome 98

pharmaphorum

SEPTEMBER 9, 2020

Geneticist Dr Charles Steward has spent his career studying the human genome – but his work became much more personal when his children were diagnosed with severe neurological diseases. Charlie told pharmaphorum how his search for a genetic cause has led him to straddle the divide between scientist and patient advocate.

Genome 79

Genome Genomics Genetics Genome Project 79

Drug Discovery World

APRIL 17, 2024

JMB: Regulatory RNAs (or regRNAS) are molecules that directly control the expression of nearby protein-coding genes. So, regRNAs haven’t been exploited previously because scientists have only recently understood their role in regulating gene expression. What is regRNA and why hasn’t it been exploited as a therapeutic target before?

Gene Expression 59

Gene Expression Gene Genetic Disease RNA 59

The Pharma Data

JUNE 19, 2022

A new study led by Penn State College of Medicine scientists finds that another type of immune cell – natural killer cells – can be harnessed to pick up the slack when T cells no longer work and may also reinvigorate T cells to attack melanoma tumors.

Drugs 52

Drugs Protein Immune Response Dermatology 52

Drug Discovery World

MARCH 7, 2023

Indeed, QCRI is currently working with other organisations in Qatar including Qatar Biobank, to further research and develop data sets that contain whole genome sequences. “Current work at QCRI focuses on developing polygenic risk scores for complex diseases and traits using local Qatari data.

Biobanking 52

Biobanking Drugs Genome Genomics 52

The Pharma Data

FEBRUARY 25, 2022

Several FDA-approved drugs – including for type 2 diabetes, hepatitis C and HIV – significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. ” The findings published today (Feb. 25) in the journal Communications Biology.

FDA Approval 52

FDA Approval Drugs Protein In-Vitro 52

Drug Discovery World

APRIL 6, 2023

The workshop will be led by hfp consulting, a firm which specialises in career development and leadership training for scientists. This session will take place during the meeting on Saturday, 15 April, 2023 at 11:45 PM – 3:45 PM EST. Location: Orange County Convention Center, Rooms W 340AB.

Protein 52

Protein Clinical Trials Clinical Trials Antibody 52

pharmaphorum

JANUARY 24, 2022

Some scientists have given it the nickname ‘stealth variant’, because it is more difficult to detect than BA.1 1 and doesn’t share the genetic deletion on the spike protein that has been used to monitor the spread of Omicron and distinguish it from Delta, which fuelled the last wave of COVID-19 cases. .

Vaccination 98

Vaccination Vaccine Genome Genomics 98

pharmaphorum

JANUARY 20, 2021

A genomic analysis of the SARS-CoV-2 coronavirus, which causes COVID-19, shows that the virus accumulates around two mutations a month. The new variant identified in the UK in December shows significant mutations in the Spike protein and receptor binding domain that increase its infectivity.

Vaccination 52

Vaccination Vaccine Protein RNA 52

Drug Discovery World

DECEMBER 12, 2022

According to the publication, “A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognise mutated proteins specific to a person’s tumours. In Nature 3 , we learnt about the CRISPR cancer trial success leading the way to personalised treatments. Analysis .

Drugs 52

Drugs Gene Editing Genome Genomics 52

Drug Discovery World

FEBRUARY 6, 2024

Sanofi has stated that it intends to become the first pharma company “powered by AI at scale”, and as part of this ambition, agreed a collaboration with BioMap to co-develop advanced AI models and protein Large Language Models that that it hopes will enable biologics design and multiparametric optimisation 2.

Marketing 69

Marketing Medicine Genome Genomics 69