XTalks

SEPTEMBER 15, 2020

Specifically, the vaccine contains human recombinant glutamate decarboxylase 65 (GAD65) protein conjugated to aluminum hydroxide (GAD-alum). The vaccine triggers an immune response against pro-inflammatory processes resulting from autoimmune attack of the pancreas – the inflammation helps to destroy the insulin-producing ?-islet

Vaccination 103

Vaccination Vaccine Insulin Trials 103

Drug Discovery World

SEPTEMBER 5, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Development 59

Development Drugs Protein Genotype 59

Drug Discovery World

AUGUST 25, 2023

However, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. Initial screening of treatments may utilise the highly proliferative Chinese Hamster Ovarian (CHO) or Human Embryonic Kidney (HEK) cell lines with the liver protein(s) of interest exogenously expressed.

Gene Therapy 52

Gene Therapy Gene Development Genotype 52

Drug Discovery World

SEPTEMBER 26, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Development 52

Development Drugs Protein Genotype 52

Drug Discovery World

SEPTEMBER 19, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Development Protein 52

The Pharma Data

MARCH 25, 2021

SG is a first-in-class therapy targeting Trop-2, a protein frequently expressed in multiple types of epithelial tumors, such as TNBC, where high expression is associated with poor survival and relapse. More information about ASCENT is available at [link]. About Sacituzumab Govitecan-Hziy.

Genotoxicity 52

Genotoxicity Genotype Containment Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modeling.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

FEBRUARY 9, 2024

Primary hepatocytes represent the gold standard in vitro cell model for functionality, however, when isolated from liver tissue, primary cells maintain expression of key proteins for only a short period. However, hepatoma lines may lack the key proteins essential for modelling.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

Drug Discovery World

MAY 2, 2023

These modifications lead to alterations in the function of the proteins expressed by these genes, manifesting in cellular processes dependent on those proteins. This indicates that an efficient anti-cancer therapy must inhibit the activity of the proteins expressed by these genes. CRISPR libraries: Why do we need them?

Genome 52

Genome Genomics Gene DNA 52

Drug Discovery World

DECEMBER 12, 2023

Greater than 95% of severe clinical cases are homozygous for the PiZ mutation (known as the PiZZ genotype). Korro has generated preclinical data demonstrating high editing efficiency (>50% editing), which it believes is a key threshold to achieving clinically meaningful secretion of normal A1AT protein in an in vivo mouse model, and targeted (..)

RNA 52

RNA In-Vivo Genotype Genetics 52

Drug Discovery World

OCTOBER 18, 2022

Enanta Pharmaceuticals, a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has dosed the first subject in its Phase I clinical trial of EDP-323, a novel, oral L-protein inhibitor in development for the treatment of respiratory syncytial virus (RSV). . Context .

In-Vitro 52

In-Vitro Genotype Bioavailability Clinical Trials 52

XTalks

DECEMBER 12, 2023

Efficacy: By comparing with baseline data, clinicians can discern changes in key imaging biomarkers, from the size of brain structures like grey matter, white matter and CSF, to the size of an infarct or the presence of specific proteins like tau or amyloid.

Trials 111

Trials Clinical Trials Clinical Trials Genetics 111

The Pharma Data

APRIL 7, 2021

Trodelvy is directed to the Trop-2 receptor, a protein frequently expressed in multiple types of epithelial tumors, including TNBC, where high expression is associated with poor survival and relapse. Trodelvy also extended median overall survival (OS) to 11.8 months vs. 6.9 months (HR: 0.51; 95% CI: 0.41-0.62; About Trodelvy.

HR 52

HR Genotype FDA Approval Genotoxicity 52

Roots Analysis

AUGUST 31, 2023

The nutrigenomic testing employs various techniques / tools to determine the effect of diet on genome; these tools have been described below: Tools for Nutrigenomics Testing Microarray Technologies: These types of technologies have enabled the study of physiological effect of different nutrition, such as proteins and other dietary components.

Genome 40

Genome Genomics Genetics Gene 40

The Pharma Data

JANUARY 26, 2021

Eli Lilly’s bamlanivimab targets different sites on the SARS-CoV-2 spike protein. VIR-3434 is an HBV-neutralizing monoclonal antibody designed to block entry of all 10 genotypes of HBV into hepatocytes and reduce the level of virions and subviral particles in the blood.

Antibody 52

Antibody Genotype Trials Nurses 52

The Pharma Data

APRIL 14, 2021

The incidence of Grade 3-4 neutropenia in genotyped patients was 67% in patients homozygous for the UGT1A1*28, 46% in patients heterozygous for the UGT1A1*28 allele and 46% in patients homozygous for the wild-type allele. More information on TROPiCS-04 is available at [link]. About Trodelvy.

Genotype 52

Genotype Containment FDA Approval Genotoxicity 52

Drug Discovery World

MARCH 1, 2023

A high-content imaging assay can be tailored to the biological questions under investigation, enabling in-depth characterisation of complex cellular phenotypes such as protein/RNA localisation, metabolic state, cell morphology, cell-cell interactions, and live-cell dynamics.

Genetics 52

Genetics Genome Genomics Genotype 52

Drug Discovery World

JULY 15, 2022

Nanopore sequencing relies on determination of the chemical composition of the nucleic acids by passing a single strand of nucleic acids through a protein nanopore 6. In contrast, the maximum read length of the next generation sequencing technology such as Illumina HiSeq 2500 is only 250 bps.

Genome 52

Genome Genomics DNA Containment 52

The Pharma Data

NOVEMBER 24, 2020

Management options to date were limited to hyperhydration, crystallization inhibitors and, in a minority of patients with a specific genotype, pyridoxine (vitamin B6). This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.

FDA Approval 52

FDA Approval Production RNA Medicine 52